114528-79-9

(-)-U-50488 hydrochloride Chemical Structure
114528-79-9

Chemical Structure

(-)-U-50488 hydrochloride

Synonym(s): (-)-Trans-(1S,2S)-U-50488 hydrochloride

  • CAS No.: 114528-79-9
  • Formula:C19H27Cl3N2O
  • Molecular Weight:405.79

IUPAC Name: 2-(3,4-dichlorophenyl)-N-methyl-N-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)acetamide hydrochloride

InChIKey: KGMMGVIYOHGOKQ-APTPAJQOSA-N

SMILES: O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl

Biological Activity: (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) over μ-opioid receptor (MOR) (Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM)[1].

Cat. No. Product Name Purity Description Pricing
HY-15997 		(-)-U-50488 hydrochloride 98.95% (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) over μ-opioid receptor (MOR) (Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM).
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