1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Metixene hydrochloride hydrate

Metixene hydrochloride hydrate 

Cat. No.: HY-120081A Purity: 99.85%
Handling Instructions

Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM.

For research use only. We do not sell to patients.

Metixene hydrochloride hydrate Chemical Structure

Metixene hydrochloride hydrate Chemical Structure

CAS No. : 7081-40-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1].

IC50 & Target

IC50: 55 nM (mAChR)[1]
Ki: 15 nM (mAChR)[1]

In Vitro

Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1].

Molecular Weight

363.94

Formula

C₂₀H₂₆ClNOS

CAS No.

7081-40-5

SMILES

CN1CC(CCC1)CC2C3=C(C=CC=C3)SC4=C2C=CC=C4.Cl.O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 90 mg/mL (247.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7477 mL 13.7385 mL 27.4771 mL
5 mM 0.5495 mL 2.7477 mL 5.4954 mL
10 mM 0.2748 mL 1.3739 mL 2.7477 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.85%

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Product Name:
Metixene hydrochloride hydrate
Cat. No.:
HY-120081A
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