1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. DNA/RNA Synthesis
    Reactive Oxygen Species
    Mitochondrial Metabolism
  3. Tempo

Tempo 

Cat. No.: HY-W001187 Purity: >95.0%
Handling Instructions

Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects.

For research use only. We do not sell to patients.

Tempo Chemical Structure

Tempo Chemical Structure

CAS No. : 2564-83-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Tempo

    Tempo purchased from MCE. Usage Cited in: Br J Cancer. 2020 May 5.

    Radiation inhibits AKT phosphorylation, and Tempo could alleviate the IDH2 knockdown-induced decrease in AKT phosphorylation in both the steady state and after ROS induction by radiation.
    • Biological Activity

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    Description

    Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].

    Clinical Trial
    Molecular Weight

    171.28

    Formula

    C₁₀H₂₁NO?

    CAS No.

    2564-83-2

    SMILES

    CN1C(C)(C)CCCC1(C)C.[O]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (583.84 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.8384 mL 29.1920 mL 58.3839 mL
    5 mM 1.1677 mL 5.8384 mL 11.6768 mL
    10 mM 0.5838 mL 2.9192 mL 5.8384 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: >95.0%

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    Keywords:

    TempoDNA/RNA SynthesisReactive Oxygen SpeciesMitochondrial MetabolismSODantioxidantpiperidinenitroxidecatalyticradicaldismutasescytotoxicitymutagenicDNA-strandInhibitorinhibitorinhibit

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    Product Name:
    Tempo
    Cat. No.:
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