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Results for "

glycinamide

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

2

Biochemical Assay Reagents

11

Peptides

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10820
    Pemetrexed
    Maximum Cited Publications
    39 Publications Verification

    LY231514

    		 Antifolate Autophagy Cancer
    Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed
  • HY-10820A
    Pemetrexed disodium
    Maximum Cited Publications
    39 Publications Verification

    LY231514 disodium

    		 Antifolate Autophagy Apoptosis Cancer
    Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed disodium
  • HY-14521
    Lometrexol
    3 Publications Verification

    DDATHF

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol
  • HY-13781
    Pemetrexed disodium hemipenta hydrate
    Maximum Cited Publications
    39 Publications Verification

    LY231514 disodium hemipenta hydrate

    		 Antifolate Autophagy Apoptosis Infection Neurological Disease Inflammation/Immunology Cancer
    Pemetrexed (LY231514) disodium hemipenta hydrate is a CNS-penetrant antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
    Pemetrexed disodium hemipenta hydrate
  • HY-P4070
    Insulin icodec

    		Insulin Receptor Metabolic Disease
    Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
    Insulin icodec
  • HY-10820B
    Pemetrexed disodium heptahydrate
    Maximum Cited Publications
    39 Publications Verification

    LY231514 disodium heptahydrate

    		 Antifolate Autophagy Cancer
    Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
    Pemetrexed disodium heptahydrate
  • HY-14530
    Pelitrexol
    2 Publications Verification

    AG 2037

    		 Antifolate Cancer
    Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice .
    Pelitrexol
  • HY-10820R
    Pemetrexed (Standard)

    LY231514 (Standard)

    		 Reference Standards Antifolate Autophagy Cancer
    Pemetrexed (Standard) is the analytical standard of Pemetrexed. This product is intended for research and analytical applications. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed (Standard)
  • HY-P1103
    CTCE-9908
    1 Publications Verification

    		 CXCR Cancer
    CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .
    CTCE-9908
  • HY-Y1123
    2-Aminoacetamide hydrochloride

    glycinamide hydrochloride

    		 Amino Acid Derivatives Phosphatase Endocrinology
    2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro and bone regeneration in vivo .
    2-Aminoacetamide hydrochloride
  • HY-10818
    LY309887

    		Antifolate Cancer
    LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.
    LY309887
  • HY-14521B
    Lometrexol hydrate
    3 Publications Verification

    DDATHF hydrate

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol hydrate
  • HY-14521A
    Lometrexol disodium
    3 Publications Verification

    DDATHF disodium

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol disodium
  • HY-P3216
    Oxytocin free acid

    9-Deamidooxytocin

    		 Oxytocin Receptor Endocrinology
    Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .
    Oxytocin free acid
  • HY-P3216B
    Oxytocin free acid TFA
    10+ Cited Publications

    9-Deamidooxytocin TFA

    		 Oxytocin Receptor Endocrinology
    Oxytocin free acid (9-Deamidooxytocin) TFA is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .
    Oxytocin free acid TFA
  • HY-W845607
    Milacemide

    		Monoamine Oxidase Neurological Disease
    Milacemide, a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide is promising for research of Alzheimer's disease .
    Milacemide
  • HY-W101495
    Boc-Leu-OH hydrate

    N-Boc-L-leucine monohydrate

    		 Amino Acid Derivatives Others
    Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
    Boc-Leu-OH hydrate
  • HY-10819
    AG2034

    		Antifolate Cancer
    AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folate receptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED .
    AG2034
  • HY-10820BR
    Pemetrexed disodium heptahydrate (Standard)

    LY231514 disodium heptahydrate (Standard)

    		 Reference Standards Antifolate Autophagy Cancer
    Pemetrexed (disodium heptahydrate) (Standard) is the analytical standard of Pemetrexed (disodium heptahydrate). This product is intended for research and analytical applications. Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
    Pemetrexed disodium heptahydrate (Standard)
  • HY-P1103A
    CTCE-9908 TFA

    		CXCR Cancer
    CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .
    CTCE-9908 TFA
  • HY-P4757
    N1-Glutathionyl-spermidine disulfide

    		Parasite Others
    N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
    N1-Glutathionyl-spermidine disulfide
  • HY-P11293
    DOTA-GGNle-CycMSHhex

    		Melanocortin Receptor Cancer
    DOTA-GGNle-CycMSHhex is a melanocortin-1 receptor (MC1R)-targeting peptide that can be radionuclide-labeled for melanoma imaging .
    DOTA-GGNle-CycMSHhex
  • HY-P1321
    GR231118

    1229U91; GW1229

    		 Neuropeptide Y Receptor Neurological Disease
    GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8) .
    GR231118
  • HY-126830
    Antifolate C2

    		Antifolate Apoptosis Cancer
    Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed .
    Antifolate C2
  • HY-176011
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester

    17-Phenyl trinor PGF2α glycinamide methyl ester

    		 Prostaglandin Receptor Endocrinology
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a human prostaglandin FP receptor agonist. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma .
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester
  • HY-W403633
    Hexahydrohippuric acid

    		Bacterial Infection
    Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity .
    Hexahydrohippuric acid
  • HY-130205
    Milacemide hydrochloride

    CP 1552 S

    		 Monoamine Oxidase Neurological Disease
    Milacemide hydrochloride (CP 1552 S), a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide hydrochloride reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide hydrochloride is promising for research of Alzheimer's disease .
    Milacemide hydrochloride
  • HY-14522
    LY 222306

    		Antifolate Cancer
    LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
    LY 222306
  • HY-W005596
    5-Bromo-3-fluoropicolinic acid

    5-Bromo-3-fluoropyridine-2-carboxylic acid

    		 Drug Intermediate Others
    5-Bromo-3-fluoropicolinic acid (5-Bromo-3-fluoropyridine-2-carboxylic acid) is a drug synthesis intermediate that can be used to synthesize an inhibitor of glycinamide ribonucleotide formyltransferase .
    5-Bromo-3-fluoropicolinic acid
  • HY-10820S
    Pemetrexed-d5

    LY231514-d5

    		 Antifolate Autophagy Cancer
    Pemetrexed-d5 is the deuterium labeled Pemetrexed . Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed-d5
  • HY-10820AS
    Pemetrexed-d5 disodium

    LY231514-d5 disodium

    		 Isotope-Labeled Compounds Antifolate Autophagy Apoptosis Cancer
    Pemetrexed-d5 disodium is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed-d5 disodium
  • HY-13781R
    Pemetrexed disodium hemipenta hydrate (Standard)

    LY231514 disodium hemipenta hydrate (Standard)

    		 Antifolate Autophagy Apoptosis Reference Standards Cancer
    Pemetrexed (disodium hemipenta hydrate) (Standard) is the analytical standard of Pemetrexed (disodium hemipenta hydrate). This product is intended for research and analytical applications. Pemetrexed disodium hemipenta hydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
    Pemetrexed disodium hemipenta hydrate (Standard)
  • HY-W769288
    Pemetrexed disodium-13C5

    LY231514 disodium-13C5

    		 Isotope-Labeled Compounds Apoptosis Antifolate Autophagy Cancer
    Pemetrexed disodium- 13C5 (LY231514 disodium- 13C5) is the 13C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
    Pemetrexed disodium-13C5
  • HY-W101495S
    Boc-Leu-OH·H2O-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Boc-Leu-OH·H2O- 13C is a 13C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
    Boc-Leu-OH·H2O-13C
  • HY-P1321A
    GR231118 TFA

    1229U91 TFA; GW1229 TFA

    		 Neuropeptide Y Receptor Neurological Disease
    GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8) .
    GR231118 TFA
  • HY-176014
    17-Phenyl trinor prostaglandin F2α glycinamide

    17-Phenyl trinor PGF2α glycinamide

    		 Drug Derivative Others
    17-phenyl trinor PGF2α glycinamide (17-Phenyl trinor PGF2α glycinamide) is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide .
    17-Phenyl trinor prostaglandin F2α glycinamide
  • HY-182563
    Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide

    		Opioid Receptor Endocrinology
    Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide is a μ/δ opioid receptor ligand with high μ opioid receptor selectivity and agonist activity. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide has an IC50 of 237 nM for μ receptors and 1050 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide shows Ki values of 17 nM for μ receptors and 480 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of guinea pig ileum and mouse vas deferens. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide serves as a starting compound for structure-activity relationship investigations of μ receptor recognition .
    Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide
  • HY-10818R
    LY309887 (Standard)

    		Reference Standards Antifolate Cancer
    LY309887 (Standard) is the analytical standard of LY309887 (HY-10818). This product is intended for research and analytical applications. LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.
    LY309887 (Standard)
  • HY-P11480
    TrkA/NGF-IN-1

    		Trk Receptor Neurological Disease
    TrkA/NGF-IN-1 (Peptide 19) is an inhibitor of protein-protein interactions between TrkA and NGF (IC50: 21 nM for human TrkA in PathHunter assay). TrkA/NGF-IN-1 shows an analgesic effect in a rat incisional pain model .
    TrkA/NGF-IN-1

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