Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)
Based on 1 publication(s) in Google Scholar
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis.
For research use only. We do not sell to patients.
- Purity : 99.08%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)
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Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
LPAM-1/Integrin α4β7
In Vitro
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (10 μg/mL, 10 mins) blocks the adhesion of FDCP-mix cells to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1)[1].
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (100 μg/mL, 72 h) suppresses the proliferation and cytokine secretion of CD8+ T cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CD8+ T cells
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Concentration:100 μg/mL
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Incubation Time:72 h
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Result:Suppressed CD8+ proliferation and cytokine IFN-γ secretion.
In Vivo
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (500 μg, i.p., daily from day 8 to 10) does not cause aberrant pregnancies in allogeneic BALB/c x C57BL/6J pregnancies[2].
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (i.p., a single dose) decreases Peyer’s patches and follicular B cells in C56B6 WT mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Allogeneic BALB/c x C57BL/6J pregnancies mice models[2]
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Dosage:500 μg
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Administration:Intraperitoneally injection, daily from day 8 to 10
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Result:Blocked recruitment of Mac-1+β7+ monocyte-like cells in vessels.
Showed significantly smaller uNK cells and increased numbers of uNK cells.
Showed histological abnormalities including hypocellularity of the decidua, apoorly organized metrial gland.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo Integrin α4β7 neutralization; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse LPAM-1/Integrin a4b7 Antibody (DATK32)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomater Res
Cell Membrane-Coated Nanotherapeutics for the Targeted Treatment of Acute and Chronic Colitis. [Abstract]2024 Nov 7:28:0102. PMID: 39512421
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Katayama Y, et al. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood. 2004 Oct 1;104(7):2020-6. [Content Brief]
[2]. Fernekorn U, et al. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol. 2004 Dec;34(12):3423-33. [Content Brief]
[3]. Su Z, Bian L, et al. Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes. Front Immunol. 2025 Jul 10;16:1623428. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Related Classifications
HY-P990203 Related Classifications
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