FOXK1 - forkhead box K1 Gene

Homo sapiens

Also known as FOXK1L

Gene ID: 221937 | Gene type: protein coding

About FOXK1

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:4,682,295-4,771,442 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 42 paralogues. Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FOXK1 Products(1)

mRNA	Protein	Name
NM_001037165.2	NP_001032242.1	forkhead box protein K1

FOXK1 Protein Structure

FHA

Forkhead

0
200
400
600
733 a.a.

Protein Preferred Names

Protein Names

forkhead box protein K1

MNF

Related Diseases

Diseases

Alias

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05059	FOXK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FOXK1	RGD	RGD:1309643
Canis familiaris	FOXK1	VGNC	VGNC:40957
Mus musculus	FOXK1	MGD	MGI:1347488
Bos taurus	FOXK1	VGNC	VGNC:58377
Macaca mulatta	FOXK1	VGNC	VGNC:72558

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