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Cat. No.: HY-147338A

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5-Methylcytidine 5′-triphosphate trisodium

Name: 5-Methylcytidine 5′-triphosphate trisodium
Brand: MedChemExpress
SKU: HY-147338A
Price: 275.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 5-Methyl-CTP trisodium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium) is a modified cytidine triphosphate nucleotide. 5-Methylcytidine 5′-triphosphate trisodium serves as a modified nucleotide substrate for in vitro transcription, partially or completely replacing CTP. 5-Methylcytidine 5′-triphosphate trisodium enhances mRNA stability and translation efficiency, and reduces activation of the innate immune system. 5-Methylcytidine 5′-triphosphate trisodium is used in RNA synthesis-related research.

For research use only. We do not sell to patients.

Purity: 99.62%
Formula: C₁₀H₁₅N₃Na₃O₁₄P₃
Molecular Weight:563.13

Storage:

Solution, -20°C, 2 years

5-Methylcytidine 5′-triphosphate trisodium Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP) can participate in the synthesis of modified PTEN mRNA, substituting for standard cytidine triphosphate to produce modified mRNA with reduced immunostimulatory properties; PTEN mRNA can restore PTEN protein expression in PTEN-deficient PC3 prostate cancer cells^[1].
5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP) is successfully incorporated into in vitro transcribed mRNA to generate modified mRNA for downstream delivery applications^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Liquid
Molecular Weight 563.13
Formula C₁₀H₁₅N₃Na₃O₁₄P₃
Color Colorless to light yellow
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C(N=C(N)C(C)=C2)=O
Synonyms

5-Methyl-CTP trisodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Publications (1)

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Cell Rep

Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. [Abstract]

2023 May 23;42(6):112550. PMID: 37224018

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Islam MA, et al. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nature biomedical engineering. 2018 Nov;2(11):850-864.

[2]. Baba M, et al. Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. Journal of controlled release : official journal of the Controlled Release Society. 2015 Mar 10;201:41-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

5-Methylcytidine 5′-triphosphate trisodium

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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5-Methylcytidine 5′-triphosphate trisodium

Publications Citing Use of MedChemExpress (MCE) 5-Methylcytidine 5′-triphosphate trisodium

All DNA/RNA Synthesis Isoforms