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Results for "

oligonucleotide labeling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (4) Biochemical Assay Reagents (14) DNA Stain (9) DNA/RNA Synthesis (8) Dystrophin (1) Fluorescent Dye (101) HIV (1) Huntingtin (1) Isotope-Labeled Compounds (8) Liposome (1) MicroRNA (1) Nucleoside Antimetabolite/Analog (2) Phosphoramidites (5) Reverse Transcriptase (1) SOD (1) STAT (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)
Click Chemistry:	Labeling and Fluorescence Imaging (6) DBCO (3) Azide (7) Alkynes (3)
Oligonucleotides:	MicroRNAs (1) CpG ODNs (2) miRNA inhibitors (1) Antisense Oligonucleotides (4) Uracil (5) Phosphoramidites (5)

143

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Antibody-Oligonucleotide Conjugates (AOCs)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0819

CY5-SE Maximum Cited Publications 37 Publications Verification Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-66021

6-FAM 2 Publications Verification 6-Carboxyfluorescein	Fluorescent Dye	Others
6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids.

HY-D0819A

CY5-SE triethylamine salt Maximum Cited Publications 37 Publications Verification Cy5 NHS Ester triethylamine salt; Sulfo-Cyanine5 Succinimidyl Ester triethylamine salt	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) triethylamine salt is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Cy5-SE triethylamine salt is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides Ex=649 nm; Em=670 nm) .

HY-135414

Cyanine5 NHS ester chloride 1 Publications Verification	Fluorescent Dye	Others
Cyanine5 NHS ester chloride is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides .

HY-D2096

Alexa fluor 647 NHS ester 1 Publications Verification	Fluorescent Dye	Others
Alexa fluor 647 NHS ester can be used to label Alexa fluor 647 to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-131326

DOTA-tris(tBu)ester NHS ester	Biochemical Assay Reagents	Cancer
DOTA-tris(tBu)ester NHS ester is a bifunctional precursor to a DOTA-based chelating agent. DOTA-tris(tBu)ester NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, and upon deprotection forms stable complexes with metal ions for applications in molecular imaging .

HY-D0049

6-TAMRA-SE 1 Publications Verification 6-TAMRA-NHS ester; 6-Carboxytetramethylrhodamine N-succinimidyl ester	DNA Stain	Others
6-TAMRA-SE (6-TAMRA-NHS ester) is a fluorescent dye carrying the amine reactive group. 6-TAMRA-SE is one of the traditional fluorophores used for automated DNA sequencing .

HY-155500

Digoxigenin NHS ester	Fluorescent Dye	Others
Digoxigenin NHS ester is an activated ester which readily reacts with amino groups under mild conditions, attaching the Digoxigenin (HY-B1025) moiety to proteins or amino-. Digoxigenin NHS ester can be used to label proteins and oligonucleotides .

HY-D0913

1-Methyl-7-nitroisatoic anhydride 3 Publications Verification 1M7	Fluorescent Dye	Others
1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity, can be used for RNA structure analysis .

HY-D0723

5(6)-TAMRA SE 3 Publications Verification 5(6)-Carboxytetramethylrhodamine N-succinimidyl ester	Fluorescent Dye	Cancer
5(6)-TAMRA SE is a fluorescent dye that emits red fluorescence. 5(6)-TAMRA SE binds to oligonucleotides and is used in DNA sequencing. 5(6)-TAMRA SE can be used in cancer research (Ex/Em = 565/580 nm) .

HY-D2096A

Alexa fluor 647 NHS ester TEA 1 Publications Verification	Fluorescent Dye	Others
Alexa fluor 647 NHS ester TEA can be used to label Alexa fluor 647 to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-W040289

Mal-amido-PEG2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-D2171A

AF488 DBCO ditriethylamine 1 Publications Verification	Fluorescent Dye	Others
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-15939

6-FAM SE	Fluorescent Dye	Metabolic Disease
6-FAM SE (6-carboxyfluorescein succinimidyl ester) is a fluorescent labeling reagent. 6-FAM SE is used for oligonucleotide labeling and DNA sequencing .

HY-D0784

5-ROX 1 Publications Verification 5-Carboxy-X-rhodamine	Fluorescent Dye	Others
5-ROX (5-Carboxy-X-rhodamine), a rhodamine dye, exhibits strong fluorescence property in aqueous buffer with the λ_exit of 580 nm (ε=3.6×10 ⁴ M ^-1 cm ^-1), and λ_emit of 604 nm (=0.94) .

HY-D0043

5(6)-ROX 1 Publications Verification 5(6)-Carboxy-X-rhodamine	DNA Stain	Others
5(6)-ROX (5(6)-Carboxy-X-rhodamine) is a nucleic acid fluorescent label which can be used as a reference dye for real-time polymerase chain reaction (Em/Ex = 605/585 nm) .

HY-D0053

6-ROX 6-Carboxy-X-rhodamine	Fluorescent Dye	Others
6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 .

HY-D1668

Biotin-11-dCTP	DNA Stain Reverse Transcriptase	Infection Neurological Disease Cancer
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important *DNA labeling* reagent*. In random primer DNA labeling* reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-D2746

Cy5.5 bis-NHS ester	Fluorescent Dye	Others
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-D1085

AMCA-X SE	Fluorescent Dye	Others
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-D2328

Alexa Fluor 680 NHS ester Alexa Fluor 680 succinimidyl ester	Fluorescent Dye	Others
Alexa Fluor 680 NHS ester (Alexa Fluor 680 succinimidyl ester) is a near-infrared (NIR) fluorescent dye. NHS esters can be used to label to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 679/702 nm) .

HY-D0967

Cy5-bifunctional dye	Fluorescent Dye	Others
Cy5-bifunctional dye is a bifunctional dye used for covalent labeling of primary amines on proteins or oligonucleotides (Ex/Em = 649 nm/670 nm). Cy5-bifunctional dye can label recombinant annexin-V to assess phosphatidylserine exposure on the cell surface via flow cytometry. Cy5-bifunctional dye can label anti-human IgG (H + L) secondary antibodies. Cy5-bifunctional dye is applicable to studies of glanders and melioidosis .

HY-D1070

DBCO-PEG4-TAMRA	DNA Stain	Others
DBCO-PEG4-TAMRA is a PEG-based TAMRA dye and contains a DBCO group, which enables Click Chemistry. The TAMRA dye is a dye widely used in oligonucleotide labeling and automated DNA sequencing applications. DBCO-PEG4-TAMRA is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-126509

Mal-amido-PEG10-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-D2171

AF488 DBCO	Fluorescent Dye	Others
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-DY1063

CY5-SE (solution)	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) (solution) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm) :649, Emission (nm) : 670. Solvent and concentration: DMSO: 10 mM

HY-D1899

VIC phosphoramidite, 6-isomer	Fluorescent Dye	Others
VIC phosphoramidite, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .

HY-D2175

AF 555 NHS ester	Fluorescent Dye	Others
AF 555 NHS ester is a bright, orange-red fluorescence probe. AF 555 NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 552/566 nm) .

HY-D2170

AF488 streptavidin	Fluorescent Dye	Others
AF488 streptavidin is a fluorescently labeled streptavidin. AF488 streptavidin is a streptavidin conjugated to Alexa Fluor 488, with 4 fluorophores per protein molecule, enabling stoichiometric fluorescent labeling of cell surface targets. AF488 streptavidin can form a complex with biotinylated E07 aptamer to stain cells expressing EGFR, and the staining is reversible after treatment with mA9 detoxifying oligonucleotides (Ex/Em = 470/520 nm) .

HY-D0818

CY3-YNE Sulfo-Cyanine3-alkyne	Fluorescent Dye	Others
CY3-YNE (Sulfo-Cyanine3-alkyne) is a dye for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. CY3-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1790

Vari Fluor 640 SE VF 640 SE	Fluorescent Dye	Others
Vari Fluor 640 SE (VF 640 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=648 nm/664 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D1086

6-Carboxy-X-rhodamine, succinimidyl ester 6-ROX, SE	DNA Stain	Others
6-Carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) is a fluorescent dye for oligonucleotide labeling and automated DNA sequencing .

HY-D2245

Cy5.5 phosphoramidite	Fluorescent Dye	Others
Cy5.5 phosphoramidite, a cyanine derivative, is a fluorescent labeling reagent for preparing fluorescence-labeled oligonucleotides .

HY-135414B

Cyanine5 NHS ester iodide 1 Publications Verification	Fluorescent Dye	Others
Cyanine5 NHS ester iodide is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides .

HY-D1221

6-Fluorescein phosphoramidite	Fluorescent Dye	Others
6-Fluorescein phosphoramidite is a potent fluorescent dye. 6-Fluorescein phosphoramidite can be used to label oligonucleotides .

HY-W190937

PC Azido-PEG3-NHS carbonate ester	Biochemical Assay Reagents	Others
PC Azido-PEG3-NHS carbonate ester is a photocleavable linker. It can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-D1692

BODIPY 650/665 NHS ester	Fluorescent Dye	Others
BODIPY 650/665 NHS ester is bright, far-red fluorescent dye that can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules . Ex / Em = 646 / 660 nm

HY-D2328A

Alexa Fluor 680 NHS ester diTEA Alexa Fluor 680 succinimidyl ester diTEA	Fluorescent Dye	Others
Alexa Fluor 680 NHS ester (Alexa Fluor 680 succinimidyl ester) diTEA is a near-infrared (NIR) fluorescent dye. NHS esters can be used to label to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 679/702 nm) .

HY-D1791

Vari Fluor 750 SE VF 750 SE	Fluorescent Dye	Others
Vari Fluor 750 SE (VF 750 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=747 nm/770 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D2244

Cy3 phosphoramidite	Fluorescent Dye	Others
Cy3 phosphoramidite?is a fluorescent dye for oligonucleotide labeling.

HY-D2502

Cy7 hydrazide	Fluorescent Dye	Others
Cy7 hydrazide is a Cy7 (HY-D0825) dye derivative with hydrazine functionality. The hydrazide group of Cy7 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds .

HY-D1409

DMTr-4'-F-U-CED-TBDMS phosphoramidite DMTr-4'-F-uridine-CED-TBDMS phosphoramidite	DNA Stain Phosphoramidites	Cardiovascular Disease
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-D1089

6-JOE, SE	Fluorescent Dye	Others
6-JOE, SE is an amine-reactive fluorescent probe and is suitable for postsynthetic labeling of amino-modified oligonucleotides .

HY-D1596A

Cyanine 3.5 bromide Cy3.5 NHS ester bromide; Cy 3.5 bromide	Fluorescent Dye	Others
Cyanine 3.5 bromide (Cy3.5 NHS ester bromide) is an analog of the Cy3.5 fluorophore. Cyanine 3.5 bromide is a red reactive fluorescent dye. Cyanine 3.5 bromide is used to label amino groups in peptides, proteins, and oligonucleotides. (λ_ex=591 nm, λ_em=604 nm) .

HY-D1410

DMTr-4'-F-5-Me-U-CED phosphoramidite DMTr-4'-F-5-Methyluridine-CED phosphoramidite	Fluorescent Dye Phosphoramidites	Others
DMTr-4'-F-5-Me-U-CED phosphoramidite (DMTr-4'-F-5-Methyluridine-CED phosphoramidite), a dye reagent for oligonucleotide labeling, acts as efficient as the incorporation of native deoxyribonucleoside phosphoramidites. DMTr-4'-F-5-Me-U-CED phosphoramidite is a building block .

HY-157221

Biotin-16-dGTP tetralithium	Nucleoside Antimetabolite/Analog	Others
Biotin-16-dGTP tetralithium is a Biotin labeled dGTP, and can be used to label oligonucleotides .

HY-D1408

DMTr-4'-Me-U-CED-TBDMS phosphoramidite DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite	DNA Stain Phosphoramidites	Cardiovascular Disease
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-D1900

VIC azide, 6-isomer	Fluorescent Dye	Others
VIC azide, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .

HY-126507

Mal-amido-PEG1-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG1-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules

HY-D1596

Cyanine 3.5 chloride Cy3.5 NHS ester chloride; Cy 3.5 chloride	Fluorescent Dye	Others
Cyanine 3.5 (Cy3.5 NHS ester) chloride is an analog of Cy3.5 fluorophore. Cyanine 3.5 chloride is a reactive, red fluorescent dye. Cyanine 3.5 chloride is used for labeling of amino-groups in peptides, proteins, and oligonucleotides. (λ_ex=591 nm, λ_em=604 nm) .

Cat. No.	Product Name	Type

HY-D0819

CY5-SE

Maximum Cited Publications

37 Publications Verification

Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester

Fluorescent Dyes

Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-66021

6-FAM 2 Publications Verification 6-Carboxyfluorescein	Fluorescent Dyes
6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids.

HY-D0819A

CY5-SE triethylamine salt Maximum Cited Publications 37 Publications Verification Cy5 NHS Ester triethylamine salt; Sulfo-Cyanine5 Succinimidyl Ester triethylamine salt	Fluorescent Dyes
Cy5-SE (Cy5 NHS Ester) triethylamine salt is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Cy5-SE triethylamine salt is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides Ex=649 nm; Em=670 nm) .

HY-135414

Cyanine5 NHS ester chloride 1 Publications Verification	Fluorescent Dyes
Cyanine5 NHS ester chloride is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides .

HY-D2096

Alexa fluor 647 NHS ester 1 Publications Verification	Fluorescent Dyes
Alexa fluor 647 NHS ester can be used to label Alexa fluor 647 to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-D0049

6-TAMRA-SE 1 Publications Verification 6-TAMRA-NHS ester; 6-Carboxytetramethylrhodamine N-succinimidyl ester	Fluorescent Dyes
6-TAMRA-SE (6-TAMRA-NHS ester) is a fluorescent dye carrying the amine reactive group. 6-TAMRA-SE is one of the traditional fluorophores used for automated DNA sequencing .

HY-D1314

FAM azide, 6-isomer

6-FAM azide

Fluorescent Dyes

FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-D2906

Alexa fluor 647 maleimide

Fluorescent Dyes

Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics .

HY-D0913

1-Methyl-7-nitroisatoic anhydride 3 Publications Verification 1M7	Fluorescent Dyes
1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity, can be used for RNA structure analysis .

HY-D0723

5(6)-TAMRA SE 3 Publications Verification 5(6)-Carboxytetramethylrhodamine N-succinimidyl ester	Fluorescent Dyes
5(6)-TAMRA SE is a fluorescent dye that emits red fluorescence. 5(6)-TAMRA SE binds to oligonucleotides and is used in DNA sequencing. 5(6)-TAMRA SE can be used in cancer research (Ex/Em = 565/580 nm) .

HY-D2171A

AF488 DBCO ditriethylamine 1 Publications Verification	Fluorescent Dyes
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-15939

6-FAM SE	Fluorescent Dyes
6-FAM SE (6-carboxyfluorescein succinimidyl ester) is a fluorescent labeling reagent. 6-FAM SE is used for oligonucleotide labeling and DNA sequencing .

HY-D0784

5-ROX 1 Publications Verification 5-Carboxy-X-rhodamine	Fluorescent Dyes
5-ROX (5-Carboxy-X-rhodamine), a rhodamine dye, exhibits strong fluorescence property in aqueous buffer with the λ_exit of 580 nm (ε=3.6×10 ⁴ M ^-1 cm ^-1), and λ_emit of 604 nm (=0.94) .

HY-D0043

5(6)-ROX 1 Publications Verification 5(6)-Carboxy-X-rhodamine	Fluorescent Dyes
5(6)-ROX (5(6)-Carboxy-X-rhodamine) is a nucleic acid fluorescent label which can be used as a reference dye for real-time polymerase chain reaction (Em/Ex = 605/585 nm) .

HY-D0053

6-ROX 6-Carboxy-X-rhodamine	Fluorescent Dyes
6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 .

HY-D1668

Biotin-11-dCTP

Fluorescent Dyes

Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-D2365

QSY 21 NHS

Fluorescent Dyes

QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH₂) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence .

HY-D2746

Cy5.5 bis-NHS ester	Fluorescent Dyes
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-D1085

AMCA-X SE	Fluorescent Dyes
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-D2328

Alexa Fluor 680 NHS ester Alexa Fluor 680 succinimidyl ester	Fluorescent Dyes
Alexa Fluor 680 NHS ester (Alexa Fluor 680 succinimidyl ester) is a near-infrared (NIR) fluorescent dye. NHS esters can be used to label to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 679/702 nm) .

HY-D0967

Cy5-bifunctional dye

Fluorescent Dyes

Cy5-bifunctional dye is a bifunctional dye used for covalent labeling of primary amines on proteins or oligonucleotides (Ex/Em = 649 nm/670 nm). Cy5-bifunctional dye can label recombinant annexin-V to assess phosphatidylserine exposure on the cell surface via flow cytometry. Cy5-bifunctional dye can label anti-human IgG (H + L) secondary antibodies. Cy5-bifunctional dye is applicable to studies of glanders and melioidosis .

HY-D1801

Vari Fluor 488 SE VF 488 SE	Fluorescent Dyes
Vari Fluor 488 SE (VF 488 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=488 nm/513 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D1800

Vari Fluor 680 SE VF 680 SE	Fluorescent Dyes
Vari Fluor 680 SE (VF 680 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=680 nm/700 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D1090

JOE

Fluorescent Dyes

JOE is a xanthene fluorophore (i.e., 4′,5′-dichloro-2′,7′-dimethoxy-5 (6)-carboxyfluorescein; 2',7'-dimethoxy-4',5'-dichloro-6-carboxyfluorescein) with an absorption wavelength of approximately 525 nm and an emission wavelength of approximately 550 nm. The fluorescence quantum yield of JOE correlates with the rigidity of the linker arm and the distance to dG nucleoside. JOE is commonly used as a fluorescent label for oligonucleotides and molecular beacon probes, and also serves as the acceptor fluorophore in fluorescence energy transfer primers for DNA sequencing .

HY-D2171

AF488 DBCO	Fluorescent Dyes
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-D0820

CY5-YNE Sulfo-Cyanine5-alkyne	Fluorescent Dyes
CY5-YNE (Sulfo-Cyanine5-alkyne) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides (Ex: 650 nM; Em: 680 nm). CY5-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135835

6-FAM-PEG3-Azide

Fluorescent Dyes

6-FAM-PEG3-Azide is a fluorescent dye that can be used to label oligonucleotide . 6-FAM-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-42984

BHQ-2 NHS

Fluorescent Dyes

BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-151711

Sulfo-Cy5.5 Azide

Fluorescent Dyes

Sulfo-Cy5.5 Azide is a click chemistry reagent containing an azide group. Sulfo-Cy5.5 Azide is also a water-soluble dye (Ex=673 nm, Em=707 nm), which designed to label sensitive molecules such as peptides, proteins and oligonucleotides. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-DY1063

CY5-SE (solution)

Fluorescent Dyes

Cy5-SE (Cy5 NHS Ester) (solution) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm) :649, Emission (nm) : 670.
Solvent and concentration: DMSO: 10 mM

HY-D1899

VIC phosphoramidite, 6-isomer	Fluorescent Dyes
VIC phosphoramidite, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .

HY-D2175

AF 555 NHS ester	Fluorescent Dyes
AF 555 NHS ester is a bright, orange-red fluorescence probe. AF 555 NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 552/566 nm) .

HY-D2170

AF488 streptavidin

Fluorescent Dyes

AF488 streptavidin is a fluorescently labeled streptavidin. AF488 streptavidin is a streptavidin conjugated to Alexa Fluor 488, with 4 fluorophores per protein molecule, enabling stoichiometric fluorescent labeling of cell surface targets. AF488 streptavidin can form a complex with biotinylated E07 aptamer to stain cells expressing EGFR, and the staining is reversible after treatment with mA9 detoxifying oligonucleotides (Ex/Em = 470/520 nm) .

HY-D0818

CY3-YNE Sulfo-Cyanine3-alkyne	Fluorescent Dyes
CY3-YNE (Sulfo-Cyanine3-alkyne) is a dye for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. CY3-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1802

Vari Fluor 425 SE VF 425 SE	Fluorescent Dyes
Vari Fluor 425 SE (VF 425 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=430 nm/475 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D1790

Vari Fluor 640 SE VF 640 SE	Fluorescent Dyes
Vari Fluor 640 SE (VF 640 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=648 nm/664 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-110211

BODIPY TMR-X SE	Fluorescent Dyes
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λ_ex=544 nm, λ_em=570 nm) .

HY-D2353

Biotin-PEG3-benzophenone

Fluorescent Dyes

Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

HY-130736

Janelia Fluor® 549, SE

JF549, SE; JF549, NHS

Fluorescent Dyes

Janelia Fluor® 549, SE (JF549, SE) is a cell-permeable fluorescent dye with an NHS ester (succinimidyl ester (SE)) reactive group. NHS esters react with primary amines and are commonly used to conjugate dyes to proteins, antibodies, amine-modified oligonucleotides, and other molecules. Janelia Fluor® 549, SE also acts as a ligand for self-labeling tags such as HaloTag and SNAP-tag, and can be used in live-cell imaging studies (Ex/Em = 549 nm/571 nm) .\n

HY-D1086

6-Carboxy-X-rhodamine, succinimidyl ester 6-ROX, SE	Fluorescent Dyes
6-Carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) is a fluorescent dye for oligonucleotide labeling and automated DNA sequencing .

HY-D2245

Cy5.5 phosphoramidite	Fluorescent Dyes
Cy5.5 phosphoramidite, a cyanine derivative, is a fluorescent labeling reagent for preparing fluorescence-labeled oligonucleotides .

HY-135414B

Cyanine5 NHS ester iodide 1 Publications Verification	Fluorescent Dyes
Cyanine5 NHS ester iodide is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides .

HY-D1692

BODIPY 650/665 NHS ester	Fluorescent Dyes
BODIPY 650/665 NHS ester is bright, far-red fluorescent dye that can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules . Ex / Em = 646 / 660 nm

HY-D2328A

Alexa Fluor 680 NHS ester diTEA Alexa Fluor 680 succinimidyl ester diTEA	Fluorescent Dyes
Alexa Fluor 680 NHS ester (Alexa Fluor 680 succinimidyl ester) diTEA is a near-infrared (NIR) fluorescent dye. NHS esters can be used to label to the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules (Ex/Em = 679/702 nm) .

HY-D1791

Vari Fluor 750 SE VF 750 SE	Fluorescent Dyes
Vari Fluor 750 SE (VF 750 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=747 nm/770 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.

HY-D2244

Cy3 phosphoramidite	Fluorescent Dyes
Cy3 phosphoramidite?is a fluorescent dye for oligonucleotide labeling.

HY-D2502

Cy7 hydrazide	Fluorescent Dyes
Cy7 hydrazide is a Cy7 (HY-D0825) dye derivative with hydrazine functionality. The hydrazide group of Cy7 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds .

HY-D1409

DMTr-4'-F-U-CED-TBDMS phosphoramidite DMTr-4'-F-uridine-CED-TBDMS phosphoramidite	Fluorescent Dyes
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-D1089

6-JOE, SE	Fluorescent Dyes
6-JOE, SE is an amine-reactive fluorescent probe and is suitable for postsynthetic labeling of amino-modified oligonucleotides .

HY-D1596A

Cyanine 3.5 bromide Cy3.5 NHS ester bromide; Cy 3.5 bromide	Fluorescent Dyes
Cyanine 3.5 bromide (Cy3.5 NHS ester bromide) is an analog of the Cy3.5 fluorophore. Cyanine 3.5 bromide is a red reactive fluorescent dye. Cyanine 3.5 bromide is used to label amino groups in peptides, proteins, and oligonucleotides. (λ_ex=591 nm, λ_em=604 nm) .

Cat. No.	Product Name	Chemical Structure

HY-132580S

Tofersen-d27

Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

HY-W048482S4

rU Phosphoramidite-15N
rU Phosphoramidite- ¹⁵N (DMT-2'O-TBDMS-rU phosphoramidite- ¹⁵N) is ¹⁵N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W048482S3

rU Phosphoramidite-15N2
rU Phosphoramidite- ¹⁵N₂ (DMT-2'O-TBDMS-rU phosphoramidite- ¹⁵N₂) is ¹⁵N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W048482S2

rU Phosphoramidite-13C9
rU Phosphoramidite- ¹³C₉ (DMT-2'O-TBDMS-rU phosphoramidite- ¹³C₉) is ¹³C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W048482S1

rU Phosphoramidite-13C9,15N2
rU Phosphoramidite- ¹³C₉, ¹⁵N₂ (DMT-2'O-TBDMS-rU phosphoramidite- ¹³C₉, ¹⁵N₂) is ¹³C and ¹⁵N-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W048482S

rU Phosphoramidite-13C2,d1
rU Phosphoramidite- ¹³C₂,d₁ (DMT-2'O-TBDMS-rU phosphoramidite- ¹³C₂,d₁) is deuterium and ¹³C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-112754AS

DOTAP-d9 chloride
DOTAP-d₉ chloride is the deuterium labeled DOTAP chloride (HY-112754A). DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-138586S

DMT-dC(ac) Phosphoramidite-13C9, 15N3
DMT-dC(ac) Phosphoramidite- ¹³C₉, ¹⁵N₃ is the ¹³C- and ¹⁵N-labeled DMT-dC(ac) Phosphoramidite (HY-138586). DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis .

Cat. No.	Product Name		Classification

HY-D1314

FAM azide, 6-isomer 6-FAM azide		Azide Labeling and Fluorescence Imaging
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-D2171A

AF488 DBCO ditriethylamine 1 Publications Verification		DBCO
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-D1668

Biotin-11-dCTP		Labeling and Fluorescence Imaging
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important *DNA labeling* reagent*. In random primer DNA labeling* reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-D2746

Cy5.5 bis-NHS ester		Azide
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-D1070

DBCO-PEG4-TAMRA		Labeling and Fluorescence Imaging DBCO
DBCO-PEG4-TAMRA is a PEG-based TAMRA dye and contains a DBCO group, which enables Click Chemistry. The TAMRA dye is a dye widely used in oligonucleotide labeling and automated DNA sequencing applications. DBCO-PEG4-TAMRA is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D2171

AF488 DBCO		DBCO
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-D0820

CY5-YNE Sulfo-Cyanine5-alkyne		Labeling and Fluorescence Imaging Alkynes
CY5-YNE (Sulfo-Cyanine5-alkyne) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides (Ex: 650 nM; Em: 680 nm). CY5-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135835

6-FAM-PEG3-Azide		Azide Labeling and Fluorescence Imaging
6-FAM-PEG3-Azide is a fluorescent dye that can be used to label oligonucleotide . 6-FAM-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151711

Sulfo-Cy5.5 Azide		Azide Labeling and Fluorescence Imaging
Sulfo-Cy5.5 Azide is a click chemistry reagent containing an azide group. Sulfo-Cy5.5 Azide is also a water-soluble dye (Ex=673 nm, Em=707 nm), which designed to label sensitive molecules such as peptides, proteins and oligonucleotides. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D0818

CY3-YNE Sulfo-Cyanine3-alkyne		Alkynes
CY3-YNE (Sulfo-Cyanine3-alkyne) is a dye for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. CY3-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W190937

PC Azido-PEG3-NHS carbonate ester		Azide
PC Azido-PEG3-NHS carbonate ester is a photocleavable linker. It can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-D1893

HEX azide, 6-isomer		Azide
HEX azide, 6-isomer, a derivate of fluorescent dye hexachlorofluorescein (HEX), can be used for labeling oligonucleotides .

HY-147206

Biotin-PEG600-Alk		Alkynes
Biotin-PEG600-Alk is a Biotin-labeled Alkyne functionalized polyethylene glycol. Biotin-PEG600-Alk can be used to modify proteins, peptides, and oligonucleotides . Biotin-PEG600-Alk is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W1052510

N3-PEG2-CH2CO2-NHS		Azide
N3-PEG2-CH2CO2-NHS is a PEG derivative containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Cat. No.	Product Name		Classification

HY-D1409

DMTr-4'-F-U-CED-TBDMS phosphoramidite DMTr-4'-F-uridine-CED-TBDMS phosphoramidite		Phosphoramidites Uracil
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-RI04602C

FAM-MicroRNA Inhibitor Negative Control		MicroRNAs miRNA inhibitors
FAM-MicroRNA Inhibitor Negative Control is a FAM labeled FAM-MicroRNA Inhibitor Negative Control (HY-RI04602). MicroRNA Inhibitor Negative Control is a full-length nucleotide 2'-methoxy modified oligonucleotide, and can be used as a negative control. The sequence of MicroRNA Inhibitor Negative Control is derived from cel-mir-239b. It has minimal sequence identity with miRNAs in human, mouse, and rat.

HY-D1410

DMTr-4'-F-5-Me-U-CED phosphoramidite DMTr-4'-F-5-Methyluridine-CED phosphoramidite		Phosphoramidites Uracil
DMTr-4'-F-5-Me-U-CED phosphoramidite (DMTr-4'-F-5-Methyluridine-CED phosphoramidite), a dye reagent for oligonucleotide labeling, acts as efficient as the incorporation of native deoxyribonucleoside phosphoramidites. DMTr-4'-F-5-Me-U-CED phosphoramidite is a building block .

HY-D1408

DMTr-4'-Me-U-CED-TBDMS phosphoramidite DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite		Phosphoramidites Uracil
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇		Antisense Oligonucleotides
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

HY-D1411

DMTr-4'-CF3-5-Me-U-CED phosphoramidite DMTr-4'-CF3-5-Methyluridine-CED phosphoramidite		Phosphoramidites Uracil
DMTr-4'-CF3-5-Me-U-CED phosphoramidite (DMTr-4'-CF3-5-Methyluridine-CED phosphoramidite), the modified oligodeoxynucleotide (ODN), is a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA research .

HY-149906A

FITC-Trecovirsen sodium FITC-GEM91 sodium		Antisense Oligonucleotides
FITC-Trecovirsen (sodium) is a FITC labeled Trecovirsen. Trecovirsen is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene .

HY-150237

FITC-labeled Drisapersen sodium		Antisense Oligonucleotides
FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.

HY-150751A

Biotin-labeled ODN TTAGGG sodium		CpG ODNs
Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150751B

FITC-labeled ODN TTAGGG sodium		CpG ODNs
FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-150236

FITC-labeled Tominersen sodium		Antisense Oligonucleotides
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-172508

Perylene dU phosphoramidite		Phosphoramidites Uracil
Perylene dU phosphoramidite is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with a quantum yield approaching quantitative. Due to the low lifetime of fluorescence, this probe does not form excimers.With this phosphoramidite, perylene can be introduced into DNA by automated oligonucleotide synthesis.

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