Itga4 - integrin alpha 4 Gene

Also Known as CD49D; Itga4B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16401

Summary

Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 Products (1)

mRNA Protein Name
NM_010576.4 NP_034706.3 integrin alpha-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IMP
IMP: Inferred from mutant phenotype
8145052 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell migration IMP
IMP: Inferred from mutant phenotype
23661644 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
16529735 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
12021259 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
12021259 MGI
acts upstream of or within chorio-allantoic fusion IMP
IMP: Inferred from mutant phenotype
7539359 MGI
acts upstream of or within face development IMP
IMP: Inferred from mutant phenotype
7539359 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7539359 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
8145052 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8562500 MGI
acts upstream of or within pericyte cell migration IMP
IMP: Inferred from mutant phenotype
16529735 MGI
acts upstream of or within vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
16529735 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23610556 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7539359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-4

  • CD49 antigen-like family member D

  • LPAM subunit alpha

  • VLA-4 receptor, alpha 4 subunit

  • VLA-4 subunit alpha

  • integrin alpha-IV

  • integrin alpha4B

  • lymphocyte Peyer patch adhesion molecules subunit alpha

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99184 Abrilumab 98.35% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06951 ITGA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17832 Itga4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24300 Itga4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga4 NCBI NCBI:3676