149732-36-5
Chemical Structure
APC-6860 (hydrochloride)
- CAS. Nr.: 149732-36-5
- Formula:C9H8ClIN2S
- Molecular Weight:338.60
IUPAC Name: 4-iodobenzo[b]thiophene-2-carboximidamide hydrochloride
InChIKey: LSGFKADNXDPWBF-UHFFFAOYSA-N
SMILES: IC1=CC=CC2=C1C=C(C(N)=N)S2.Cl
Biological Activity: APC-6860 hydrochloride is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 hydrochloride inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 hydrochloride is applicable to research related to breast cancer and prostate cancer[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
APC-6860 (hydrochloride) | APC-6860 hydrochloride is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 hydrochloride inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 hydrochloride is applicable to research related to breast cancer and prostate cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]
- [2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001;40(31):9125-9131. [Content Brief]
Keywords
