Aramisulpride hydrochloride
Aramisulpride hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride hydrochloride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride hydrochloride can be used in psychiatric research.
For research use only. We do not sell to patients.
- CAS No.: 2129505-46-8
- Formula: C17H28ClN3O4S
- Molecular Weight:405.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT7 Receptor 22 nM (Ki) |
D2 Receptor 140 nM (Ki) |
D3 Receptor 13.9 nM (Ki) |
Chemical Information
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CAS No. 2129505-46-8
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Molecular Weight 405.94
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Formula C17H28ClN3O4S
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SMILES
CCN(CCC1)[C@H]1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O.Cl
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Synonyms
(R)-Amisulpride hydrochloride; (R)-Esamisulpride hydrochloride; (R)-DAN 2163 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7. ACS Omega. 2019 Aug 15;4(9):14151-14154. [Content Brief]
[2]. Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110(3):808-815. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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