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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
membrane protein stabilization
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "membrane protein stabilization" in MCE Product Catalog:
4
4 Cited Publications
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Research Areas:
CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins .
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4 Cited Publications
2
Cat. No.: HY-W012669
CAS No.: 643-79-8
Synonyms: Phthaldialdehyde
Cat. No.: HY-W250195
CAS No.: 5157-04-0
Synonyms: (R)-VX-445
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(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .
Cat. No.: HY-P10626
Synonyms: NSPr
Cat. No.: HY-N1989
CAS No.: 11028-00-5
Cat. No.: HY-W250172
CAS No.: 92046-34-9
Cat. No.: HY-W250176
CAS No.: 60828-78-6
Cat. No.: HY-W099581R
CAS No.: 14933-09-6
Synonyms: SB3-14 (Standard); DMAPS (Standard)
Cat. No.: HY-W250199
CAS No.: 27252-75-1
Synonyms: n-Octyl-oligo-oxyethylene
Cat. No.: HY-W250171
CAS No.: 5698-39-5
Synonyms: Polyoxyethylene (10) cetyl ether
Cat. No.: HY-15435R
CAS No.: 75621-03-3
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CHAPS (Standard) is the analytical standard of CHAPS. This product is intended for research and analytical applications. CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution .
Cat. No.: HY-158204
CAS No.: 1019110-87-2
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
CNB-001 is a potent and orally active 5-lipoxygenase (5-LOX) inhibitor. CNB-001 can decreases 5-LOX expression and increase proteasome activity. CNB-001 can inhibit accumulation of soluble Amyloid-β and ubiquitinated aggregated proteins. CNB-001 can inhibit apoptosis, ROS production and stabilize mitochondrial membrane potential. CNB-001 can reduce insulin resistance and increase glucose uptake. CNB-001 also exhibits anti-ischemic, anti-inflammatory effects. CNB-001 can be used for the researches of inflammation, neurological and metabolic disease, such as Alzheimer's disease, stroke and diabetes .
Cat. No.: HY-126476
CAS No.: 79162-16-6
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Cat. No.: HY-160281
CAS No.: 2271351-19-8
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CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies .
Cat. No.: HY-W250178
CAS No.: 24233-81-6
Cat. No.: HY-W250179
CAS No.: 5168-91-2
Synonyms: Polyoxyethylene (6) cetyl ether
Cat. No.: HY-158884
CAS No.: 2121543-66-4
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CALXCHOL sodium is a calixarene detergent that can be used to solubilize and stabilize membrane proteins.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
