Anti-Mouse/Human Integrin β7 Antibody (FIB504)
Based on 1 Customer Validation
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma.
For research use only. We do not sell to patients.
- Purity : 99.70%
- Molecular Weight:142.01 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Human/Mouse
In Vivo
Anti-Mouse/Human Integrin β7 Antibody (FIB504) (100 μg/mL antibody pretreated MDSCs, i.v., single dose, on day 4 or day 7) does not significantly affect the survival period of C57BL/6 mice bearing GL261 or SB28 tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Imiquimod (HY-B0180) (2.5 mg) induced female MRL-lpr mice (5-8 weeks and 16 weeks)[1]
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Dosage:500 μg
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Administration:Intraperitoneal injection (i.p.), on day 7, 9 and 11
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Result:Significantly reduced the residence of renal ILC2s.
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Animal Model:25000 GL261 or 10000 SB28 cells injected C57BL/6 mice (4 weeks)[2]
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Dosage:100 μg/mL antibody pretreated MDSCs
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Administration:Intravenous injection (i.v.), single dose, on day 4 or day 7
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Result:Did not significantly alter the survival period of mice.
Increased the number of macrophages.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo blocking of integrin β7; Immunoprecipitation; Western blot; Flow cytometry
Verified Bioactivity
Chemical Information
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Appearance Liquid
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Molecular Weight 142.01 kDa
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Color Colorless to off-white
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SMILES
[Anti-Mouse/Human Integrin β7 Antibody (FIB504)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Ryu S, et al. The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis. Cell Mol Immunol. 2024 Jul;21(7):723-737. [Content Brief]
[2]. Bayik D, et al. Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets. Cancer Res. 2022 Nov 15;82(22):4274-4287. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse/Human Integrin β7 Antibody (FIB504) Related Classifications
HY-P990207 Related Classifications
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