Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
262 Results for "
piperidine
" in MedChemExpress (MCE) Product Catalog:
Products (262)
262 Results for "piperidine" in MCE Product Catalog:
16
16 Publications Verification
Cat. No.: HY-W001187
CAS No.: 2564-83-2
Research Areas:
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
6
Target:
Research Areas:
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders .
6
Target:
Research Areas:
Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders .
4
4 Cited Publications
Cat. No.: HY-P2336A
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride hydrate potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used for the research of parkinsonian .
1
1 Cited Publications
Target:
Research Areas:
Piperidine-4-sulfonic acid is a potent GABA agonist with an IC50 of 0.034 μM for the inhibition of the binding of H-GABA .
1
Target:
TRP Channel Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Keap1-Nrf2 Amyloid-β Fungal Apoptosis
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Dyclonine hydrochloride (Dyclocaine hydrochloride) is an orally active, blood-brain barrier-permeable piperidine phenylacetone small molecule commonly used as a local anesthetic. Dyclonine hydrochloride acts as a highly selective allosteric antagonist of TRPV3; it also reversibly inhibits G9a, ALDH2 and ALDH3A1, non-competitively blocks AChE. Dyclonine hydrochloride activates the Nrf2/ARE pathway, relieves the epigenetic silencing of FXN, blocks Aβ42 aggregation, and promotes remyelination and reparative polarization of microglia. Dyclonine hydrochloride alleviates pruritus via TRPV3 inhibition; it is used in studies of neurodegenerative disease models based on its AChE inhibitory, antioxidant and remyelinating effects; it sensitizes drug-resistant tumors through ALDH inhibition, and combined use with protease inhibitors induces more tumor cell apoptosis; it inhibits Candida albicans in vitro. Dyclonine hydrochloride can be used for research on multiple diseases including neurodegenerative diseases, cancer and pruritic dermatitis .
Target:
Research Areas:
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .
Cat. No.: HY-W045082
CAS No.: 203520-03-0
Target:
Research Areas:
tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-40007
CAS No.: 144222-22-0
Target:
Research Areas:
Fenpropidin, a piperidine, is a fungicide used to control a range of diseases in cereals. Fenpropidin shows antifungal activity against different human pathogenic yeasts and filamentous fungi .
Cat. No.: HY-49390
CAS No.: 2649400-06-4
Research Areas:
(S)-Glutarimide-amide-Py-piperidine-CHO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
Cat. No.: HY-33021
CAS No.: 142355-83-7
Target:
Research Areas:
tert-Butyl 4-(4-hydroxybutyl)piperidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
Research Areas:
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP .
Research Areas:
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
Research Areas:
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively . N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM .
Cat. No.: HY-40008
CAS No.: 135632-53-0
Target:
Research Areas:
4-Boc-aminomethyl-piperidine is a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-40336
CAS No.: 165528-81-4
Target:
Research Areas:
4-(2-Boc-aminoethyl)piperidine is a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-W001613
CAS No.: 660406-84-8
Target:
Research Areas:
tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-W584986
CAS No.: 2616553-33-2
Target:
Research Areas:
Thalidomide-(2)piperidine (compound 9) is a potent E3 ligase ligand. Thalidomide-(2)piperidine can be used for synthesis of PROTACs .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
