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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
human tPA
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "human tPA" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-P71051
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; Plasminogen Activator, Tissue Type; tPA; Tissue-Type Plasminogen Activator; Plasminogen Activator, Tissue; T-Plasminogen Activator; Plasminogen/Activator Kringle; Alteplase; Plasminogen Activator; Reteplase
Cat. No.: HY-108845
CAS No.: 191588-94-0
Synonyms: TNK-tPA
Target:
Research Areas:
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke .
Target:
Research Areas:
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .
Cat. No.: HY-114330
CAS No.: 2271122-53-1
Target:
Research Areas:
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .
Cat. No.: HY-P11413
CAS No.: 139446-70-1
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-19205A
CAS No.: 193739-23-0
Synonyms: LDP-392
Research Areas:
CMI-392 (LDP-392) is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis .
Cat. No.: HY-114015
CAS No.: 154628-42-9
Target:
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APC-6860 is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 is applicable to research related to breast cancer and prostate cancer .
Cat. No.: HY-19205B
CAS No.: 205654-37-1
Research Areas:
(2S,5S)-CMI-392 is the absolute configuration of CMI-392 (HY-19205A). CMI-392 is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis .
Cat. No.: HY-P73451
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; Plasminogen Activator, Tissue Type; tPA; Tissue-Type Plasminogen Activator; Plasminogen Activator, Tissue; T-Plasminogen Activator; Plasminogen/Activator Kringle; Alteplase; Plasminogen Activator; Reteplase
Cat. No.: HY-W794573
CAS No.: 149732-36-5
Target:
Research Areas:
APC-6860 hydrochloride is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 hydrochloride inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 hydrochloride is applicable to research related to breast cancer and prostate cancer .
Cat. No.: HY-N18117A
CAS No.: 1429747-10-3
Category:
Target:
Cat. No.: HY-165553
CAS No.: 873541-45-8
Target:
Research Areas:
ASB16165 is a selective and potent PDE7A inhibitor with an IC50 of 15 nM against human PDE7A. ASB16165 inhibits IL-12-induced IFN-γ production via a cAMP/PKA-dependent mechanism, reduces cutaneous TNF-α production, and suppresses keratinocyte proliferation. ASB16165 can be used in research on skin diseases such as psoriasis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
