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  4. Inhibitors and Substrates
  5. IT9302

IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-γ production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-κB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-β, associated with the effective induction of foxp3+ regulatory T cells.

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IT9302

IT9302 Chemical Structure

CAS No. : 173959-12-1

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Description

IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-γ production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-κB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-β, associated with the effective induction of foxp3+ regulatory T cells[1].

Molecular Weight

1127.38

Formula

C48H82N14O13S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn
Sequence Shortening

AYMTMKIRN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (88.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8870 mL 4.4351 mL 8.8701 mL
5 mM 0.1774 mL 0.8870 mL 1.7740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8870 mL 4.4351 mL 8.8701 mL 22.1753 mL
5 mM 0.1774 mL 0.8870 mL 1.7740 mL 4.4351 mL
10 mM 0.0887 mL 0.4435 mL 0.8870 mL 2.2175 mL
15 mM 0.0591 mL 0.2957 mL 0.5913 mL 1.4784 mL
20 mM 0.0444 mL 0.2218 mL 0.4435 mL 1.1088 mL
25 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8870 mL
30 mM 0.0296 mL 0.1478 mL 0.2957 mL 0.7392 mL
40 mM 0.0222 mL 0.1109 mL 0.2218 mL 0.5544 mL
50 mM 0.0177 mL 0.0887 mL 0.1774 mL 0.4435 mL
60 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3696 mL
80 mM 0.0111 mL 0.0554 mL 0.1109 mL 0.2772 mL
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IT9302 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IT9302173959-12-1IT 9302IT-9302OthersInhibitorinhibitorinhibit

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