ATG7 - autophagy related 7 Gene

Also Known as GSA7; APG7L; SCAR31; APG7-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10533

About ATG7

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:11,272,397-11,576,353 (from NCBI)

This gene has 26 transcripts (splice variants), 199 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 10.0), thyroid (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes an E1-like activating enzyme that is essential for Autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, Mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

ATG7 Products (10)

mRNA	Protein	Name
NM_001136031.3	NP_001129503.2	ubiquitin-like modifier-activating enzyme ATG7 isoform b
NM_001144912.2	NP_001138384.1	ubiquitin-like modifier-activating enzyme ATG7 isoform c
NM_001349232.2	NP_001336161.1	ubiquitin-like modifier-activating enzyme ATG7 isoform a
NM_001349233.2	NP_001336162.1	ubiquitin-like modifier-activating enzyme ATG7 isoform a
NM_001349234.2	NP_001336163.1	ubiquitin-like modifier-activating enzyme ATG7 isoform a
NM_001349235.2	NP_001336164.1	ubiquitin-like modifier-activating enzyme ATG7 isoform a
NM_001349236.2	NP_001336165.1	ubiquitin-like modifier-activating enzyme ATG7 isoform d
NM_001349237.2	NP_001336166.1	ubiquitin-like modifier-activating enzyme ATG7 isoform e
NM_001349238.2	NP_001336167.1	ubiquitin-like modifier-activating enzyme ATG7 isoform f
NM_006395.3	NP_006386.1	ubiquitin-like modifier-activating enzyme ATG7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Atg12 activating enzyme activity	IDA IDA: Inferred from direct assay	37943659	GOA
enables Atg12 activating enzyme activity	IMP IMP: Inferred from mutant phenotype	22170151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11096062	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11096062	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	22170151	GOA
involved in autophagy	IGI IGI: Inferred from genetic interaction	28389568	GOA
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	25327288	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in cellular response to hyperoxia	IDA IDA: Inferred from direct assay	20543840	GOA
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	20543840	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	37943659	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23290079	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in mitophagy	IGI IGI: Inferred from genetic interaction	19279012	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	20543840	GOA
acts upstream of or within positive regulation of protein modification process	IDA IDA: Inferred from direct assay	12890687	GOA
acts upstream of or within protein lipidation	IDA IDA: Inferred from direct assay	12890687	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20543840	GOA
is active in phagophore assembly site	IDA IDA: Inferred from direct assay	37943659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG7 Protein Structure

ThiF

0
200
400
600
703 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like modifier-activating enzyme ATG7	APG7 autophagy 7-like

ATG7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATG7	O95352	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	18296641
Intra	ATG7	O95352	IRF2	Homo sapiens	P14316	Anti Tag CoIP	21903422
Intra	ATG7	O95352	EEF1D	Homo sapiens	P29692	Display Tech	20195357
Intra	ATG7	O95352	EEF1D	Homo sapiens	P29692	TAP	20195357
Intra	ATG7	O95352	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG7	O95352	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG7	O95352	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	20562859
Intra	ATG7	O95352	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	20562859
Intra	ATG7	O95352	GABARAPL2	Homo sapiens	P60520	BioID	34524948
Intra	ATG7	O95352	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG7	O95352	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	ATG7	O95352	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80559	ATG7 Antibody (YA598)	WB	Human, Mouse, Rat
HY-P80559A	ATG7 Antibody (YA598)(PBS only)	WB	Human, Mouse, Rat
HY-P86509	ATG7 Antibody (YA6201)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 31	SCAR31 Spinocerebellar Ataxia, Autosomal Recessive, 31
Fatty Liver Disease, Nonalcoholic 1	NAFLD1 Hepatic Steatosis Fatty Liver Disease, Nonalcoholic, Susceptibility To, 1 Non-Alcoholic Fatty Liver Disease 1 Fatty Liver Steatohepatitis
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Danon Disease	Pseudoglycogenosis Ii Antopol Disease Glycogen Storage Disease Iib Glycogen Storage Disease Type 2b Glycogen Storage Disease Type Iib Gsd2b Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency Vacuolar Cardiomyopathy And Myopathy X-Linked Vacuolar Cardiomyopathy And Myopathy, X-Linked Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly Gsd2b, Formerly Gsd Iib, Formerly Glycogen Storage Cardiomyopathy Glycogen Storage Disease Limited To The Heart Pseudoglycogenosis 2 X-Linked Vacuolar Cardiomyopathy And Myopathy Lysosomal Glycogen Storage Disease With Normal Acid Maltase Glycogen Storage Disease Due To Lamp-2 Deficiency Gsd Due To Lamp-2 Deficiency Glycogenosis Due To Lamp-2 Deficiency Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity DAND Gsd-Iib
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Vici Syndrome	Absent Corpus Callosum Cataract Immunodeficiency VICIS Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum Dionisi Vici Sabetta Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome Dionisi-Vici-Sabetta-Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0538	Xylitol	Activator	99.5%	Yes

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146130	ATG7-IN-2		99.32%	Unkown
HY-145371	ATG7-IN-1	Inhibitor	99.84%	Unkown
HY-146131	ATG7-IN-3		99.26%	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-184501	UE01		/	Unkown
HY-179052	Apoptosis inducer 50	Activator	/	Unkown
HY-N13352	Bufothionine	Activator	/	Unkown
HY-151914	Antitumor agent-82		/	Unkown
HY-173133	Antitumor agent-199	Activator	/	Unkown
HY-170594	Antitumor agent-192		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATG7	RGD	RGD:1304817
Mus musculus	ATG7	MGD	MGI:1921494
Bos taurus	ATG7	VGNC	VGNC:26261
Canis familiaris	ATG7	VGNC	VGNC:38227
Macaca mulatta	ATG7	VGNC	VGNC:70086
Felis catus	ATG7	VGNC	VGNC:60006
Others	ATG7	NCBI