475489-15-7
Chemical Structure
cis-NVP-ADW742
Synonym(s): cis-ADW742; cis-GSK 552602A; cis-ADW
- CAS No.: 475489-15-7
- Formula:C28H31N5O
- Molecular Weight:453.58
IUPAC Name: 5-(3-(benzyloxy)phenyl)-7-((1s,3s)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChIKey: LSFLAQVDISHMNB-DKXQDJALSA-N
SMILES: NC1=C2C(N([C@H]3C[C@@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Biological Activity: cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells[1][2].
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cis-NVP-ADW742 | cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells. | |||||||||||||||||||||
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