1. Cell Cycle/DNA Damage
  2. Antifolate

LY309887 

Cat. No.: HY-10818
Handling Instructions

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.

For research use only. We do not sell to patients.

LY309887 Chemical Structure

LY309887 Chemical Structure

CAS No. : 127228-54-0

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.

IC50 & Target

Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)[1]

In Vitro

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC50 of 9.9 nM[1].

In Vivo

LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2248 mL 11.1240 mL 22.2479 mL
5 mM 0.4450 mL 2.2248 mL 4.4496 mL
10 mM 0.2225 mL 1.1124 mL 2.2248 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

449.48

Formula

C₁₉H₂₃N₅O₆S

CAS No.

127228-54-0

SMILES

O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(CC[[email protected]@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
LY309887
Cat. No.:
HY-10818
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LY309887

Cat. No.: HY-10818