137281-23-3
Chemical Structure
Pemetrexed
Synonym(s): LY231514
- CAS No.: 137281-23-3
- Formula:C20H21N5O6
- Molecular Weight:427.41
IUPAC Name: (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid
InChIKey: WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
SMILES: O=C1NC(N)=NC2=C1C(CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)=CN2
Biological Activity: Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pemetrexed | 99.91% | Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. | ||||||||||||||||||||
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Pemetrexed (Standard) | 99.09% | Pemetrexed (Standard) is the analytical standard of Pemetrexed. This product is intended for research and analytical applications. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. | ||||||||||||||||||||
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Pemetrexed-d5 | Pemetrexed-d5 is the deuterium labeled Pemetrexed. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. | |||||||||||||||||||||
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-
Similarity Score 0.84
HY-10820APemetrexed disodium -
Similarity Score 0.79
HY-137773N-Methyl pemetrexed -
Similarity Score 0.74
HY-1261195,10-Dideazafolic acid -
Similarity Score 0.74
HY-19095TNP-351 -
Similarity Score 0.74
HY-172935FR-β ligand 1 -
Similarity Score 0.73
HY-129976Pemetrexed tromethamine dihydrate -
Similarity Score 0.72
HY-178288TS-IN-7 -
Similarity Score 0.69
HY-175428Antifolate agent 1 -
Similarity Score 0.67
HY-147699FRα-IN-1 -
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