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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
interferon regulatory factor
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "interferon regulatory factor" in MCE Product Catalog:
4
4 Cited Publications
ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
2
2 Cited Publications
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YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .
1
1 Cited Publications
Cat. No.: HY-P70573A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: interferon regulatory factor 5; IRF-5; IRF5
1
1 Cited Publications
Cat. No.: HY-P82917
Synonyms: anti-interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody;
Cat. No.: HY-164278
CAS No.: 3035557-55-9
diABZI-V/C-Mal is a STING agonist (with a STING EC50 of 314 nM in TH1 dual reporter cells) and a Cathepsin B substrate. diABZI-V/C-Mal activates STING, thereby triggering the IRF3 signaling pathway. diABZI-V/C-Mal is cleaved by Cathepsin B to regenerate diABZI-NH2 .
Cat. No.: HY-176222
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IRF1 antagonist 1 (8003-3282) is a potent IRF1 (interferon regulatory factor) antagonist with anti-inflammatory activity. IRF1 antagonist 1 can maintain blood-brain barrier integrity and reduce brain edema. IRF1 antagonist 1 can improve neurological outcomes in an acute traumatic brain injury (TBI) mouse model .
Cat. No.: HY-174136
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STING Degrader-2 is an orally active STING degrader that promotes proteasome-independent degradation of STING. STING Degrader-2 inhibits cGAMP-induced STING activation, suppresses STING oligomerization, and inhibits phosphorylation of STING and interferon regulatory factor 3 (IRF3). STING Degrader-2 reduces serum IFN-β and CXCL-10 levels in a cGAMP-induced autoimmune disease mouse model. STING Degrader-2 can be used for the research of autoimmune diseases .
Cat. No.: HY-P2114
CAS No.: 173959-12-1
Cat. No.: HY-174308
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ZSA-215 is a potent and orally active STING agonist with an EC50 of 3.3 μM. ZSA-215 enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. ZSA-215 inhibits tumor regression and long-term survival of mice in MC38 colon cancer model. ZSA-215 can be used to the study of colon cancerr .
Cat. No.: HY-176256
endo-S-cGAFMP (Compound 3) is a STING agonist. endo-S-cGAFMP induces the production of interferon regulatory factors and proinflammatory cytokines by activating the cGAS-STING pathway, thereby enhancing innate and adaptive immune responses. endo-S-cGAFMP has potent immunostimulatory capacity in THP1 monocytes and RAW macrophages (EC50 values of 2.45 μM and 5.54 μM, respectively). endo-S-cGAFMP has significant antitumor activity. endo-S-cGAFMP can be used as a potential cancer immunotherapeutic agent, especially for studies of systemic administration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
