2. Cell Cycle/DNA Damage
  3. Antifolate
  4. LY309887

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.

For research use only. We do not sell to patients.

LY309887 Chemical Structure

LY309887 Chemical Structure

CAS No. : 127228-54-0

Size Price Stock Quantity
5 mg USD 384 In-stock
10 mg USD 620 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3390 In-stock
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Based on 1 publication(s) in Google Scholar

LY309887 Related Antibodies

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Description

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.

IC50 & Target

Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)[1]
In Vitro

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC50 of 9.9 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY309887 Related Antibodies
In Vivo

LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

449.48

Formula

C19H23N5O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (222.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2248 mL 11.1240 mL 22.2479 mL
5 mM 0.4450 mL 2.2248 mL 4.4496 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2248 mL 11.1240 mL 22.2479 mL 55.6198 mL
5 mM 0.4450 mL 2.2248 mL 4.4496 mL 11.1240 mL
10 mM 0.2225 mL 1.1124 mL 2.2248 mL 5.5620 mL
15 mM 0.1483 mL 0.7416 mL 1.4832 mL 3.7080 mL
20 mM 0.1112 mL 0.5562 mL 1.1124 mL 2.7810 mL
25 mM 0.0890 mL 0.4450 mL 0.8899 mL 2.2248 mL
30 mM 0.0742 mL 0.3708 mL 0.7416 mL 1.8540 mL
40 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.3905 mL
50 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1124 mL
60 mM 0.0371 mL 0.1854 mL 0.3708 mL 0.9270 mL
80 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6952 mL
100 mM 0.0222 mL 0.1112 mL 0.2225 mL 0.5562 mL
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LY309887 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY309887127228-54-0LY 309887LY-309887AntifolateInhibitorinhibitorinhibit

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