78991-74-9
78991-74-9
Chemical Structure
Bay-02752
Synonym(s): Bay o 2752
- CAS No.: 78991-74-9
- Formula:C31H44N4O2
- Molecular Weight:504.71
IUPAC Name: N,N'-(undecane-1,11-diyl)bis(2-methylindoline-1-carboxamide)
InChIKey: GOJXYVFOLUSEAA-UHFFFAOYSA-N
SMILES: O=C(N1C(C)CC2=C1C=CC=C2)NCCCCCCCCCCCNC(N3C(C)CC4=C3C=CC=C4)=O
Biological Activity: Bay-02752 (Bay o 2752) is a lipid-lowering agent. Bay-02752 inhibits acyl-CoA activity in liver microsomes (IC50 = 0.95 μg/mL). Bay-02752 inhibits intestinal cholesterol absorption in rats. Bay-02752 inhibits gallstone formation in hamsters[1][2].
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Bay-02752 | Bay-02752 (Bay o 2752) is a lipid-lowering agent. Bay-02752 inhibits acyl-CoA activity in liver microsomes (IC50 = 0.95 μg/mL). Bay-02752 inhibits intestinal cholesterol absorption in rats. Bay-02752 inhibits gallstone formation in hamsters. | |||||||||||||||||||||
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References
- [1]. AKritchevsky D, et al. Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters. Pharmacol Res Commun. 1987 Oct;19(10):679-84. [Content Brief]
- [2]. Harnett KM, et al.. Effects of Bay o 2752, a hypocholesterolemic agent, on intestinal taurocholate absorption and cholesterol esterification. J Pharmacol Exp Ther. 1989 Nov;251(2):502-9. [Content Brief]
Keywords
