873541-45-8
Chemical Structure
ASB16165
- CAS No.: 873541-45-8
- Formula:C23H29N5O2S
- Molecular Weight:439.58
IUPAC Name: 1-cyclohexyl-N-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
InChIKey: NFWMSIMJLJHZPQ-UHFFFAOYSA-N
SMILES: O=C(NC1=CN=C(C=C1)N2CCC(O)CC2)C=3SC4=C(C3)C(=NN4C5CCCCC5)C
Biological Activity: ASB16165 is a selective and potent PDE7A inhibitor with an IC50 of 15 nM against human PDE7A. ASB16165 inhibits IL-12-induced IFN-γ production via a cAMP/PKA-dependent mechanism, reduces cutaneous TNF-α production, and suppresses keratinocyte proliferation. ASB16165 can be used in research on skin diseases such as psoriasis[1][2][3].
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ASB16165 | ASB16165 is a selective and potent PDE7A inhibitor with an IC50 of 15 nM against human PDE7A. ASB16165 inhibits IL-12-induced IFN-γ production via a cAMP/PKA-dependent mechanism, reduces cutaneous TNF-α production, and suppresses keratinocyte proliferation. ASB16165 can be used in research on skin diseases such as psoriasis. | |||||||||||||||||||||
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- [1]. Kadoshima-Yamaoka K et al. ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. Immunol Lett. 2009 Feb 21;122(2):193-7. [Content Brief]
- [2]. Kadoshima-Yamaoka K et al. ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice. Eur J Pharmacol. 2009 Jun 24;613(1-3):163-6. [Content Brief]
- [3]. Goto M et al. Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo. Eur J Pharmacol. 2010 May 10;633(1-3):93-7. [Content Brief]
Keywords
