Aramisulpride hydrochloride (Synonyms: (R)-Amisulpride hydrochloride; (R)-Esamisulpride hydrochloride; (R)-DAN 2163 hydrochloride)

Cat. No.: HY-109167A: Data Sheet Handling Instructions
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Aramisulpride hydrochloride is a 5-HT₇ receptor antagonist with a K_i value of 22 nM. Aramisulpride hydrochloride is a D₂/D₃ receptor antagonist with a K_i value of 140 nM for D₂R and a K_i value of 13.9 nM for D₃R. Aramisulpride hydrochloride can be used in psychiatric research.

For research use only. We do not sell to patients.

Aramisulpride hydrochloride Chemical Structure

CAS No. : 2129505-46-8

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Other In-stock Forms of Aramisulpride hydrochloride:

Aramisulpride

Other Forms of Aramisulpride hydrochloride:

Aramisulpride In-stock

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

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5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

5-HT₇ Receptor

22 nM (Ki)

D₂ Receptor

140 nM (Ki)

D₃ Receptor

13.9 nM (Ki)

Molecular Weight

405.94

Formula

C₁₇H₂₈ClN₃O₄S

CAS No.

2129505-46-8

SMILES

CCN(CCC1)[C@H]1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D₂ and D₃, while R Enantiomers Engage 5-HT₇. ACS Omega. 2019 Aug 15;4(9):14151-14154. [Content Brief]

[2]. Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110(3):808-815. [Content Brief]

Aramisulpride hydrochloride Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aramisulpride2129505-46-8(R)-Amisulpride(R)-Esamisulpride(R)-DAN 2163Dopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT7D2D3psychiatricneurologicalInhibitorinhibitorinhibit

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