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human β-CGRP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CGRP Receptor (5)
By Research Areas:	Cardiovascular Disease (3) Inflammation/Immunology (3) Neurological Disease (2)

Inhibitors & Agonists

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15498

Rimegepant Maximum Cited Publications 10 Publications Verification BMS-927711; BHV-3000	CGRP Receptor	Neurological Disease
Rimegepant (BMS-927711) is an orally bioavailable and blood-brain barrier permeable antagonist of *CGRP* and AMY1 receptors, with a pIC₅₀ of 8.01 and a K_i of 0.027 nM for human *CGRP* receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at *CGRP* and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .

HY-P1548

**β-CGRP, human** 1 Publications Verification human β-CGRP; CGRP-II (human)	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

HY-P1548A

β-CGRP, human TFA 1 Publications Verification human β-CGRP TFA; CGRP-II (human) TFA	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

HY-P99017

Eptinezumab ALD-403	CGRP Receptor	Neurological Disease
Eptinezumab (ALD-403) is a human monoclonal antibody targeting the α and β subtypes of human calcitonin gene-related peptide (CGRP). Eptinezumab binds to the *CGRP* ligand and blocks its binding to endogenous *CGRP* receptors, thereby inhibiting receptor activation. Eptinezumab can be used in research related to migraine .

HY-P1548B

β-CGRP, human acetate human β-CGRP acetate; CGRP-II (human) acetate	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

Cat. No.	Product Name	Target	Research Area

HY-P1548

**β-CGRP, human** 1 Publications Verification human β-CGRP; CGRP-II (human)	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

HY-P1548A

β-CGRP, human TFA 1 Publications Verification human β-CGRP TFA; CGRP-II (human) TFA	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

HY-P1548B

β-CGRP, human acetate human β-CGRP acetate; CGRP-II (human) acetate	CGRP Receptor	Cardiovascular Disease Inflammation/Immunology
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99017

Eptinezumab ALD-403	CGRP Receptor	Neurological Disease
Eptinezumab (ALD-403) is a human monoclonal antibody targeting the α and β subtypes of human calcitonin gene-related peptide (CGRP). Eptinezumab binds to the *CGRP* ligand and blocks its binding to endogenous *CGRP* receptors, thereby inhibiting receptor activation. Eptinezumab can be used in research related to migraine .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75600

	CALCB Protein, Human (HEK293, mFc) Calcitonin gene-related peptide 2; CALC2; Beta-CGRP; CGRP-II	Human	HEK293
	CALCB, known for its vasodilatory effects, induces dilation in various vessels, encompassing the coronary, cerebral, and systemic vasculature. Its notable abundance in the central nervous system suggests a potential role as a neurotransmitter or neuromodulator, underscoring its significance in physiological processes related to vascular regulation and neural signaling. CALCB Protein, Human (HEK293, mFc) is the recombinant human-derived CALCB protein, expressed by HEK293 , with C-mFc labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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