194785-18-7
Chemical Structure
6-ROX
Synonym(s): 6-Carboxy-X-rhodamine
- CAS No.: 194785-18-7
- Formula:C33H30N2O5
- Molecular Weight:534.60
InChIKey: WQZIDRAQTRIQDX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(O)=O)C(C(C2=CC3=C4N(CCC3)CCCC4=C2[O+]=C56)=C5C=C7CCCN8CCCC6=C87)=C1)[O-]
Biological Activity: 6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2[1][2].
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6-ROX | 98.43% | 6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2. | ||||||||||||||||||||
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- [1]. Uddin MJ, et al. Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents. Bioconjug Chem. 2013 Apr 17;24 (4) :712-23. [Content Brief]
- [2]. Butkevich AN, et al. Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry. 2017 Sep 7;23 (50) :12114-12119. [Content Brief]
Keywords
