Search Result

Results for "

heavy chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (3) Adenosine Receptor (1) Adenylate Cyclase (1) Amino Acid Decarboxylase (1) AMPK (1) Amyloid-β (3) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) ANGPTL (2) Antifolate (1) Apoptosis (3) ATP Synthase (1) ATP-binding cassette (ABC) transporters (1) Autophagy (1) Bacterial (1) Bcl-2 Family (1) c-Fms (1) c-Met/HGFR (1) C-type Lectin-like Receptors (CTLRs) (2) Cadherin (3) Calcium Channel (1) CCR (3) CD19 (2) CD22 (1) CD276/B7-H3 (1) CD28 (1) CD3 (2) CD38 (1) CD47 (1) CGRP Receptor (1) Chloride Channel (1) Clathrin (2) Complement System (2) CRAC Channel (1) CTLA-4 (1) CXCR (10) Discoidin Domain Receptor (1) DNA/RNA Synthesis (1) Drug Derivative (1) Dynamin (2) E1/E2/E3 Enzyme (1) EGFR (3) Endothelin Receptor (1) Ephrin Receptor (1) Fc Receptor (FcR) (5) Ferroptosis (2) FGFR (3) G Protein-coupled Receptor Kinase (GRK) (1) GLUT (1) Glutathione Peroxidase (1) Glycosidase (1) HBV (1) HCV (3) Hepcidin (1) Histone Methyltransferase (1) IFNAR (1) Integrin (4) Interleukin Related (25) Isotope-Labeled Compounds (1) Kallikrein (1) LDLR (1) MDM-2/p53 (1) Mesothelin (1) Microtubule/Tubulin (1) MMP (1) Monoamine Oxidase (1) Myosin (4) nAChR (1) NAMPT (2) Neuropeptide Y Receptor (1) Notch (2) PACAP Receptor (1) PAI-1 (1) Parasite (1) PCSK9 (1) PD-1/PD-L1 (4) PDGFR (1) Phosphatase (1) PKA (1) Potassium Channel (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) RET (1) RSV (1) RUNX (1) Scavenger Receptor Class B type I (SR-BI） (1) Ser/Thr Protease (6) Smo (1) SOD (3) Sodium Channel (2) Tau Protein (1) TGF-beta/Smad (3) TGF-β Receptor (3) Thrombin (1) Thyroid Hormone Receptor (2) TNF Receptor (10) Toll-like Receptor (TLR) (3) Transmembrane Glycoprotein (18) TREM receptor (1) Trk Receptor (3) Tyrosinase (1) VEGFR (9) Wnt (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (9) Endocrinology (2) Infection (4) Inflammation/Immunology (306) Metabolic Disease (2) Neurological Disease (9)
Oligonucleotides:	Antisense Oligonucleotides (3)

203

Inhibitors & Agonists

Peptides

314

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Branched Chain Amino Acid Transaminase (BCAT) ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132580

Tofersen 2 Publications Verification BIIB067; ISIS-SOD1Rx; ISIS 333611	SOD	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-132580A

Tofersen sodium 2 Publications Verification BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium	SOD	Neurological Disease
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-P990608

Alpitatug IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6)	CD3	Inflammation/Immunology
Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990540

Anti-VEGFB Antibody (CSL346) CSL346; Reflocibart	VEGFR	Inflammation/Immunology
Anti-VEGFB Antibody (CSL346) is a CHO-expressed human antibody that targets VEGFB. Anti-VEGFB Antibody (CSL346) contains huIgG4SP heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-VEGFB Antibody (CSL346) can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-126236

3,5-Diiodothyropropionic acid 1 Publications Verification	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with K_a of 2.40 and 4.06 M ^-1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure .

HY-P991699

Lixarkitug AZD9829 antibody; INT-020	ADC Antibody Interleukin Related	Cancer
Lixarkitug (AZD9829 antibody; INT-020) is a humanized IgG1κ antibody targeting IL-3Ra/CD123. Lixarkitug can be conjugated with Samrotecan to form the intact ADC molecule lixarkitug samrotecan (AZD9829), which is used in studies of acute myeloid leukemia (AML) . The isotype control corresponding to Lixarkitug is Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990651

PY314	TREM receptor	Inflammation/Immunology
PY314 is a humanized antibody expressed in CHO, targeting TREM2. PY314 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for PY314 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990642

Oportuzumab	Transmembrane Glycoprotein	Inflammation/Immunology
Oportuzumab is a CHO-expressed humanized antibody that targets EpCAM/TROP1/CD326. Oportuzumab contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Oportuzumab can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990461

Anti-LIF Antibody (MSC-1) MSC-1	Interleukin Related	Inflammation/Immunology
Anti-LIF Antibody (MSC-1) is a CHO-expressed human antibody that targets LIF. Anti-LIF Antibody (MSC-1) contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 146.6 kDa. The isotype control for Anti-LIF Antibody (MSC-1) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990669

Torudokimab	Interleukin Related	Inflammation/Immunology
Torudokimab is a humanized antibody expressed in CHO, targeting IL-33. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P990312

ABT-325	Interleukin Related	Inflammation/Immunology
ABT-325 is a humanized antibody expressed in CHO that targets IL-18. ABT-325 has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.28 kDa. The isotype control for ABT-325 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990314

AFM24	EGFR	Inflammation/Immunology
AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 196.34 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990676

VIB-9600	Fc Receptor (FcR)	Inflammation/Immunology
VIB-9600 is a humanized antibody expressed in CHO cells, targeting FcgR2a/CD32a. VIB-9600 has a huIgG1 type heavy chain and huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for VIB-9600 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990571

Coltuximab 1 Publications Verification	CD19	Inflammation/Immunology
Coltuximab is a CHO-expressed humanized antibody that targets CD19. Coltuximab is composed of huIgG1 heavy chains and huκ light chains, with a molecular weight (MW) of 144.70 kDa. The isotype control for Coltuximab can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990587

FR104 1 Publications Verification	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990631

Mibavademab	Neuropeptide Y Receptor	Inflammation/Immunology
Mibavademab is a CHO-expressed humanized antibody that targets LEPR/CD295. Mibavademab is equipped with a huIgG4SP heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.58 kDa. The isotype control for Mibavademab can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P990480

Anti-oxLDL Antibody	LDLR	Inflammation/Immunology
The Anti-oxLDL Antibody is a humanized antibody expressed in CHO cells that targets oxLDL. The Anti-oxLDL Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-oxLDL Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990675

VGX-100	VEGFR	Inflammation/Immunology
VGX-100 is a humanized antibody expressed in CHO cells, targeting VEGFC. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990561

BT-063	Interleukin Related	Inflammation/Immunology
BT-063 is a humanized antibody expressed in CHO cells, targeting IL-10. BT-063 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for BT-063 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990620

LY3022856	VEGFR	Inflammation/Immunology
LY3022856 is a humanized antibody expressed in CHO, targeting VEGFR3/FLT4. LY3022856 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 146.18 kDa. The isotype control for LY3022856 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990352

Anti-CD36 Antibody Ona36	Scavenger Receptor Class B type I (SR-BI）	Inflammation/Immunology
Anti-CD36 Antibody is a humanized antibody expressed in CHO that targets CD36. The Anti-CD36 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD36 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990672

U3-1784 2 Publications Verification	FGFR	Inflammation/Immunology
U3-1784 is a humanized antibody expressed in CHO that targets FGFR4/CD334. U3-1784 is equipped with a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for U3-1784 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990439

Anti-IFNAR1 Antibody 2 Publications Verification	IFNAR	Inflammation/Immunology
The Anti-IFNAR1 Antibody is a humanized antibody expressed in CHO cells, targeting IFNAR1. The Anti-IFNAR1 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.92 kDa. The isotype control for the Anti-IFNAR1 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990351

Anti-CD34 Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-CD34 Antibody is a human-derived antibody expressed in CHO, targeting CD34. The Anti-CD34 Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-CD34 Antibody can be referenced from Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990645

PF-03732010	Cadherin	Inflammation/Immunology
PF-03732010 is a humanized antibody expressed in CHO, targeting CDH3/P-cadherin. PF-03732010 has a huIgG1 type heavy chain and a huλ type light chain, with a predicted molecular weight (MW) of 142.7 kDa. The isotype control for PF-03732010 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990818

*Anti-Rat FcRn heavy* chain heterodimers Antibody (1G3)**	Fc Receptor (FcR)	Inflammation/Immunology
Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat *FcRn heavy* chain heterodimers** IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-P991705

Nebaprubart JJP-1212	Fc Receptor (FcR)	Inflammation/Immunology
Nebaprubart (JJP-1212) is a humanized IgG4κ antibody against FCAR/CD89, and its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003) .

HY-P990572

DCBY02 1 Publications Verification	Transmembrane Glycoprotein	Inflammation/Immunology
DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.

HY-P990088

Sotiburafusp alfa	VEGFR PD-1/PD-L1	Cardiovascular Disease
Sotiburafusp alfa is a bispecific fusion protein, which is a humanized VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) fused via the peptide linker ¹⁰¹GGSGGSGGSGGSGGS ¹¹⁵ to the N-terminus of the heavy chain (116-564) of a humanized IgG1-kappa anti-human PD-L1 heavy chain variant L352>A, L353>A. Sotiburafusp alfa also functions as a PD-L1 inhibitor and a VEGF inhibitor .

HY-P990662

Sapelizumab	Interleukin Related	Inflammation/Immunology
Sapelizumab is a CHO-expressed humanized antibody targeting IL-6Ra/CD126. Sapelizumab has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Sapelizumab can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990614

LK-1	Myosin	Inflammation/Immunology
LK-1 is a humanized antibody expressed in CHO that targets S100A4. LK-1 carries a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for LK-1 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990405

Anti-EphB2 Antibody	Ephrin Receptor	Inflammation/Immunology
The Anti-EphB2 Antibody is a CHO expressed human antibody that targets EphB2. The Anti-EphB2 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-EphB2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990349

Anti-CD19 Antibody	CD19	Inflammation/Immunology
The Anti-CD19 Antibody is a humanized antibody expressed in CHO cells, targeting CD19. The Anti-CD19 Antibody contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-CD19 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990647

PF-06342674	Interleukin Related	Inflammation/Immunology
PF-06342674 is a CHO-expressed humanized antibody that targets IL-7Ra/CD127. PF-06342674 carries a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145.14 kDa. The isotype control for PF-06342674 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990356

Anti-CD59 Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-CD59 Antibody is a CHO-expressed humanized antibody that targets CD59. The Anti-CD59 Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD59 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990559

BMS-986178	TNF Receptor	Inflammation/Immunology
BMS-986178 is a humanized antibody expressed in CHO, targeting TNFRSF4/OX40/CD134. BMS-986178 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for BMS-986178 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990517

Anti-TGFb1 Antibody	TGF-beta/Smad	Inflammation/Immunology
Anti-TGFb1 Antibody is a humanized antibody expressed in CHO cells that targets TGFb1. The Anti-TGFb1 Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-TGFb1 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990532

Anti-TPBG Antibody	Wnt	Inflammation/Immunology
Anti-TPBG Antibody is a humanized antibody expressed in CHO cells, targeting TPBG. The Anti-TPBG Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.8 kDa. The isotype control for Anti-TPBG Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990638

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 lambda, Isotype Control (HY-P991206).

HY-P990497

Anti-RAMP3 Antibody	CGRP Receptor	Inflammation/Immunology
Anti-RAMP3 Antibody is a CHO expressed human antibody that targets RAMP3. The Anti-RAMP3 Antibody features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-RAMP3 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991105

*Anti-Clathrin Heavy* Chain Antibody**	Dynamin	Others
Anti-Clathrin Heavy Chain Antibody is a human antibody expressed in CHO cells, targeting Clathrin Heavy Chain. Anti-Clathrin Heavy Chain Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-125966

AI-4-57	RUNX	Cancer
AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC₅₀ of 22 μM .

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇	Isotope-Labeled Compounds SOD	Neurological Disease
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

HY-P991672

Anflekitug	Interleukin Related	Inflammation/Immunology
Anflekitug is a CHO-expressed human antibody that targets IL-1β. Anflekitug has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anflekitug can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P10612A

Tetanus toxin (1301-1315) (C. tetani)	Bacterial	Infection Inflammation/Immunology
Tetanus toxin (1301-1315) (C. tetani) is a C-terminal peptide fragment of tetanus toxin heavy chain from C. tetani. Tetanus toxin (1301-1315) (C. tetani) can be used for the researches of infection and immunology .

HY-P990467

Anti-MICB Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-MICB Antibody is a humanized antibody expressed in CHO cells, targeting MICB. The Anti-MICB Antibody contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.66 kDa. The isotype control for the Anti-MICB Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990474

Anti-NGF/bNGF Antibody AS2886401-00	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets NGF/bNGF. Anti-NGF/bNGF Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990473

Anti-MUSK Antibody	Trk Receptor	Inflammation/Immunology
Anti-MUSK Antibody is a humanized antibody expressed in CHO that targets MUSK. The Anti-MUSK Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 143.86 kDa. For the isotype control of Anti-MUSK Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).

HY-P990360

Anti-CD9 Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-CD9 Antibody is a humanized antibody expressed in CHO, targeting CD9. The Anti-CD9 Antibody is equipped with huIgG1 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 145.98 kDa. The isotype control for Anti-CD9 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990434

Anti-Histone H3 Antibody	Histone Methyltransferase	Inflammation/Immunology
The Anti-Histone H3 Antibody is a CHO-expressed humanized antibody that targets Histone H3. The Anti-Histone H3 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-Histone H3 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Target	Research Area

HY-P2464

Myosin H Chain Fragment, mouse 3 Publications Verification	Peptides	Inflammation/Immunology
Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model .

HY-P0064

Palmitoyl Tetrapeptide-3 Palmitoyl Tetrapeptide-7	Interleukin Related	Inflammation/Immunology
Palmitoyl Tetrapeptide-3 (Palmitoyl Tetrapeptide-7) is a synthetic peptide corresponding to amino acids 341-344 of the human immunoglobulin heavy chain, with the ability to stimulate phagocytosis. Palmitoyl tetrapeptide-3 reduces interleukin-6 (IL-6) secretion in keratinocytes and inhibits the UVB radiation-exposure inflammatory response of skin. Palmitoyl tetrapeptide-3 It also has anti-inflammatory and anti-aging effects, reducing skin wrinkles by promoting the production of elastic fibers in the papillary dermis .

HY-P10554

Myhc-α(334–352)	Peptides	Cardiovascular Disease Others Inflammation/Immunology
Myhc-α(334–352) is a sequence fragment of amino acid residues 334 to 352 of cardiac myosin heavy chain α. Myhc-α(334–352) is an immunodominant epitope that can induce autoimmune reactions in A/J mice, leading to the occurrence of myocarditis. Myhc-α(334–352) can be used to study the autoimmune pathways of myocarditis and dilated cardiomyopathy .

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

HY-P10612A

Tetanus toxin (1301-1315) (C. tetani)	Bacterial	Infection Inflammation/Immunology
Tetanus toxin (1301-1315) (C. tetani) is a C-terminal peptide fragment of tetanus toxin heavy chain from C. tetani. Tetanus toxin (1301-1315) (C. tetani) can be used for the researches of infection and immunology .

HY-P2464A

Myosin H Chain Fragment, mouse acetate	Peptides	Cardiovascular Disease
Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model .

HY-P4510

SLSLSPG	Peptides	Others
SLSLSPG can be obtained from the C-end of the heavy chain of human Igγ-1. SLSLSPG is a common variant in IgG .

HY-P11373

α-Myosin (614-643)	Myosin	Cardiovascular Disease Inflammation/Immunology
α-Myosin (614-643) is a segment of polypeptide of the heavy chain of cardiac α-myosin. α-Myosin has a strong ability to induce autoimmune myocarditis .

HY-P3051A

CKS-17 (dimer)	Drug Derivative	Infection Inflammation/Immunology
CKS-17 (dimer) is the dimer of CKS-17 (HY-P3051). CKS-17 (dimer) can be prepared by introducing a naturally occurring cysteine at the carboxyl terminus and dimerizing via a cysteine-disulfide bond. CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has a highly conserved amino acid sequence present in the transmembrane envelope proteins of numerous animal and human retroviruses. As an immunomodulatory epitope, CKS-17 exhibits inhibitory properties on a variety of immune functions .

Species:	Human (18) Rat (2) Mouse (1) Pig (2)
Tag:	His (14) Tag Free (5) Avi (2) GST (1) Fc (2)
Source:	HEK293 (12) Sf9 insect cells (1) P. pastoris (2) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75367

	CD98 Protein, Mouse (HEK293, His) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Mouse	HEK293
	CD98 is a multifunctional protein predicted to function as an amino acid transmembrane transporter and to have double-stranded RNA binding activity.It is involved in carboxylic acid transport and virus entry, acting upstream of the dsRNA response, suggesting that it has multiple functions.CD98 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD98 protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P75368

	CD98 Protein, Human (HEK293, His) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Human	HEK293
	The CD98 protein acts as a chaperone, promoting the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms heterodimers with various SLC7 family transporters and affects the substrate specificity of amino acid antiporters. CD98 Protein, Human (HEK293, His) is the recombinant human-derived CD98 protein, expressed by HEK293 , with N-His labeled tag.

HY-P72192

	FCGRT Protein, Human (GST) Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor	Human	E. coli
	The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT Protein, Human (GST) is the recombinant human-derived FCGRT protein, expressed by E. coli , with N-GST labeled tag.

HY-P705914

	FCGRT Protein, Human (His) Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor	Human	E. coli
	The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT Protein, Human (GST) is the recombinant human-derived FCGRT protein, expressed by E. coli , with N-GST labeled tag.

HY-P75663

	CD98 Protein, Rat (HEK293, Fc) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Rat	HEK293
	The CD98 protein is a molecular chaperone that facilitates the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms a heterodimer with SLC7 family transporters and acts as an amino acid antiporter, whose substrate specificity is determined by the SLC7A subunit. CD98 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD98 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P75664

	CD98 Protein, Rat (HEK293, His) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Rat	HEK293
	The CD98 protein is a molecular chaperone that facilitates the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms a heterodimer with SLC7 family transporters and acts as an amino acid antiporter, whose substrate specificity is determined by the SLC7A subunit. CD98 Protein, Rat (HEK293, His) is the recombinant rat-derived CD98 protein, expressed by HEK293 , with N-His labeled tag.

HY-P70246

	*Ferritin heavy* chain/FTH1 Protein, Human** 1 Publications Verification rHuFerritin heavy chain/FTH1; Ferritin heavy chain; FTH1; FTH; FTHL6; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	Human	E. coli
	The ferritin heavy chain/FTH1 protein is critical for maintaining iron homeostasis, storing iron in soluble form through ferroxidase activity. It promotes the oxidation of ferrous iron so that it can be deposited in the form of iron hydroxide. Ferritin heavy chain/FTH1 Protein, Human is the recombinant human-derived Ferritin heavy chain/FTH1 protein, expressed by E. coli , with tag free.

HY-P70407

	ITIH3 Protein, Human (HEK293, His) rHuInter-alpha-trypsin inhibitor heavy chain H3/ITIH3/, His; Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; Serum-derived hyaluronan-associated protein; SHAP	Human	HEK293
	The ITIH3 protein has a dual role: as a carrier of hyaluronic acid in serum and as a binding protein that facilitates interactions with various matrix proteins. These interactions regulate the localization, synthesis, and degradation of hyaluronic acid, which is critical for multiple cellular activities. ITIH3 Protein, Human (HEK293, His) is the recombinant human-derived ITIH3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71939

	Plasminogen Protein, Human Plasmin; Plasmin heavy chain A; Plasmin light chain B; Plasminogen; PLG; PLMN_HUMAN	Human	E. coli
	Plasminogen protein is the key precursor of plasmin and plays a central role in a variety of physiological and pathological processes. Plasmin is derived from plasminogen and dissolves fibrin during blood coagulation, affecting embryonic development, tissue remodeling, tumor invasion and inflammation. Plasminogen Protein, Human is the recombinant human-derived Plasminogen protein, expressed by E. coli , with tag free.

HY-P705958

	ApoFerritin Protein, Human (E63A) ApoFerritin; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein; Ferritin heavy chain, N-terminally processed; FTH1; FTH; THL6; OK/SW-cl.84, PIG15	Human	E. coli

HY-P72189

	Coagulation Factor XII/F12 Protein, Pig (His) F12 Coagulation factor XII; EC 3.4.21.38; Hageman factor; HAF; Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain	Pig	E. coli
	Coagulation factor XII (F12) is a serum glycoprotein that plays multiple roles in initiating blood coagulation, fibrinolysis, and the production of bradykinin and angiotensin. It is involved in these complex processes, including cleavage of prekallikrein to form kallikrein, which subsequently cleaves factor XII initially to α-factor XIIa and then, after trypsin cleavage, to β-factor XIIa. Coagulation Factor XII/F12 Protein, Pig (His) is the recombinant pig-derived Coagulation Factor XII/F12 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700599

	Coagulation Factor XII/F12 Protein, Pig (P. pastoris, His) F12 Coagulation factor XII; EC 3.4.21.38; Hageman factor; HAF; Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain	Pig	P. pastoris
	Coagulation factor XII (F12) is a serum glycoprotein that plays multiple roles in initiating blood coagulation, fibrinolysis, and the production of bradykinin and angiotensin. It is involved in these complex processes, including cleavage of prekallikrein to form kallikrein, which subsequently cleaves factor XII initially to α-factor XIIa and then, after trypsin cleavage, to β-factor XIIa. Coagulation Factor XII/F12 Protein, Pig (P. pastoris, His) is the recombinant pig-derived F12/Coagulation Factor XII, Pig, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70231

	Coagulation factor IX/F9 Protein, Human (HEK293, His) rHuCoagulation factor IX/F9, His; F9; Coagulation factor IX; Christmas factor; Plasma thromboplastin component; Coagulation factor IXa light chain; Coagulation factor IXa heavy chain	Human	HEK293
	Factor IX (F9) is a vitamin K-dependent plasma protein that plays a critical role in the intrinsic pathway of coagulation. Factor IX coordinates the conversion of factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Coagulation factor IX/F9 Protein, Human (HEK293, His) is the recombinant human-derived Coagulation factor IX/F9 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P703725

	CD98 Protein, Human (HEK293, hFc) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Human	HEK293
	CD98 Protein, Human (HEK293, hFc) is the recombinant human-derived CD98 protein, expressed by HEK293, with N-hFc tag.

HY-P703724

	CD98 Protein, Human (HEK293, His, Avi) 4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2	Human	HEK293
	CD98 Protein, Human (HEK293, His, Avi) is the recombinant human-derived CD98 protein, expressed by HEK293, with N-His & Avi tag.

HY-P704090

	IgG2 Fc Protein, Human (HEK293) Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc	Human	HEK293
	The IgG2 Fc protein is the constant region of the immunoglobulin heavy chain and acts as an antigen receptor, triggering the expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG2 Fc Protein, Human (HEK293) is the recombinant human-derived IgG2 Fc protein, expressed by HEK293, with tag free.

HY-P70532

	S100A9 Protein, Human 1 Publications Verification Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; MRP-14; CAGB; CFAG	Human	E. coli
	S100A9 Protein is an acidic protein. S100A9 Protein activates pro-inflammatory signaling pathways by binding to TLR4/MD2 and RAGE receptors, regulating transcription factors such as NF-κB, CREB-1, STAT3/STAT5, etc. S100A9 Protein forms a heterodimer (calprotectin) with S100A8. S100A9 Protein enhances cytokine secretion under inflammatory stimulation, promotes immune cell migration, regulates vascular endothelial permeability, induces tumor cell apoptosis, and exerts antibacterial effects through metal ion chelation.

HY-P70532A

	S100A9 Protein, Human (His) Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; MRP-14; CAGB; CFAG	Human	E. coli
	The S100A9 protein is a calcium and zinc binder that plays a critical regulatory role in inflammation and immune responses. Its diverse functions include induction of neutrophil chemotaxis, adhesion, enhanced bactericidal activity through SYK, PI3K/AKT and ERK1/2 activation, and promotion of phagocytosis. S100A9 Protein, Human (His) is the recombinant human-derived S100A9 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705219

	IgG2 Fc Protein, Human (Biotinylated, HEK293, Avi) Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc	Human	HEK293

HY-P72605

	IgG2 Fc Protein, Human (V161M, S257A, HEK293) Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc	Human	HEK293
	The IgG2 Fc protein is the constant region of the immunoglobulin heavy chain and acts as an antigen receptor, triggering the expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells.IgG2 Fc Protein, Human (V161M, S257A, HEK293) is the recombinant human-derived IgG2 Fc protein, expressed by HEK293 , with tag free.

HY-P790088

	HSPA5/GRP-78 Protein, Human (sf9, His) Binding-immunoglobulin protein; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; HSPA5; GRP78	Human	Sf9 insect cells
	HSPA5/GRP-78 is an endoplasmic reticulum chaperone that coordinates protein folding and quality control. It cooperates with DNAJC10/ERdj5 to facilitate correct protein folding and participates in the degradation of misfolded proteins, potentially releasing DNAJC10/ERdj5. HSPA5/GRP-78 Protein, Human (sf9, His) is the recombinant human-derived HSPA5, expressed by Sf9 insect cells, with C-10*His labeled tag.

HY-P72161

	CYBB/Nox2 Protein, Human (His) AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245; beta polypeptide; Cytochrome b558; beta chain; Cytochrome b558; subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox;	Human	E. coli
	The CYBB/Nox2 protein is an important membrane-bound oxidase in phagocytes and is critical for superoxide production. As the terminal element of the respiratory chain, it transfers a single electron from NADPH to molecular oxygen. CYBB/Nox2 Protein, Human (His) is the recombinant human-derived CYBB/Nox2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704486

	HSPA5/GRP-78 Protein, Human (P.pastoris, His) Endoplasmic reticulum chaperone BiP; HSPA5; 78 kDa glucose-regulated protein; Binding-immunoglobulin protein; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; GRP78	Human	P. pastoris
	HSPA5/GRP-78 is an endoplasmic reticulum chaperone that coordinates protein folding and quality control. It cooperates with DNAJC10/ERdj5 to facilitate correct protein folding and participates in the degradation of misfolded proteins, potentially releasing DNAJC10/ERdj5. HSPA5/GRP-78 Protein, Human (P.pastoris, His) is the recombinant human-derived HSPA5/GRP-78 protein, expressed by P. pastoris, with C-6*His labeled tag.

HY-P705984

	HSPA5/GRP-78 Protein, Cricetulus griseus (HEK293, His) Endoplasmic reticulum chaperone BiP; EC:3.6.4.10; 8 kDa glucose-regulated protein; Binding-immunoglobulin protein; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein ; HSPA5; GRP78; I79_019946	Others	HEK293

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Cat. No.	Product Name	Chemical Structure

HY-132580S

Tofersen-d27

Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

Host:	Mouse (11) Rabbit (39) Goat (12)
Reactivity:	Human (45) FruitFly (1) Rat (30) Mouse (48) Rabbit (1) Nematode (1) Hamster (2)
Application:	IHC-P (38) ICC/IF (25) mIHC (2) IF-Tissue (20) IP (13) IHC-F (9) WB (46) FC (15) ELISA (23)
Isotype:	IgG3,IgG/Kappa (1) IgG (41) IgG1 (3) IgG2b (2)
Conjugation:	Cy7 (1) Cy5.5 (1) AF 594 (1) AF 750 (1) AF 790 (1) AF 680 (1) Biotin (1) AF 647 (1) AF 488 (1) AF 555 (1) Non-conjugated (50) Cy3 (1) TRITC (1) Cy5 (1)
Clonality:	Polyclonal (15) Monoclonal (39) Recombinant (23)
Modification:	Unmodified (42)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83455

	*Myosin heavy* chain Antibody (YA3200)** MYH6; MYHC; MYHCA; MYHCB; Myosin heavy chain 6; Myosin heavy chain; Myosin-6; Myosin heavy chain; cardiac muscle alpha isoform	WB, IHC-P	Human, Mouse, Rat
	Myosin heavy chain Antibody (YA3200) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin heavy chain.

HY-P85963

	*Myosin Heavy* Chain Smooth Muscle Antibody (YA5655)** Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Myosin Heavy Chain Smooth Muscle Antibody (YA5655) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P86043

	*Myosin Heavy* Chain Smooth Muscle Antibody (YA5735)** Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC;	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Myosin Heavy Chain Smooth Muscle Antibody (YA5735) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P80086

	*Clathrin Heavy* Chain Antibody (YA501)**	WB, IHC-P	Human, Mouse, Rat
	Clathrin Heavy Chain Antibody (YA501) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Clathrin Heavy Chain.

HY-P85656

	*Myosin Heavy* Chain Antibody (YA5348)**	ICC/IF	Human, Mouse, Rat, FruitFly, Nematode
	Myosin Heavy Chain Antibody (YA5348) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Myosin Heavy Chain.

HY-P86581

	*Clathrin Heavy* Chain Antibody (YA6273)**	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Clathrin Heavy Chain Antibody (YA6273) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Clathrin Heavy Chain.

HY-P81875

	*Myosin Heavy* Chain Smooth Muscle Antibody (YA1620)** AAT4; FAA4; MYH11; Myosin 11; Myosin heavy chain 11; Myosin heavy chain smooth muscle isoform; Myosin heavy polypeptide 11 smooth muscle; SMHC; SMMHC	WB, IHC-P	Human, Mouse
	Myosin Heavy Chain Smooth Muscle Antibody (YA1620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P83782

	*Fast Myosin Skeletal Heavy* chain Antibody(YA3479)** adult 1 antibody; MYH1 antibody; MYH1_HUMAN antibody; MyHC-2x antibody; MyHC-IIx/d antibody; Myosin heavy chain 1 antibody; Myosin heavy chain 2x antibody; Myosin heavy chain antibody; Myosin heavy chain IIx/d antibody; Myosin-1 antibody; skeletal muscle antibody	IHC-P, IF-Tissue	Human, Mouse, Rat
	Fast Myosin Skeletal Heavy chain Antibody(YA3479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fast Myosin Skeletal Heavy chain.

HY-P80234

	*Myosin heavy* chain Antibody (YA279)** cardiac muscle alpha isoform antibody; MYH6 antibody; MYH6_HUMAN antibody; MYH7 antibody; MYHC antibody; MyHC-alpha antibody; MyHC-beta antibody; MYHCA antibody; MYHCB antibody; Myosin heavy chain 6 antibody; Myosin heavy chain antibody; Myosin heavy chain cardiac muscle alpha isoform antibody; Myosin heavy chain cardiac muscle beta isoform antibody; Myosin-6 antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	Myosin heavy chain Antibody (YA279) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin heavy chain.

HY-P83369

	MYH10 Antibody (YA3114) NMMHCB; NMMHC-IIB; Myosin-10, Myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P83369A

	MYH10 Antibody (YA3114)(PBS only) NMMHCB; NMMHC-IIB; Myosin-10, Myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P85687

	*Rabbit IgG (Fc specific_Heavy Chain) Antibody (YA5379)*	WB	Rabbit
	Rabbit IgG (Fc specific_Heavy Chain) Antibody (YA5379) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Rabbit IgG (Fc specific_Heavy Chain).

HY-P89381

	TRITC-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IHC-P, IF-Tissue, FC, ELISA	Mouse
	TRITC-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is a TRITC-conjugated, Goat-derived anti-Mouse antibody. TRITC-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P87094

	*Slow Skeletal Myosin Heavy* chain Antibody (YA6787)** Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; MYHCB antibody; Myopathy, distal 1 antibody; Myosin heavy chain (AA 1-96) antibody; Myosin heavy chain 7 antibody; Myosin heavy chain antibody; Myosin heavy chain slow isoform antibody; Myosin heavy chain, cardiac muscle beta isoform antibody; Myosin, heavy chain 7, cardiac muscle, beta antibody; Myosin, heavy polypeptide 7, cardiac muscle, beta antibody; Myosin-7 antibody; Rhabdomyosarcoma antigen MU RMS 40.7A antibody; SPMD antibody; SPMM antibody;	WB, IHC-P, IF-Tissue, IHC-F	Human, Mouse, Rat
	Slow Skeletal Myosin Heavy chain Antibody (YA6787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Slow Skeletal Myosin Heavy chain.

HY-P89382

	Cy3-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IHC-P, IF-Tissue, FC, ELISA	Mouse
	Cy3-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is a Cy3-conjugated, Goat-derived anti-Mouse antibody. Cy3-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89383

	Cy5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IHC-P, IF-Tissue, FC, ELISA	Mouse
	Cy5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is a Cy5-conjugated, Goat-derived anti-Mouse antibody. Cy5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89385

	Cy7-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IHC-P, IF-Tissue, FC, ELISA	Mouse
	Cy7-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is a Cy7-conjugated, Goat-derived anti-Mouse antibody. Cy7-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89386

	AF488-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF488-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF488-conjugated, Goat-derived anti-Mouse antibody. AF488-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89387

	AF647-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF647-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF647-conjugated, Goat-derived anti-Mouse antibody. AF647-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89388

	AF594-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF594-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF594-conjugated, Goat-derived anti-Mouse antibody. AF594-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89389

	AF555-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF555-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF555-conjugated, Goat-derived anti-Mouse antibody. AF555-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89390

	AF750-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF750-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF750-conjugated, Goat-derived anti-Mouse antibody. AF750-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89391

	AF680-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	WB, IF-Tissue, FC	Mouse
	AF680-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF680-conjugated, Goat-derived anti-Mouse antibody. AF680-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89392

	AF790-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IF-Tissue, FC, ELISA	Mouse
	AF790-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is an AF790-conjugated, Goat-derived anti-Mouse antibody. AF790-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P89384

	Cy5.5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain	IHC-P, IF-Tissue, FC, ELISA	Mouse
	Cy5.5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain is a Cy5.5-conjugated, Goat-derived anti-Mouse antibody. Cy5.5-conjugated Goat Anti-Mouse IgM Mu Heavy Chain conjugates mouse IgM Mu Heavy Chain.

HY-P86969

	MYH2 Antibody (YA6662) adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; MyHC-IIa antibody; MYHSA2 antibody; Myosin heavy chain 2 antibody; Myosin heavy chain 2a antibody; Myosin heavy chain antibody; Myosin heavy chain IIa antibody; Myosin heavy chain skeletal muscle adult 2 antibody; Myosin heavy polypeptide 2 skeletal muscle adult antibody; Myosin-2 antibody; MYPOP antibody; skeletal muscle antibody; Type IIA myosin heavy chain antibody;	WB, IHC-P	Human, Mouse, Rat
	MYH2 Antibody (YA6662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH2.

HY-P80670

	*Ferritin Heavy* Chain Antibody (YA443)** 5+ Cited Publications FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, ICC/IF	Human, Mouse, Rat, Hamster
	Ferritin Heavy Chain Antibody (YA443) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin Heavy Chain.

HY-P86448

	*Ferritin heavy* chain Antibody (YA6140)** FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Ferritin heavy chain Antibody (YA6140) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin heavy chain.

HY-P86406

	*Ferritin Heavy* Chain Antibody (YA6098)** FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	Ferritin Heavy Chain Antibody (YA6098) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin Heavy Chain.

HY-P80670A

	*Ferritin Heavy* Chain Antibody (YA443)(PBS only)** FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, ICC/IF	Human, Mouse, Rat, Hamster
	Ferritin Heavy Chain Antibody (YA443) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin Heavy Chain.

HY-P86926

	IgD Antibody (YA6619) Immunoglobulin heavy constant delta Ig delta chain C region Ig delta chain C region NIG-65 Ig delta chain C region WAH IGHD	WB, IHC-P, IF-Tissue	Human
	IgD Antibody (YA6619) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IgD.

HY-P85879

	Annexin-2/ANXA2 Antibody (YA5571) Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Annexin-2/ANXA2 Antibody (YA5571) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to Annexin-2/ANXA2.

HY-P86836

	Cathepsin H Antibody (YA6529) Pro-cathepsin H Cathepsin H mini chain Cathepsin H EC:3.4.22.16 Cathepsin H heavy chain Cathepsin H light chain CTSH CPSB	WB, ICC/IF	Human
	Cathepsin H Antibody (YA6529) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cathepsin H.

HY-P81194

	EPX Antibody Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN.	IHC-P, IHC-F, ICC/IF	Human, Mouse
	EPX Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to EPX.

HY-P81608

	Factor IX Antibody (YA1353) Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]	WB	Human
	Factor IX Antibody (YA1353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor IX.

HY-P81219

	MPO Antibody Myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	MPO Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MPO.

HY-P81604

	Factor X Antibody (YA1349) Activated factor Xa heavy chain; Coagulation factor X; F10; factor Xa; FXA; Prothrombinase; Stuart factor	WB, IHC-P	Human
	Factor X Antibody (YA1349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor X.

HY-P82149

	S100 alpha9 Antibody (YA1894) S100 alpha9; Calgranulin-B; Leukocyte L1 complex heavy chain	WB, IHC-F, IHC-P, ICC/IF	Mouse
	S100 alpha9 Antibody (YA1894) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S100 alpha9.

HY-P83153

	GCLC Antibody (YA2898) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P81219A

	MPO Antibody(YA3392) Myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	WB, IHC-P, ICC/IF, IF-Tissue, mIHC	Human, Mouse, Rat
	MPO Antibody(YA3392) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to MPO.

HY-P83736

	MPO Antibody (YA3466) Myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	MPO Antibody (YA3466) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MPO.

HY-P86305

	GCLC Antibody (YA5997) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GCLC Antibody (YA5997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P82966

	Annexin-2/ANXA2 Antibody (YA2711) ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36	WB, IHC-P, IP, FC	Human, Mouse, Rat
	Annexin-2/ANXA2 Antibody (YA2711) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Annexin-2/ANXA2.

HY-P83577

	MHC Class I Antibody (YA3322) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC class I antigen HLA A heavy* chain	WB, IHC-P	Human
	MHC Class I Antibody (YA3322) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MHC Class I.

HY-P82149A

	S100 alpha9 Antibody (YA1894)(PBS only) S100 alpha9; Calgranulin-B; Leukocyte L1 complex heavy chain	WB, IHC-F, IHC-P, ICC/IF	Mouse
	S100 alpha9 Antibody (YA1894) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S100 alpha9.

HY-P82966A

	Annexin-2/ANXA2 Antibody (YA2711)(PBS only) ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36	WB, IP	Human
	Annexin-2/ANXA2 Antibody (YA2711) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Annexin-2/ANXA2.

HY-P83153A

	GCLC Antibody (YA2898)(PBS only) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P83577A

	MHC Class I Antibody (YA3322)(PBS only) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC class I antigen HLA A heavy* chain	WB, IHC-P	Human
	MHC Class I Antibody (YA3322) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MHC Class I.

HY-P83195

	HLA Class 1 A Antibody (YA2940) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC class I antigen HLA A heavy* chain	WB, IHC-P, ICC/IF, IP, FC	Human
	HLA Class 1 A Antibody (YA2940) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HLA Class 1 A.

HY-P87174

	NOX2 Antibody (YA6865) CYBB; NOX2; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b; 558; subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
	NOX2 Antibody (YA6865) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOX2.

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Cat. No.	Product Name		Classification

HY-132580

Tofersen 2 Publications Verification BIIB067; ISIS-SOD1Rx; ISIS 333611		Antisense Oligonucleotides
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-132580A

Tofersen sodium 2 Publications Verification BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium		Antisense Oligonucleotides
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇		Antisense Oligonucleotides
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

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