1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Cyproheptadine hydrochloride

Cyproheptadine hydrochloride 

Cat. No.: HY-B0366A Purity: 99.98%
Handling Instructions

Cyproheptadine hydrochloride is a 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders.

For research use only. We do not sell to patients.

Cyproheptadine hydrochloride Chemical Structure

Cyproheptadine hydrochloride Chemical Structure

CAS No. : 969-33-5

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cyproheptadine hydrochloride is a 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders[1][2].

IC50 & Target[1]

5-HT2 Receptor

 

In Vitro

Cyproheptadine hydrochloride (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro[2].
Cyproheptadine hydrochloride (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro[2].
Cyproheptadine hydrochloride inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyproheptadine hydrochloride (1 mg/kg; daily; for 5 days) exerts thromboprotective properties in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (8-10 weeks old)[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection, daily, for 5 days
Result: Prolonged occlusion times and tail bleeding times in mice.
Clinical Trial
Molecular Weight

323.86

Formula

C₂₁H₂₂ClN

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (154.39 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0878 mL 15.4388 mL 30.8775 mL
5 mM 0.6176 mL 3.0878 mL 6.1755 mL
10 mM 0.3088 mL 1.5439 mL 3.0878 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Cyproheptadine hydrochloride
Cat. No.:
HY-B0366A
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