71675-85-9
71675-85-9
Chemical Structure
Amisulpride
Synonym(s): (Rac)-Aramisulpride;(Rac)-Esamisulpride; DAN 2163
- CAS No.: 71675-85-9
- Formula:C17H27N3O4S
- Molecular Weight:369.48
IUPAC Name: 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
InChIKey: NTJOBXMMWNYJFB-UHFFFAOYSA-N
SMILES: CCN1C(CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1
Biological Activity: Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amisulpride | 99.77% | Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research. | ||||||||||||||||||||
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Amisulpride (Standard) | ≥98% | Amisulpride (Standard) is the analytical standard of Amisulpride. This product is intended for research and analytical applications. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | ||||||||||||||||||||
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Amisulpride-d5 | 98.73% | Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | ||||||||||||||||||||
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Aramisulpride | 98.49% | Aramisulpride (R-(+)-Amisulpride) is the R-isomer of Amisulpride (HY-14545). Aramisulpride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride can be used in psychiatric research. | ||||||||||||||||||||
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Aramisulpride hydrochloride | Aramisulpride hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride hydrochloride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride hydrochloride can be used in psychiatric research. | |||||||||||||||||||||
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Alpiropride | Alpiropride (RIV-2093) is a metoclopramide (HY-17382) analog that is effective in reducing the gastrointestinal side effects of cancer chemotherapy drugs. In animal studies, alpiropride showed a stronger antiemetic effect than metoclopramide. | |||||||||||||||||||||
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Esamisulpride | 99.04% | Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine D2/D3 receptor antagonist with Ki values of 4.43 nM for D2R and 0.72 nM for D3R. Esamisulpride is a 5-HT7 receptor antagonist with a Ki of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression. | ||||||||||||||||||||
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Amisulpride hydrochloride | 99.79% | Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | ||||||||||||||||||||
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Amisulpride-d5 N-Oxide | Amisulpride-d5 N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | |||||||||||||||||||||
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LB-102 | 98.75% | LB-102 is an orally active inhibitor of dopamine D2, D3, and 5-HT7 receptors, which can be used in research on schizophrenia and other psychiatric disorders. | ||||||||||||||||||||
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Sultopride | Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor. | |||||||||||||||||||||
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Sultopride hydrochloride | 99.89% | Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor. | ||||||||||||||||||||
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Amisulpride N-oxide | Amisulpride N-oxide is a photodegradation product of Amisulpride (HY-14545) (a dopamine D2/D3 receptor antagonist). | |||||||||||||||||||||
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Desmethyl amisulpride-d5 hydrobromide | Desmethyl amisulpride-d5 hydrobromide is the deuterium labeled Desmethyl amisulpride hydrobromide. | |||||||||||||||||||||
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References
- [1]. Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97. [Content Brief]
- [2]. Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66(3):327-31. [Content Brief]
