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Cat. No.: HY-183982

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PAR4 antagonist 9-phosphoric acid

PAR4 antagonist 9-phosphoric acid is a phosphate prodrug of the PAR4 antagonist 9 (HY-183983). PAR4 antagonist 9-phosphoric acid is applicable to research related to arterial thrombosis.

For research use only. We do not sell to patients.

CAS No.: 2173066-81-2
Formula: C₂₉H₃₀FN₆O₈PS
Molecular Weight:672.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAR4 antagonist 9-phosphoric acid Chemical Structure

CAS No.: 2173066-81-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

PAR4 antagonist 9-phosphoric acid is a phosphate prodrug of the PAR4 antagonist 9 (HY-183983). PAR4 antagonist 9-phosphoric acid is applicable to research related to arterial thrombosis^[1].

Parmacokinetics

Species	Dose	Route	AUC_last	F
Rat^[1]	2 mg/kg	p.o.	2900 nM·h	21.3 %

In Vivo

PAR4 antagonist 9-phosphoric acid (compound 44) (p.o.) is administered to healthy rats and generates parent compound 32 in vivo, with a relative bioavailability of 44% compared with the optimized formulation of the parent compound^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2173066-81-2
Molecular Weight 672.62
Formula C₂₉H₃₀FN₆O₈PS
SMILES

O=C(O[C@@H]([C@@H](OC1=C(F)C=C2N=C(C3=C4N=CC(OCC)=NC4=CC(C)=C3)SC2=C1)C)C)NC5=CN=C(CCOP(O)(O)=O)N=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Halpern OS, et al. Solubility-Driven Lead Optimization of PAR4 Antagonists and Evaluation of a Phosphate Ester Prodrug Delivery Strategy. ACS Med Chem Lett. 2026 May 11.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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