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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
mitochondrial ATP synthase
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "mitochondrial ATP synthase" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-17355A
CAS No.: 104632-27-1
Synonyms: (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride
Target:
ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .
2
2 Cited Publications
Cat. No.: HY-17355B
CAS No.: 104632-28-2
Synonyms: (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704
Target:
PINK1/Parkin Glutathione Peroxidase Sodium Channel ATP Synthase NOD-like Receptor (NLR) Mitophagy Ferroptosis Autophagy Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .
Cat. No.: HY-N6784
CAS No.: 11050-94-5
Target:
Target:
Research Areas:
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .
Cat. No.: HY-N12486
Target:
Cat. No.: HY-125637
CAS No.: 33538-72-6
Synonyms: Aabomycin A2
Target:
Research Areas:
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .
Cat. No.: HY-17355BS
CAS No.: 1432230-09-5
Synonyms: (R)-Pramipexole-d3 dihydrochloride; R-(+)-Pramipexole-d3 dihydrochloride; KNS-760704-d3 dihydrochloride
Cat. No.: HY-175412
CAS No.: 142473-18-5
Synonyms: Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane); H12-TAC
Target:
Research Areas:
DDTAC (H12-TAC) is a detergent that can extract and solubilize membrane proteins. DDTAC has a thio dodecanoyl chain linked to a polar group made of Tris polyalcoholic moieties and can be utilized in extracting yeast ATP synthase from mitochondrial membranes .
Cat. No.: HY-172959
CAS No.: 554414-59-4
Target:
Research Areas:
mPTP-IN-1 (Compound 14e) is a mitochondrial permeability transition pore (mPTP) inhibitor. mPTP-IN-1 blocks calcium-induced mPTP opening by targeting the C subunit of ATP synthase. mPTP-IN-1 can be used to study myocardial ischemia/reperfusion injury (IRI) .
Cat. No.: HY-N12486A
CAS No.: 2962060-53-1
Target:
Cat. No.: HY-17355AR
CAS No.: 104632-27-1
Synonyms: (R)-Pramipexole dihydrochloride (Standard); R-(+)-Pramipexole dihydrochloride (Standard); KNS-760704 dihydrochloride (Standard)
Target:
Reference Standards ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.
Cat. No.: HY-L089
1,169 compounds
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.
MCE supplies a unique collection of 1,169 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.
Cat. No.: HY-P72098
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5F1D; F-ATPase Delta Subunit; Prev. ATP5D; ATP synthase Subunit Delta, mitochondrial; ATP synthase F(1) Complex Subunit Delta, mitochondrial; mitochondrial ATP synthase, Delta Subunit; ATP synthase, H+ Transporting, mitochondrial F1 Complex, Delta Subu
Cat. No.: HY-P72097
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5F1D; F-ATPase Delta Subunit; Prev. ATP5D; ATP synthase Subunit Delta, mitochondrial; ATP synthase F(1) Complex Subunit Delta, mitochondrial; mitochondrial ATP synthase, Delta Subunit; ATP synthase, H+ Transporting, mitochondrial F1 Complex, Delta Subu
Cat. No.: HY-P71550
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5MG; ATP synthase, H+ Transporting, mitochondrial Fo Complex, Subunit G; Prev. ATP5L; F1Fo-ATP synthase Complex Fo Membrane Domain G Subunit; ATP5JG; ATP synthase Subunit G, mitochondrial; ATP synthase, H+ Transporting, mitochondrial F0 Complex, Subuni
Cat. No.: HY-P702220
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5MF; ATP synthase F Chain, mitochondrial; Prev. ATP5J2; ATP synthase, H+ Transporting, mitochondrial F0 Complex, Subunit F, Isoform 2; ATP5JL; ATP synthase, H+ Transporting, mitochondrial F0 Complex, Subunit F2; ATP synthase F(0) Complex Subunit F, Mit
Species:
Source:
Cat. No.: HY-P86778
Synonyms: ATP synthase F(0) complex subunit B1, mitochondrial Curated ATP synthase peripheral stalk-membrane subunit b Curated ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b (ATPase subunit b) ATP5PB ATP5F1
Cat. No.: HY-P72095
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5F1A; ATP synthase, H+ Transporting, mitochondrial F1 Complex, Alpha Subunit, Isoform 1, Cardiac Muscle; Prev. ATP5AL2; mitochondrial ATP Synthetase, Oligomycin-Resistant; Prev. ATP5A1; ATP synthase Alpha Chain, mitochondrial; Prev. ATPM; ATP Sythase (
Cat. No.: HY-P72096
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5F1A; ATP synthase, H+ Transporting, mitochondrial F1 Complex, Alpha Subunit, Isoform 1, Cardiac Muscle; Prev. ATP5AL2; mitochondrial ATP Synthetase, Oligomycin-Resistant; Prev. ATP5A1; ATP synthase Alpha Chain, mitochondrial; Prev. ATPM; ATP Sythase (
Cat. No.: HY-P71716
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5F1B; ATP synthase Subunit Beta, mitochondrial; Prev. ATP5B; Epididymis Secretory Protein Li 271; Prev. ATPSB; ATP synthase Subunit Beta; ATP synthase, H+ Transporting, mitochondrial F1 Complex, Beta Polypeptide; HEL-S-271; ATP synthase F(1) Complex Su
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
