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IRF6 Antibody (YA2662)

(Synonyms: anti-Interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; Interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody; )
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Based on 1 publication(s) in Google Scholar

IRF6 Antibody (YA2662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF6.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for IRF6 Antibody (YA2662)
  • IRF6 Antibody (YA2662) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:500-1:1000 1:50-1:100 1:50-1:200

Product Details

Description

IRF6 Antibody (YA2662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF6.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 53 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 53 kDa
Species Reactivity Database

Entrez Gene: 3664 Human ;

SwissProt: O14896 Human ;

Immunogen

A synthesized peptide derived from human IRF6 aa404-467.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105009

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for IRF6 Antibody (YA2662)
    Western blot analysis of extracts from Jurkat(lane 2(20ug) and K562(lane 3(20ug) using IRF6 Antibody (HY-P82917) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    IRF6 is a Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription

  • Subcellular Localization

    Nucleus; Cytoplasm

  • Expression


    Tissue_specificity:Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas

  • Isoforms & Post-Translational Modification

    O14896 has 2 isomers: O14896-1: 53130 Da (predicted); O14896-2: 41930 Da (predicted).
    Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation

  • Subunit

    Interacts with SERPINB5

  • SwissProt ID

    O14896

  • Gene ID
    3664 [NCBI]
  • Synonyms

    anti-Interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; Interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody;

  • Research Field

    Immunology

IRF6 Antibody (YA2662) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Jurkat(lane 2(20ug) and K562(lane 3(20ug) using IRF6 Antibody (HY-P82917) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • IRF6 Antibody (YA2662) Product Image
    1/16
  • Experimental Validation Results for IRF6 Antibody (YA2662)
  • IRF6 Antibody (YA2662) Product Image
  • Experimental Validation Results for IRF6 Antibody (YA2662)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Jurkat(lane 2(20ug) and K562(lane 3(20ug) using IRF6 Antibody (HY-P82917) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for IRF6 Antibody (YA2662)
  • IRF6 Antibody (YA2662) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Jurkat(lane 2(20ug) and K562(lane 3(20ug) using IRF6 Antibody (HY-P82917) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • IRF6 Antibody (YA2662) Product Image WB