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Results for "

pleiotropic

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

1

Screening Libraries

9

Peptides

5

Natural
Products

1

Isotope-Labeled Compounds

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17571
    Oxytocin
    Maximum Cited Publications
    24 Publications Verification

    α-Hypophamine; Oxytocic hormone

    		 Oxytocin Receptor Endogenous Metabolite Endocrinology Cancer
    Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
    Oxytocin
  • HY-17571A
    Oxytocin acetate
    Maximum Cited Publications
    24 Publications Verification

    α-Hypophamine acetate; Oxytocic hormone acetate

    		 Oxytocin Receptor Endogenous Metabolite Endocrinology Cancer
    Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
    Oxytocin acetate
  • HY-122506
    Salviolone

    		STAT Cancer
    Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .
    Salviolone
  • HY-10252
    NVP-ADW742
    3 Publications Verification

    ADW742; GSK 552602A; ADW

    		 IGF-1R Insulin Receptor Apoptosis Endocrinology Cancer
    NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
    NVP-ADW742
  • HY-W011151
    trans-Zeatinriboside
    1 Publications Verification

    		 Phytohormone Others
    trans-Zeatinriboside is a zeatin-type cytokinin and plant growth regulator. trans-Zeatinriboside is produced by the terrestrial filamentous cyanobacterium Nostoc sp. HK-01 and Agrobacterium tumefaciens (including Ti plasmid-dependent and Ti plasmid-independent strains). trans-Zeatinriboside is detectable as a cytokinin component in growing crown galls, and accumulates in large amounts in CHRK1-silenced transgenic tobacco accompanied by pleiotropic developmental abnormalities. trans-Zeatinriboside can be used in studies related to crown galls .
    trans-Zeatinriboside
  • HY-N2191
    Ecliptasaponin D

    		Others Inflammation/Immunology
    Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba (L.) Hassk which is the aerial part of Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant and immunomodulatory [1,2].
    Ecliptasaponin D
  • HY-P2948
    Protein serine/threonine kinase

    Ser/Thr protein kinase

    		 Biochemical Assay Reagents Infection
    Protein serine/threonine kinase is a type of serine/threonine protein kinase. Protein serine/threonine kinases are pleiotropic signaling proteins that can phosphorylate various substrates, thereby initiating branched signaling pathways. Mycobacteria protein serine/threonine kinase plays a crucial role in signal transduction pathways, ultimately determining the growth and metabolic adaptability of mycobacteria .
    Protein serine/threonine kinase
  • HY-P3395
    Catestatin (human)

    Human chromogranin A 352–372

    		 nAChR Cardiovascular Disease Inflammation/Immunology
    Catestatin human, a catecholamine release-inhibitory peptide, is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Catestatin human can be used in the study of inflammatory diseases .
    Catestatin (human)
  • HY-P1882
    Type A Allatostatin I

    		Insecticide Inflammation/Immunology
    Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .
    Type A Allatostatin I
  • HY-P3216
    Oxytocin free acid

    9-Deamidooxytocin

    		 Oxytocin Receptor Endocrinology
    Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .
    Oxytocin free acid
  • HY-P3216B
    Oxytocin free acid TFA
    10+ Cited Publications

    9-Deamidooxytocin TFA

    		 Oxytocin Receptor Endocrinology
    Oxytocin free acid (9-Deamidooxytocin) TFA is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .
    Oxytocin free acid TFA
  • HY-P1786
    Allatostatin II

    		Potassium Channel Neurological Disease
    Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .
    Allatostatin II
  • HY-167836
    BNN-20

    		Trk Receptor Neurological Disease
    BNN-20 is a synthetic microneurotrophin that mimics brain-derived neurotrophic factor (BDNF) and exhibits area-specific pleiotropic neuroprotective and pro-neurogenic effects. BNN-20 can be utilized in research related to Parkinson's disease .
    BNN-20
  • HY-P4720
    Interleukin-6 fragment (human)

    		Interleukin Related Inflammation/Immunology Cancer
    Interleukin-6 fragment (human) is a pleiotropic cytokine produced by lymphocytes and non-lymphocytes. The Interleukin-6 fragment (human) coding gene is located on human chromosome 7, with a length of approximately 5 kilobases. Interleukin-6 fragment (human) has potential applications in immune response, acute response, inflammation, tumors, and hematopoiesis .
    Interleukin-6 fragment (human)
  • HY-134666A
    Dioctatin A hydrochloride

    		Dipeptidyl Peptidase Fungal Bacterial Infection
    Dioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC50 of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites .
    Dioctatin A hydrochloride
  • HY-10252A
    cis-NVP-ADW742

    cis-ADW742; cis-GSK 552602A; cis-ADW

    		 IGF-1R Insulin Receptor Apoptosis Inflammation/Immunology
    cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
    cis-NVP-ADW742
  • HY-E70867
    TGFβR2 Recombinant Human Active Protein Kinase

    		TGF-β Receptor Metabolic Disease
    TGF-β is a pleiotropic multifunctional cytokine that regulates many cellular processes, such as cell growth, differentiation, apoptosis and cellular homeostasis. Before exerting the biological effects within cells, TGF-β first requires extracellular activation, namely binds to its type II receptor (TGFβR2) and promotes the phosphorylation. TGFβR1 plays an important role in TGF-β signaling transduction and serves as a tumor suppressor. TGFβR2 Recombinant Human Active Protein Kinase is a recombinant TGFβR2 protein that can be used to study TGFβR2-related functions .
    TGFβR2 Recombinant Human Active Protein Kinase
  • HY-P1760
    Allatostatin IV

    		Insecticide Neurological Disease
    Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .
    Allatostatin IV
  • HY-174634
    Human IL16 mRNA

    		mRNA Inflammation/Immunology
    Human IL16 mRNA encodes the human interleukin 16 (IL16) protein, a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication.
    Human IL16 mRNA
  • HY-174628
    Human IL1A mRNA

    		mRNA Inflammation/Immunology
    Human IL1A mRNA encodes the human interleukin 1 alpha (IL1A) protein, a member of the interleukin 1 cytokine family. IL1A is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis.
    Human IL1A mRNA
  • HY-149004A
    SLF1081851 TFA

    		LPL Receptor Inflammation/Immunology
    SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system .
    SLF1081851 TFA
  • HY-174604
    Human IL4 mRNA

    		mRNA Inflammation/Immunology
    Human IL4 mRNA encodes the human interleukin 4 (IL4) protein, a pleiotropic cytokine produced by activated T cells. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4 mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.
    Human IL4 mRNA
  • HY-129284
    APHS

    		COX Wnt Cancer
    APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition .
    APHS
  • HY-10252R
    NVP-ADW742 (Standard)

    ADW742 (Standard); GSK 552602A (Standard); ADW (Standard)

    		 Reference Standards IGF-1R Insulin Receptor Apoptosis Endocrinology Cancer
    NVP-ADW742 (Standard) is the analytical standard of NVP-ADW742 (HY-10252). This product is intended for research and analytical applications. NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
    NVP-ADW742 (Standard)
  • HY-174599
    Human IL6R mRNA

    		mRNA Inflammation/Immunology
    Human IL6R mRNA encodes the human interleukin 6 receptor (IL6R) protein, a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
    Human IL6R mRNA
  • HY-17571S
    Oxytocin-13C6,15N TFA

    α-Hypophamine-13C6,15N TFA; Oxytocic hormone-13C6,15N TFA

    		 Isotope-Labeled Compounds Oxytocin Receptor Endogenous Metabolite Metabolic Disease Cancer
    Oxytocin- 13C6, 15N (α-Hypophamine- 13C6, 15N) TFA is the 13C- and 15N-labeled Oxytocin TFA. Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
    Oxytocin-13C6,15N TFA

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