2129505-46-8
2129505-46-8
Chemical Structure
Aramisulpride hydrochloride
Synonym(s): (R)-Amisulpride hydrochloride; (R)-Esamisulpride hydrochloride; (R)-DAN 2163 hydrochloride
- CAS No.: 2129505-46-8
- Formula:C17H28ClN3O4S
- Molecular Weight:405.94
InChIKey: XFOYXFDTUMXXFP-UTONKHPSSA-N
SMILES: CCN(CCC1)[C@H]1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O.Cl
Biological Activity: Aramisulpride hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride hydrochloride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride hydrochloride can be used in psychiatric research[1][2].
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Aramisulpride hydrochloride | Aramisulpride hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride hydrochloride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride hydrochloride can be used in psychiatric research. | |||||||||||||||||||||
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References
- [1]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7. ACS Omega. 2019 Aug 15;4(9):14151-14154. [Content Brief]
- [2]. Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110(3):808-815. [Content Brief]
Keywords
