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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
integrin beta 7
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "integrin beta 7" in MCE Product Catalog:
6
6 Publications Verification
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Forschungsgebiete:
TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases .
6
6 Publications Verification
Synonyms: SB 683699
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Forschungsgebiete:
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity .
3
3 Cited Publications
Art. -Nr.: HY-P9911
CAS. Nr.: 943609-66-3
Synonyms: Anti-Human lymphocyte α4β7 integrin, Humanized Antibody; LDP-02; MLN-002
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3
3 Cited Publications
Art. -Nr.: HY-P9911A
CAS. Nr.: 943609-66-3
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2
2 Cited Publications
Art. -Nr.: HY-P9984
CAS. Nr.: 1044758-60-2
Synonyms: rhuMAb beta7; RG7413; PRO145223
1
1 Cited Publications
Art. -Nr.: HY-P990203
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Art. -Nr.: HY-177080
CAS. Nr.: 2417352-91-9
Synonyms: GS-1427
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Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease .
Synonyms: AJM300
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Forschungsgebiete:
Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice .
Art. -Nr.: HY-75385
CAS. Nr.: 455264-30-9
Synonyms: CDP323; UCB1184197
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Forschungsgebiete:
Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758 , is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders .
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RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity .
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BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins .
Synonyms: R-411 free base
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Forschungsgebiete:
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment .
Art. -Nr.: HY-P990207
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Art. -Nr.: HY-P99184
CAS. Nr.: 1342290-43-0
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Art. -Nr.: HY-177961
CAS. Nr.: 2417307-52-7
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Forschungsgebiete:
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of α4β7 integrin (integrin). Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC50) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease .
Art. -Nr.: HY-159179
CAS. Nr.: 863226-74-8
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α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model .
Art. -Nr.: HY-75385A
CAS. Nr.: 1214261-78-5
Synonyms: CDP323 sulfate; UCB1184197 sulfate
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Forschungsgebiete:
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758 , is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders .
Art. -Nr.: HY-185350
CAS. Nr.: 2640360-68-3
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Forschungsgebiete:
α4β7 Integrin-IN-2 is an inhibitor of human α4β7 integrin with an IC50 <5 nM. α4β7 Integrin-IN-2 modulates α4β7 integrin-mediated biological pathways. α4β7 Integrin-IN-2 can be used for the research of inflammatory dieases .
Art. -Nr.: HY-P705451
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: integrin alpha E beta 7; ITGAE&ITGB7
Art. -Nr.: HY-P705454
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: integrin alpha E beta 7; ITGAE&ITGB7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
