Monodesmoside saponin C

Cat. No.: HY-N19827: Data Sheet Handling Instructions
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Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca²⁺. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca²⁺ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics.

For research use only. We do not sell to patients.

Monodesmoside saponin C Chemical Structure

CAS No. : 84607-60-3

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Description

In Vitro

Monodesmoside saponin C exhibits a calcium ion sequestration capacity of 87.7 mgeq/g at pH 10^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Monodesmoside saponin C (2 mg/kg; into small intestinal loop; single dose) significantly enhances the small intestinal absorption of β-lactam antibiotics in rats, an effect suppressed by co-administered calcium ions but unaffected by solution osmolarity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar (male, 200-230 g, subjected to in situ small intestinal loop procedure)^[1]
Dosage:	2 mg/kg
Administration:	into small intestinal loop; single dose
Result:	Significantly increased ampicillin's maximum blood concentration (Cₘₐₓ) and area under the blood concentration-time curve from 0 to 120 minutes (AUC_0-120) compared to controls. Exerted similar absorption-enhancing effects for other β-lactam antibiotics (cephalin, cephalothin, cefazolin). Demonstrated absorption-promoting effect unaffected by solution osmolarity (280 vs 435 mOsmol/kg H₂O). Had absorption-enhancing effect suppressed by addition of 0.5% CaCl₂·2H₂O, reducing ampicillin's AUC_0-120 to near control levels. Possessed a calcium ion sequestration capacity of 87.7 mgeq/g.

Molecular Weight

883.07

Formula

C₄₆H₇₄O₁₆

CAS No.

84607-60-3

SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C(O)=O)=CC[C@]1([H])[C@@]5([C@@]([C@@](C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O[C@@H]8O[C@H]([C@@H]([C@H]8O)O)CO)O)CO)([H])CC2)C)C

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yata N, et al. Enhanced small intestinal absorption of beta-lactam antibiotics in rats in the presence of monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi). J Pharmacobiodyn. 1986;9(2):211-217.