IRF2 - interferon regulatory factor 2 Gene

Also Known as IRF-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3660

About IRF2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,387,729-184,474,550 (from NCBI)

This gene has 23 transcripts (splice variants), 231 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 28.3), lymph node (RPKM 28.2) and 25 other tissues.

Summary

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably Other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

IRF2 Products (1)

mRNA	Protein	Name
NM_002199.4	NP_002190.2	interferon regulatory factor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9540062	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9540062	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	9540062	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	9540062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9540062	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9540062	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9540062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF2 Protein Structure

IRF

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 2

IRF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRF2	P14316	PPP3CB	Homo sapiens	P16298	Anti Tag CoIP	21903422
Intra	IRF2	P14316	FOXK1	Homo sapiens	P85037	Anti Tag CoIP	33961781
Intra	IRF2	P14316	FOXK1	Homo sapiens	P85037	Anti Tag CoIP	28514442
Intra	IRF2	P14316	FOXK1	Homo sapiens	P85037	Anti Tag CoIP	21903422
Intra	IRF2	P14316	FOXK2	Homo sapiens	Q01167	Anti Tag CoIP	33961781
Intra	IRF2	P14316	FOXK2	Homo sapiens	Q01167	Anti Tag CoIP	28514442
Intra	IRF2	P14316	FOXK2	Homo sapiens	Q01167	Anti Tag CoIP	21903422
Intra	IRF2	P14316	TASOR2	Homo sapiens	Q5VWN6	Anti Tag CoIP	33961781
Intra	IRF2	P14316	TASOR2	Homo sapiens	Q5VWN6	Anti Tag CoIP	28514442
Intra	IRF2	P14316	ATG7	Homo sapiens	O95352	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83385	IRF2 Antibody (YA3130)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P83385A	IRF2 Antibody (YA3130)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Embryonal Testis Carcinoma	Testicular Embryonal Carcinoma Embryonal Carcinoma Of Testis Embryonal Carcinoma Of The Testis
Psoriasis
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06903	IRF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06904	IRF2BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06905	IRF2BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06906	IRF2BPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183519	AH057	Inhibitor	/	Unkown
HY-RS18947	Irf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25437	Irf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29522	Irf2bp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29523	Irf2bp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IRF2	VGNC	VGNC:73760
Mus musculus	IRF2	MGD	MGI:96591
Canis familiaris	IRF2	VGNC	VGNC:42092
Bos taurus	IRF2	VGNC	VGNC:30271
Felis catus	IRF2	VGNC	VGNC:67823
Rattus norvegicus	IRF2	RGD	RGD:1304922
Others	IRF2	NCBI