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Cat. No.: HY-N19827

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Monodesmoside saponin C

Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca²⁺. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca²⁺ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics.

For research use only. We do not sell to patients.

CAS No.: 84607-60-3
Formula: C₄₆H₇₄O₁₆
Molecular Weight:883.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Monodesmoside saponin C Chemical Structure

CAS No.: 84607-60-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

In Vitro

Monodesmoside saponin C exhibits a calcium ion sequestration capacity of 87.7 mgeq/g at pH 10^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Monodesmoside saponin C (2 mg/kg; into small intestinal loop; single dose) significantly enhances the small intestinal absorption of β-lactam antibiotics in rats, an effect suppressed by co-administered calcium ions but unaffected by solution osmolarity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 200-230 g, subjected to in situ small intestinal loop procedure)^[1]
Dosage:

2 mg/kg
Administration:

into small intestinal loop; single dose
Result:

Significantly increased ampicillin's maximum blood concentration (Cₘₐₓ) and area under the blood concentration-time curve from 0 to 120 minutes (AUC_0-120) compared to controls.
Exerted similar absorption-enhancing effects for other β-lactam antibiotics (cephalin, cephalothin, cefazolin).
Demonstrated absorption-promoting effect unaffected by solution osmolarity (280 vs 435 mOsmol/kg H₂O).
Had absorption-enhancing effect suppressed by addition of 0.5% CaCl₂·2H₂O, reducing ampicillin's AUC_0-120 to near control levels.
Possessed a calcium ion sequestration capacity of 87.7 mgeq/g.

Chemical Information

CAS No. 84607-60-3
Molecular Weight 883.07
Formula C₄₆H₇₄O₁₆
SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C(O)=O)=CC[C@]1([H])[C@@]5([C@@]([C@@](C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O[C@@H]8O[C@H]([C@@H]([C@H]8O)O)CO)O)CO)([H])CC2)C)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yata N, et al. Enhanced small intestinal absorption of beta-lactam antibiotics in rats in the presence of monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi). J Pharmacobiodyn. 1986;9(2):211-217. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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