IRF2 Antibody (YA3130)

Art. -Nr.: HY-P83385: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

IRF2 Antibody (YA3130) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF2.

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Größe	Verfügbarkeit	Menge
20 μL	Auf Lager	Estimated Time of Arrival: December 31
50 μL	Auf Lager	Estimated Time of Arrival: December 31
100 μL	Auf Lager	Estimated Time of Arrival: December 31
250 μL	Angebot einholen

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IRF2 Antibody (YA3130) Spezialitätsempfehlungen:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

IRF2 Antibody (YA3130) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF2.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molekulargewicht

Predicted band size: 39 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P14316

Gene ID

3660 [NCBI]

Immunogen

A synthesized peptide derived from human IRF2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:20-1:50
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:500

Sensitivity	Endogenous	Reinheit	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:Expressed throughout the epithelium of the colon. Also expressed in lamina propria

Induction:By viruses and IFN

Isoforms & Post-Translational Modification：P14316 has 2 isomers: P14316-1: 39354 Da (predicted); P14316-2: 39156 Da (predicted).
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity;The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter

Subunit：Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity

Database

Entrez Gene: 3660 Human ; 16363 Mouse ;

SwissProt: P14316 Human ; P23906 Mouse ;

OMIM: 147576 Human

Research Field

Immunology

Synonyms

Interferon regulatory factor 2; IRF 2

Dokumentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/nci-h1975-cell.html [Content Brief]

IRF2 Antibody (YA3130) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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IRF2 Antibody (YA3130)

IRF2 Antibody (YA3130) Spezialitätsempfehlungen:

Product Detail

Background

Beschreibung

Verweise

IRF2 Antibody (YA3130) Related Classifications

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