country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P83385A

IRF2 Antibody (YA3130)(PBS only)

Name: IRF2 Antibody (YA3130)(PBS only)
Brand: MedChemExpress
SKU: HY-P83385A
Availability: PreOrder

(Synonyms: Interferon regulatory factor 2; IRF 2)

IRF2 Antibody (YA3130) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF2.

For research use only. We do not sell to patients.

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:500-1:1000	1:20-1:50	1:200-1:500

Description

IRF2 Antibody (YA3130) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF2.

Host Rabbit
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 39 kDa

Immunogen

A synthesized peptide derived from human IRF2

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

IRF2 is a Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation
Subcellular Localization

Nucleus
Expression

Tissue_specificity:Expressed throughout the epithelium of the colon. Also expressed in lamina propria

Induction:By viruses and IFN
Isoforms & Post-Translational Modification

P14316 has 2 isomers: P14316-1: 39354 Da (predicted); P14316-2: 39156 Da (predicted).
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity;The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter
Subunit

Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity
SwissProt ID

P14316
Gene ID

3660 [NCBI]
Synonyms

Interferon regulatory factor 2; IRF 2
Research Field

Immunology