Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
intestinal microsomes
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "intestinal microsomes" in MCE Product Catalog:
1
Research Areas:
Acetyl tributyl citrate (Tributyl O-acetylcitrate) is a pharmaceutical excipient and biodegradable hydrophobic plasticizer. Acetyl tributyl citrate can be used in cosmetics, food packaging, and as a flavoring substance for food .
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Research Areas:
16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
Cat. No.: HY-129344
CAS No.: 96224-26-9
Target:
Research Areas:
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor .
Cat. No.: HY-130238
CAS No.: 90780-54-4
Synonyms: (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE
Target:
Research Areas:
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Cat. No.: HY-130288
CAS No.: 90780-53-3
Synonyms: (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE
Target:
Research Areas:
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Cat. No.: HY-19771
CAS No.: 1819986-22-5
Synonyms: GSK294; amyloid P-IN-1
Target:
Research Areas:
GSK3039294 is an orally active pro-drug of Miridesap (HY-101861), a circulating serum amyloid P component depleter. GSK3039294 undergoes hydrolysis to form miridesap via a monoester intermediate. GSK3039294 can be used for the research of systemic amyloidosis .
Cat. No.: HY-130287
CAS No.: 90780-51-1
Synonyms: (±)16-HDoHE; 16-hydroxy Docosahexaenoic acid; (±)16-HDoHE
Target:
Research Areas:
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Cat. No.: HY-123666
CAS No.: 78991-74-9
Synonyms: Bay o 2752
Target:
Research Areas:
Bay-02752 (Bay o 2752) is a lipid-lowering agent. Bay-02752 inhibits acyl-CoA activity in liver microsomes (IC50 = 0.95 μg/mL). Bay-02752 inhibits intestinal cholesterol absorption in rats. Bay-02752 inhibits gallstone formation in hamsters .
Cat. No.: HY-162109
Target:
Research Areas:
Thrombin inhibitor 11 is an orally active, competitive and selective α-Thrombin inhibitor, with a Ki value of 65 nM against h-αThrombin and a Ki value of 10.3 nM against rat-derived α-thrombin. Thrombin inhibitor 11 can be used for the research of thrombotic diseases .
Cat. No.: HY-130046R
CAS No.: 547-81-9
Synonyms: 16-epi-Estriol (Standard); 16β,17β-Estriol (Standard)
Research Areas:
16-Epiestriol (Standard) is the analytical standard of 16-Epiestriol (HY-130046). This product is intended for research and analytical applications. 16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
Cat. No.: HY-183982
CAS No.: 2173066-81-2
Target:
Research Areas:
PAR4 antagonist 9-phosphoric acid is a phosphate prodrug of the PAR4 antagonist 9 (HY-183983). PAR4 antagonist 9-phosphoric acid is applicable to research related to arterial thrombosis .
Cat. No.: HY-115499A
CAS No.: 1310540-31-8
Target:
Research Areas:
MPC-0767 free base is an orally active prodrug of Hsp90 inhibitor. MPC-0767 free base undergoes rapid biotransformation to the parent Hsp90 inhibitor MPC-3100 via enzyme-mediated luminal cleavage. MPC-0767 free base is applicable to the research of refractory and recurrent cancers .
Cat. No.: HY-138198
CAS No.: 214265-97-1
Target:
Research Areas:
(E)-YIC-C8-434 is the E double-bond configuration of YIC-C8-434. YIC-C8-434 is an orally active ACAT inhibitor with anti-hypercholesterolemic activity .
Cat. No.: HY-156957
CAS No.: 300718-75-6
Target:
Research Areas:
5-CNAC disodium is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC disodium can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin (HY-P0090)) when administered together with it in the gastrointestinal tract. 5-CNAC disodium binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC disodium can be used in the research of adjuvants for orally administered peptide agents .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
