455264-30-9
455264-30-9
Chemical Structure
Zaurategrast ethyl ester
Synonym(s): CDP323; UCB1184197
- CAS No.: 455264-30-9
- Formula:C28H29BrN4O3
- Molecular Weight:549.46
IUPAC Name: ethyl (S)-3-(4-((2,7-naphthyridin-1-yl)amino)phenyl)-2-((2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino)propanoate
InChIKey: QCYAXXZCQKMTMO-QFIPXVFZSA-N
SMILES: O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O
Biological Activity: Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].
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Zaurategrast ethyl ester | 99.21% | Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders. | ||||||||||||||||||||
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References
- [1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. [Content Brief]
- [2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76. [Content Brief]
Keywords
