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pericarp

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By Targets:	Akt (1) Angiotensin-converting Enzyme (ACE) (1) Biochemical Assay Reagents (1) Interleukin Related (1) nAChR (1) SARS-CoV (1) Tie (1) VEGFR (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149373

Garcinone B	Angiotensin-converting Enzyme (ACE) SARS-CoV	Infection
Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen. Garcinone B is a potent ACE2 and Mpro inhibitor. Garcinone B can be used in research of COVID-19 .

HY-N9850

Pomegralignan	Others	Others
Pomegralignan is a glucose ester of neolignan, which can be isolated from the arils and pericarps of Punica granatum L. (pomegranate) .

HY-N19874

Mukurozioside Ia		Metabolic Disease
Mukurozioside Ia is an acyclic sesquiterpene oligoglycoside found in the pericarps of Sapindus rarak. Mukurozioside Ia can be used in the study of metabolic diseases .

HY-N7365

Spathulatol	Others	Others
Spathulatol is a Lignans product that can be isolated from the pericarps of Illicium spathulatum. .

HY-N18367

Lemairamin Wgx-50	nAChR Interleukin Related Akt	Neurological Disease Inflammation/Immunology
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity .

HY-117733

Zerumin A	Tie VEGFR	Cancer
Zerumin A is an anti-angiogenic agent that acts on multiple molecular targets related to angiogenesis (including kdr/VEGFR2, angpt1, angpt2, tie1, and tie2). Zerumin A specifically inhibits the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by regulating the VEGF-VEGFR and ANGPT-TIE signaling pathways, and dose-dependently inhibits angiogenesis (10-20 μM significantly inhibits zebrafish embryo angiogenesis). Zerumin A can be used in the research of cancer and angiogenesis-related inflammatory diseases. Zerumin A can be naturally extracted from the 95% ethanol extract of the fruits, seeds, and pericarp of Alpinia caerulea (R.Br.) Bentham (a plant of the Alpinia genus in the Zingiberaceae family) .

HY-N19827

Monodesmoside saponin C	Biochemical Assay Reagents	Inflammation/Immunology
Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca ²⁺. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca ²⁺ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics .

HY-N17374

Laevigatin A	Others	Others
Laevigatin A (Compound 8) is a hydrolyzable tannin found in Rosa laevigata .

Garcinone B	Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Source Classification	Angiotensin-converting Enzyme (ACE) SARS-CoV
Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen. Garcinone B is a potent ACE2 and Mpro inhibitor. Garcinone B can be used in research of COVID-19 .

Pomegralignan	Monophenols Punica granatum L. Phenols Punicaceae Plants Source Classification	Others
Pomegralignan is a glucose ester of neolignan, which can be isolated from the arils and pericarps of Punica granatum L. (pomegranate) .

Mukurozioside Ia	Structural Classification Terpenoids Sesquiterpenes Sapindaceae Sapindus rarak DC. Plants Source Classification
Mukurozioside Ia is an acyclic sesquiterpene oligoglycoside found in the pericarps of Sapindus rarak. Mukurozioside Ia can be used in the study of metabolic diseases .

Spathulatol	Illicium majus Hook. f. & Thomson Lignans Phenylpropanoids Plants Schisandraceae Source Classification	Others
Spathulatol is a Lignans product that can be isolated from the pericarps of Illicium spathulatum. .

Lemairamin Wgx-50	Zanthoxylum bungeanum Maxim. Structural Classification Simple Phenylpropanols Rutaceae Phenylpropanoids Plants Source Classification	nAChR Interleukin Related Akt
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity .

Zerumin A	Structural Classification Arecaceae Bercht. & J. Presl Ketones, Aldehydes, Acids Terpenoids Arecaceae Diterpenoids Plants Source Classification Zingiberaceae	Tie VEGFR
Zerumin A is an anti-angiogenic agent that acts on multiple molecular targets related to angiogenesis (including kdr/VEGFR2, angpt1, angpt2, tie1, and tie2). Zerumin A specifically inhibits the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by regulating the VEGF-VEGFR and ANGPT-TIE signaling pathways, and dose-dependently inhibits angiogenesis (10-20 μM significantly inhibits zebrafish embryo angiogenesis). Zerumin A can be used in the research of cancer and angiogenesis-related inflammatory diseases. Zerumin A can be naturally extracted from the 95% ethanol extract of the fruits, seeds, and pericarp of Alpinia caerulea (R.Br.) Bentham (a plant of the Alpinia genus in the Zingiberaceae family) .

Monodesmoside saponin C	Triterpenes Structural Classification Terpenoids Sapindus mukorossi Gaertn. Sapindaceae Plants Source Classification	Biochemical Assay Reagents
Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca ²⁺. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca ²⁺ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics .

Laevigatin A	Structural Classification Rosa laevigata Michx. Rosaceae Phenols Polyphenols Plants Source Classification	Others
Laevigatin A (Compound 8) is a hydrolyzable tannin found in Rosa laevigata .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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pericarp

Inhibitors & Agonists

NaturalProducts

Natural
Products