Search Result
Results for "
racemic mixture
" in MedChemExpress (MCE) Product Catalog:
8
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-131904
-
POMHEX
3 Publications Verification
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Enolase
Apoptosis
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Metabolic Disease
Cancer
|
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POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor .
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-
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- HY-134818
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ML-SI1
Maximum Cited Publications
6 Publications Verification
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TRP Channel
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Neurological Disease
|
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ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1 .
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-
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- HY-B2236
-
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(±)-2,6-Diaminocaproic acid
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Endogenous Metabolite
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Metabolic Disease
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DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins .
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-
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- HY-N7142S
-
|
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Adrenergic Receptor
|
Neurological Disease
Metabolic Disease
|
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DL-Norepinephrine-d6 hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
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-
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- HY-110406A
-
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13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide
|
Endogenous Metabolite
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Others
|
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(±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase .
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-
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- HY-118590
-
|
|
Topoisomerase
DNA/RNA Synthesis
Apoptosis
Fungal
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Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
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ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
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-
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- HY-103019A
-
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(±)-BAY-1251152; (±)-VIP152
|
CDK
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
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(±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
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-
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- HY-14545
-
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(Rac)-Aramisulpride; (Rac)-Esamisulpride; DAN 2163
|
Dopamine Receptor
5-HT Receptor
|
Neurological Disease
|
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Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research .
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- HY-Y1315
-
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Biochemical Assay Reagents
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Endocrinology
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DL-Tartaric acid is an orally active and non-racemic mixture of L- and D-tartaric acid with antioxidant activity. 14C-labeled DL-Tartaric acid is nephrotoxic .
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- HY-N7142
-
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Adrenergic Receptor
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Neurological Disease
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DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
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- HY-135026
-
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Adrenergic Receptor
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Neurological Disease
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DL-Norepinephrine tartrate is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine tartrate after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
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-
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- HY-137258
-
|
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Cytochrome P450
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Metabolic Disease
|
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(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively .
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- HY-W012908
-
|
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Biochemical Assay Reagents
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Infection
Cancer
|
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DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection .
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-
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- HY-113764
-
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(Rac)-C4-HSL
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Bacterial
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Infection
Inflammation/Immunology
|
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N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
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- HY-173630A
-
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Molecular Glues
IKZF Family
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Cancer
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(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .
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- HY-15997
-
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(-)-Trans-(1S,2S)-U-50488 hydrochloride
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Opioid Receptor
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Infection
Cancer
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(-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+)?trans-(1R,2R) U-50488 (HY-15997A)?or the (±)?trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM) .
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- HY-15997B
-
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(±)-Trans-(1R,2R)-U-50488 hydrochloride
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Opioid Receptor
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Neurological Disease
|
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(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist .
|
-
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- HY-W041895
-
|
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Endogenous Metabolite
DNA/RNA Synthesis
Bacterial
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Infection
|
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DL-Glutamic acid is a racemic amino acid mixture and an antibacterial agent. DL-Glutamic acid reduces RNA and DNA levels, with a more significant effect on RNA. DL-Glutamic acid inhibits cell division of Rhodospirillum rubrum .
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- HY-100841
-
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3HPG
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mGluR
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Neurological Disease
|
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(Rac)-3-Hydroxyphenylglycine (3HPG) is a racemic mixture of (S)-3-hydroxyphenylglycine and (R)-3-hydroxyphenylglycine. (S)-3-Hydroxyphenylglycine is a potent and selective mGluR1 agonist .
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- HY-N7142S3
-
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|
Isotope-Labeled Compounds
Adrenergic Receptor
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Cardiovascular Disease
Neurological Disease
|
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DL-Norepinephrine-d6 is the deuterium labeled DL-Norepinephrine. DL-Norepinephrine is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
|
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- HY-135113
-
|
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Amino Acid Derivatives
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Others
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DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.
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- HY-130319A
-
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PPAR
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Cardiovascular Disease
Metabolic Disease
|
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9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo .
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- HY-116663
-
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(±)20-HDoHE
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Endogenous Metabolite
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Neurological Disease
|
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(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .
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- HY-178193A
-
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DNA/RNA Synthesis
Akt
PD-1/PD-L1
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Cancer
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(Rac)-Chem-0199 is the racemic mixture of Chem-0199 (HY-178193). Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer .
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- HY-15997C
-
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(±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride
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Opioid Receptor
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Neurological Disease
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(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist .
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- HY-151525A
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YAP
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Cancer
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(R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2 (HY-151525). YAP-TEAD-IN-2 (Compound 6) is a potent inhibitor of YAP-TEAD PPIs (protein-protein interaction) with an IC50 of 2.7 nM .
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- HY-121987A
-
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Lipoxygenase
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Inflammation/Immunology
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(±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM).
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- HY-N7142S1
-
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Adrenergic Receptor
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Neurological Disease
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DL-Norepinephrine-d3 hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease.
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- HY-130675
-
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(±)15-hydroxyeicosapentaenoic acid; 15-OHEPA
|
Lipoxygenase
Bacterial
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Metabolic Disease
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(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.
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- HY-B0399A
-
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DL-Carnitine; DL-Levocarnitine
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Mitochondrial Metabolism
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Metabolic Disease
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(±)-Carnitine (DL-Carnitine) is an orally effective racemic mixture of L-Carnitine (HY-B0399) and D-Carnitine. (±)-Carnitine elevates the mitochondrial NAD +/NADH ratio in the presence of 1,3-butanediol (HY-77490A). (±)-Carnitine does not increase glucose and urea production from L-glutamine, but stimulates propionate gluconeogenesis in rat renal cortical slices, and significantly reduces hepatic ketone body levels in rats fed a diet containing 30% high fat plus 20% 1,3-butanediol .
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- HY-100869B
-
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WDR5
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Cancer
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MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
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- HY-B2236A
-
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(±)-2,6-Diaminocaproic acid monohydrate
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Biochemical Assay Reagents
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Metabolic Disease
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DL-Lysine monohydrate is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins .
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- HY-145263A
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-
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- HY-W295313
-
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Drug Derivative
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Others
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(+)-Neoisomenthol is one of the isomers of (±)-Neoisomenthol. (±)-Neoisomenthol is a compound that belongs to the class of monoterpenes. (±)-Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. It is a chiral compound, existing as a racemic mixture of two enantiomers, (+)-neoisomenthol and (-)-neoisomenthol.
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- HY-106601A
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LY-150720 hydrochloride
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Opioid Receptor
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Neurological Disease
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Picenadol (LY-150720) hydrochloride is an opioid mixed agonist-antagonist analgesic. Picenadol hydrochloride is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol hydrochloride has anticholinergic activity .
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- HY-120109
-
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Endogenous Metabolite
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Cancer
|
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13-HODE methyl ester, a racemic mixture of 13(R)-HODE methyl ester and 13(S)-HODE methyl ester, is a 15-lipoxygenase metabolite of Linoleic acid .
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- HY-107370A
-
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(Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603
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Serotonin Transporter
Sodium Channel
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Metabolic Disease
Cancer
|
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(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na + channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
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- HY-118590A
-
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Topoisomerase
DNA/RNA Synthesis
Apoptosis
Fungal
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Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
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ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is a DNA Topoisomerase II inhibitor. ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
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-
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- HY-10011B
-
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CXCR
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Inflammation/Immunology
Endocrinology
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(Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively .
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- HY-12993A
-
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A-60444 racemate
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RSV
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Others
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RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
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-
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- HY-172009
-
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Drug Isomer
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Others
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8-Amino-7-oxononanoic acid hydrochloride is a racemic mixture of 8(R)-KAPA and the vitamer of biotin 8(S)-KAPA.
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-
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- HY-W178699
-
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Drug Derivative
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Others
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(±)-Neoisomenthol is a monoterpene. (±)-Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. (±)-Neoisomenthol is a chiral compound, existing as a racemic mixture of two enantiomers, (+)-Neoisomenthol and (-)-Neoisomenthol .
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- HY-W010143
-
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(Rac)-Norcotinine
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Drug Metabolite
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Cardiovascular Disease
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(R,S)-Norcotinine ((Rac)-Norcotinine) is the racemic mixture of Norcotinine. (R,S)-Norcotinine is a biomarker of secondhand smoke exposure and is associated with the toxic mechanisms of secondhand smoke on cardiovascular development .
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-
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- HY-I0635
-
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(Rac)-CC-10004
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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(Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast has anti-inflammatory properties and can be used for research on inflammatory diseases, such as psoriasis .
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- HY-130310B
-
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11-hydroxy-12,14-Eicosadienoic acid
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COX
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Metabolic Disease
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(±)11-HEDE is a racemic mixture of the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE. 11-HEDE is formed from eicosadienoic acid by cyclooxygenase (COX) and in macrophages.
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- HY-112438A
-
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Deubiquitinase
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Cancer
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rac-MF-094 is the racemic mixture of MF-094 (HY-112438). MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy .
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-
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- HY-Y1315R
-
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Biochemical Assay Reagents
Reference Standards
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Others
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DL-Tartaric acid (Standard) is the analytical standard of DL-Tartaric acid. This product is intended for research and analytical applications. DL-Tartaric acid is a non-racemic mixture of L- and D-tartaric acid with antioxidant activity. 14C-labeled DL-Tartaric acid is nephrotoxic .
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-
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- HY-B0105BS
-
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(-)-Ketoconazole-d3; (-)-Ketoconazol-d3; (-)-R 41400-d3
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Isotope-Labeled Compounds
Fungal
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Infection
Inflammation/Immunology
|
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(-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
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-
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- HY-B2236S3
-
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(±)-2,6-Diaminocaproic acid-15N2 hydrochloride
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Isotope-Labeled Compounds
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Metabolic Disease
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DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is 15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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-
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- HY-B2236S1
-
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(±)-2,6-Diaminocaproic acid-13C6 hydrochloride
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Isotope-Labeled Compounds
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Metabolic Disease
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DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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-
- HY-176106
-
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Opioid Receptor
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Others
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1-Naphthyl U-47700 is an α-isomer. 1-Naphthyl U-47700 is a racemic mixtures of the trans-isomers [R,R and S,S]. 1-Naphthyl U-47700 activates MOR in a concentration-dependent manner (EC50 > 23 μM) .
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- HY-126108
-
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Others
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Metabolic Disease
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(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of (±)8-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.
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- HY-12364C
-
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(+)-C75
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Carnitine Palmitoyltransferase (CPT)
Mitochondrial Metabolism
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Others
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(+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent .
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- HY-118091
-
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5 alpha Reductase
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Endocrinology
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LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selective human type I 5α-reductase inhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by 5α-reductase type 1 .
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- HY-B2236S2
-
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(±)-2,6-Diaminocaproic acid-13C6,15N2 hydrochloride
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Isotope-Labeled Compounds
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Metabolic Disease
|
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DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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- HY-B0827A
-
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(R)-MTI-446
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nAChR
Parasite
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Infection
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(R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, exhibits comparative insecticidal activities (1.7-2.4 times) to typical sucking pests Aphis gossypii and Apolygus lucorum compared to racemic mixtures by inhibiting nicotinic acetylcholine receptors. (R)-Dinotefuran has a good efficacy in controlling target pests while minimizing hazard to honeybees .
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- HY-106601
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LY-150720
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Opioid Receptor
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Neurological Disease
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Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity .
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- HY-W1005647
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Biochemical Assay Reagents
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Others
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(rac)-Isoleucine is the racemic form of Isoleucine. Isoleucine is a mixture of the diastereomers L-isoleucine, L-alloisoleucine, D-isoleucine, and D-alloisoleucine. L-isoleucine is a branched-chain amino acid that acts as a nitrogen donor, and has roles in glucose consumption, fatty acid metabolism, as well as immune function. L-Alloisoleucine is generated by transamination of L-isoleucine. D-Isoleucine and D-alloisoleucine are enantiomers of L-isoleucine and L-alloisoleucine, respectively .
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- HY-19202
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rac-EMA401; rac-PD-126055; EMA400
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Angiotensin Receptor
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Neurological Disease
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rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve .
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- HY-116790B
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(Rac)-Penbutolol; (±)-Isopenbutolol
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Adrenergic Receptor
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Cardiovascular Disease
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(±)-Penbutolol ((Rac)-Penbutolol) is the racemic mixture of Penbutolol. (±)-Penbutolol is an orally active β-adrenergic receptor antagonist. (±)-Penbutolol antagonizes exercise-induced tachycardia, reduces the increase in peak expiratory flow rate (PEFR) caused by exercise, and decreases resting plasma renin activity (PRA). (±)-Penbutolol reaches peak plasma concentration 1 hour after oral administration, with a half-life of 4.5 hours, and is converted into an active metabolite in the body. (±)-Penbutolol can be used in cardiovascular-related disease research .
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- HY-137390A
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HMG-CoA Reductase (HMGCR)
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Cardiovascular Disease
Metabolic Disease
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(3S,5R)-Fluvastatin (potassium) is a synthetic hypolipidemic drug that inhibits HMG-CoA reductase activity. (3S,5R)-Fluvastatin (potassium) has similar antioxidative effects on copper ion-induced LDL oxidation compared to its 3R,5S enantiomer. (3S,5R)-Fluvastatin (potassium) and its metabolites demonstrate a potential to exhibit anti-atherosclerotic effects through their antioxidative activities. (3S,5R)-Fluvastatin (potassium) is clinically utilized as part of a racemic mixture for reducing plasma cholesterol levels.
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- HY-113764R
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(Rac)-C4-HSL (Standard)
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Bacterial
Reference Standards
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Infection
Inflammation/Immunology
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N-Butanoyl-DL-homoserine lactone (Standard) is the analytical standard of N-Butanoyl-DL-homoserine lactone. This product is intended for research and analytical applications. N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
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- HY-10011BR
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CXCR
Reference Standards
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Inflammation/Immunology
Endocrinology
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(Rac)-SCH 563705 (Standard) is the analytical standard of (Rac)-SCH 563705 (HY-10011B). This product is intended for research and analytical applications. (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively .
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- HY-181475
-
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Drug Derivative
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Inflammation/Immunology
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8,12-Iso-iPF2α-VI-1,5-lactone is a racemic mixture of the lactone form of the free acid 8,12-iso-iPF2α-VI, and is used in studies of immune-related diseases .
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- HY-172008
-
-
- HY-P2986A
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Endogenous Metabolite
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Metabolic Disease
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D-Amino Acid Oxidase, Porcine (EC 1.4.3.3) is used in the measurement of D-alanine and FAD, and in the preparation of L-amino acids from racemic mixtures.
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- HY-Z16647
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Others
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Others
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(-) -Neoisomenthol is one of the isomers of (±) -Neoisomenthol. (±) -Neoisomenthol is a compound that belongs to the class of monoterpenes. (±) -Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. It is a chiral compound, existing as a racemic mixture of two enantiomers, (+) -neoisomenthol and (-) -neoisomenthol.
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- HY-B2236S
-
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(±)-2,6-Diaminocaproic acid-d4 dihydrochloride
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Isotope-Labeled Compounds
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Metabolic Disease
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DL-Lysine-4,4,5,5-d4 (dihydrochloride) is the deuterium labeled DL-Lysine. DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins .
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- HY-N1384A
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Biochemical Assay Reagents
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Others
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(rac)-Ambroxide is a racemic mixture of Ambroxide (HY-N1384). Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris. Ambroxide is used in the manufacture of high-end perfumes to improve the aroma quality and fragrance lasting time of perfumes .
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- HY-137258A
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Drug Isomer
Cytochrome P450
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Metabolic Disease
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(R)-N-3-Benzylnirvanol is the R-isomer of (±)-N-3-Benzylnirvanol (HY-137258). (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively .
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- HY-162596A
-
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(Rac)-BA-1049
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ROCK
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Neurological Disease
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(Rac)-NRL-1049 is the racemic mixture of NRL-1049 (BA-1049 (free base)) (HY-162596). NRL-1049 is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .
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- HY-W076861
-
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Amino Acid Derivatives
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Infection
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3-Amino-3-(4-methoxyphenyl)propanoic acid is a β-amino acid. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be stereoselectively synthesized using alanine as an amino donor and 3-(4-methoxyphenyl)3-oxopropanoic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be enantiomerically enriched from a racemic mixture using pyruvic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be used for research of bacterial and fungal infections .
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- HY-103019AR
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(±)-BAY-1251152 (Standard); (±)-VIP152 (Standard)
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Reference Standards
CDK
Apoptosis
DNA/RNA Synthesis
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Cancer
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(±)-Enitociclib (Standard) is the analytical standard of (±)-Enitociclib (HY-103019A). This product is intended for research and analytical applications. (±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W012908
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Biochemical Assay Reagents
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Infection
Cancer
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DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection .
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-
- HY-135113
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Amino Acid Derivatives
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Others
|
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DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-N7142S
-
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DL-Norepinephrine-d6 hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
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-
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- HY-N7142S3
-
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DL-Norepinephrine-d6 is the deuterium labeled DL-Norepinephrine. DL-Norepinephrine is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .
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-
-
- HY-N7142S1
-
|
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DL-Norepinephrine-d3 hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease.
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-
-
- HY-B0105BS
-
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(-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
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-
-
- HY-B2236S3
-
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DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is 15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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-
-
- HY-B2236S1
-
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DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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-
-
- HY-B2236S2
-
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DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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-
-
- HY-B2236S
-
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DL-Lysine-4,4,5,5-d4 (dihydrochloride) is the deuterium labeled DL-Lysine. DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins .
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