Oxytocin free acid TFA (Synonyms: 9-Deamidooxytocin TFA)

Cat. No.: HY-P3216B Purity: 99.61%: Data Sheet
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Oxytocin free acid (9-Deamidooxytocin) TFA is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior.

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Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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Based on 13 publication(s) in Google Scholar

Other Forms of Oxytocin free acid TFA:

Oxytocin In-stock
Oxytocin free acid Get quote

13 Publications Citing Use of MCE Oxytocin free acid TFA

RT-PCR

In Vivo Efficacy Study

: Oxytocin free acid TFA purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138. [Abstract]; Expression of OT (Oxytocin) signaling related genes in the hippocampus. RT-PCR analysis were performed on brain tissues from the hippocampus. Con: control; Veh: Vehicle (Saline); RIS: Risperidone; LOT: Low dose (6 μg/kg) of OT; MOT: Medium dose (20 μg/kg) of OT; HOT: High dose (60 μg/kg) of OTAfter 1 week of acclimation, animals in the control group were administered saline (10 ml/kg) and those in the model group were administered MK801 (0.6 mg/kg) through intraperitoneal (i. p.) injections once a day for 21 days. One week after MK801 administration, 6 μg/kg OT (LOT group, n = 10), 20 μg/kg OT (MOT group, n = 10), or 60 μg/kg OT (HOT group, n = 10) was given through the i.n. route twice daily, at 8:30–9:30 AM and 4:00–5:00 PM, for 14 days. Saline (0.2 μL/g) was administered intranasally in the control and vehicle groups. Then, the mice received an i.p. injection of MK801 30 min after OT administration. The mice in the RIS group received an i.p. injection of 0.3 mg/kg RIS once daily for 14 days

: Oxytocin free acid TFA purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138. [Abstract]; Effects of chronic intranasal OT (Oxytocin) on levels of spontaneous activity and anxiety-like behaviors in MK801-induced mice Fig. A, the total distance traveled by the mice in the open field test. Fig. 2B, the ratio of distance traveled in the central versus peripheral zone by the mice in the open field test. Con: control; Veh: Vehicle (Saline); RIS: Risperidone; LOT: Low dose (6 μg/kg) of OT; MOT: Medium dose (20 μg/kg) of OT; HOT: High dose (60 μg/kg) of OTAfter 1 week of acclimation, animals in the control group were administered saline (10 ml/kg) and those in the model group were administered MK801 (0.6 mg/kg) through intraperitoneal (i.p.) injections once a day for 21 days. One week after MK801 administration, 6 μg/kg OT (LOT group, n = 10), 20 μg/kg OT (MOT group, n =10), or 60 μg/kg OT (HOT group, n = 10) was giventhrough the i.n. route twice daily, at 8:30–9:30 AM and 4:00–5:00 PM, for 14 days. Saline (0.2 μL/g) was administered intranasally in the control and vehicle groups. Then, the mice received ani.p. injection of MK801 30 min after OT administration. The mice in the RIS group received an i.p. injection of 0.3 mg/kg RIS once daily for 14 days.

: Oxytocin free acid TFA purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84. [Abstract]; Effect of OT on CGRP and c-fos expression levels. A and C show c-fos, B and D show CGRP. Immunofluorescence staining showed that the number of c-fos-positive cells per FOV and the average fluorescence intensity of CGRP were significantly increased in the NTG + vehicle group compared with the sham group. OT administration significantly reduced the expression of CGRP and c-fos, while these effects were prevented after adding L368,899. Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

: Oxytocin free acid TFA purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84. [Abstract]; WB data quantification in the mouse trigeminal nucleus caudalis. Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

: Oxytocin free acid TFA purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84. [Abstract]; OT ameliorated pain sensitization and reduced neuronal activation via OTR. Note that L-368,899 was intraperitoneally injected daily 1 h before OT treatment. The mechanical and thermal pain thresholds of the hind paw and periorbital area were assessed before each NTG injection and on day 11. B, C, D The basal mechanical pain thresholds of the hind paw (B), periorbital area (C), and the thermal pain response of the hind paw (D) were significantly increased in the NTG + OT group compared with the NTG + vehicle group.The pain threshold in the NTG + OT + L368,899 group was markedly decreased compared with the NTG + OT group.Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

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Description

Molecular Weight

1122.20

Formula

C₄₅H₆₆F₃N₁₁O₁₅S₂

Appearance

Solid

Color

White to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (89.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8911 mL	4.4555 mL	8.9111 mL
5 mM	0.1782 mL	0.8911 mL	1.7822 mL
10 mM	0.0891 mL	0.4456 mL	0.8911 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

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Data Sheet (281 KB) SDS (252 KB)

COA (264 KB) HNMR (349 KB) LCMS (115 KB) Elemental Analysis Report (122 KB)

Handling Instructions (2659 KB)

References

[1]. Ferrier BM, et al. 9-Deamidooxytocin, an analog of the hormone containing a glycine residue in place of the glycinamide residue. J Med Chem. 1966;9(1):55-57. [Content Brief]

[2]. Carter CS, Kenkel WM, MacLean EL, et al. Is Oxytocin "Nature's Medicine"?. Pharmacol Rev. 2020;72(4):829-861. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8911 mL	4.4555 mL	8.9111 mL	22.2777 mL
	5 mM	0.1782 mL	0.8911 mL	1.7822 mL	4.4555 mL
	10 mM	0.0891 mL	0.4456 mL	0.8911 mL	2.2278 mL
	15 mM	0.0594 mL	0.2970 mL	0.5941 mL	1.4852 mL
	20 mM	0.0446 mL	0.2228 mL	0.4456 mL	1.1139 mL
	25 mM	0.0356 mL	0.1782 mL	0.3564 mL	0.8911 mL
	30 mM	0.0297 mL	0.1485 mL	0.2970 mL	0.7426 mL
	40 mM	0.0223 mL	0.1114 mL	0.2228 mL	0.5569 mL
	50 mM	0.0178 mL	0.0891 mL	0.1782 mL	0.4456 mL
	60 mM	0.0149 mL	0.0743 mL	0.1485 mL	0.3713 mL
	80 mM	0.0111 mL	0.0557 mL	0.1114 mL	0.2785 mL

Oxytocin free acid TFA Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxytocin free acid9-DeamidooxytocinOxytocin ReceptorOXTRanaloghormoneglycineresidueglycinamideInhibitorinhibitorinhibit

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Oxytocin free acid TFA (Synonyms: 9-Deamidooxytocin TFA)

Customer Review

Other Forms of Oxytocin free acid TFA:

Oxytocin free acid TFA Related Antibodies

13 Publications Citing Use of MCE Oxytocin free acid TFA

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Biological Activity

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References

Customer Review

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Complete Stock Solution Preparation Table

Oxytocin free acid TFA Related Classifications

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