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35

Inhibitors & Agonists

1

Screening Libraries

2

Fluorescent Dyes

1

Biochemical Assay Reagents

2

Peptides

1

Inhibitory Antibodies

6

Natural
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1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128945
    CL2A

    		ADC Linker Inflammation/Immunology Cancer
    CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
    CL2A
  • HY-N2995
    Poricoic acid A
    1 Publications Verification

    Poricoic acid A(F)

    		 NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .
    Poricoic acid A
  • HY-101890
    Dabsyl chloride
    2 Publications Verification

    DABS-Cl

    		 Fluorescent Dye Others
    Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.
    Dabsyl chloride
  • HY-N11200
    3-Hydroxyisovalerylcarnitine

    		Endogenous Metabolite Metabolic Disease
    3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise .
    3-Hydroxyisovalerylcarnitine
  • HY-76025S
    1,4-Dibromobenzene-d4

    p-Dibromobenzene-d4

    		 Isotope-Labeled Compounds Inflammation/Immunology
    1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans .
    1,4-Dibromobenzene-d4
  • HY-N0930B
    Galegine hydrochloride

    		AMPK Bacterial Infection Metabolic Disease
    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .
    Galegine hydrochloride
  • HY-112729
    HC-056456
    2 Publications Verification

    3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

    		 Calcium Channel Others
    HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na +]i rise is slowed by HC-056456 (IC50~3 µM).
    HC-056456
  • HY-P99344
    Bamlanivimab

    Anti-Human SARS-CoV-2

    		 SARS-CoV Infection
    Bamlanivimab (Anti-Human SARS-CoV-2) is the first COVID-19 monoclonal antibody (mAb) to be granted Emergency Use Authorization (EUA) in November 2020 by the U.S. Food and agent Administration (FDA). However, Bamlanivimab is withdrawn in April 2021 following the rise of SARS-CoV-2 virus variants resistant to Bamlanivimab .
    Bamlanivimab
  • HY-N0742
    Absinthin

    		Others Others
    Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca 2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .
    Absinthin
  • HY-136500
    Prostaglandin H2

    PGH2

    		 Endogenous Metabolite Amyloid-β Neurological Disease Inflammation/Immunology
    Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease .
    Prostaglandin H2
  • HY-P1079
    ω-Agatoxin TK

    		Calcium Channel Neurological Disease
    ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca 2+ channel blocker. ω-Agatoxin TK inhibits the high K + depolarisation-induced rise in internal Ca 2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .
    ω-Agatoxin TK
  • HY-P1387
    β-Amyloid (1-40) (rat)

    		Amyloid-β Apoptosis Neurological Disease
    β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca 2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease .
    β-Amyloid (1-40) (rat)
  • HY-142998
    Vaxfectin

    		Liposome Interleukin Related IFNAR Infection Inflammation/Immunology
    Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation .
    Vaxfectin
  • HY-B1873
    Methoxychlor

    		Apoptosis Infection
    Methoxychlor is an organochlorine pesticide agent. Methoxychlor induces Ca 2 rise and apoptosis in HA59T cells .
    Methoxychlor
  • HY-W838171
    Tiaramide

    		Calcium Channel Inflammation/Immunology
    Tiaramide is an anti-inflammatory agent. Tiaramide inhibits the PGE2 release. Tiaramide inhibits the rise in intracellular free Ca 2+ induced by PGE2 (HY-101952) as well as Bradykinin (HY-P0206). Tiaramide inhibites Bradykinin-induced contraction .
    Tiaramide
  • HY-128945A
    CL2A TFA

    		ADC Linker Inflammation/Immunology Cancer
    CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
    CL2A TFA
  • HY-160998
    YM-344031

    		CCR Inflammation/Immunology
    YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca [2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model .
    YM-344031
  • HY-W112090
    Palladium meso-tetra(pentafluorophenyl)porphyrin

    PdTFPP; 5,10,15,20-Tetrakis(pentafluorophenyl)-21H,23H-porphine palladium(II)

    		 Fluorescent Dye Others
    Palladium meso-tetra(pentafluorophenyl)porphyrin (PdTFPP) derives from palladium(II), acting as a fluorescence-quenched optical probe and high-performance oxygen concentration sensor with outstanding photostability and antioxidant capacity. Palladium meso-tetra(pentafluorophenyl)porphyrin exhibits reduced luminescence intensity as dissolved oxygen concentration rises. Palladium meso-tetra(pentafluorophenyl)porphyrin can be applied for real-time monitoring of live-cell respiration, hypoxic tissue imaging, and nanofibrous organic semiconductors in photodetectors for ambient oxygen detection .
    Palladium meso-tetra(pentafluorophenyl)porphyrin
  • HY-121005
    Bufetolol

    		Adrenergic Receptor Cardiovascular Disease
    Bufetolol is an inhibitor for β-adrenergic receptor, that affects the maximum velocity of rise of the action potential, and exhibits antiarrhythmic efficacy .
    Bufetolol
  • HY-121776
    Nicomol

    		Drug Derivative Cardiovascular Disease
    Nicomol is an orally active hypolipidemic agent that can increase the high density lipoprotein cholesterol (HDL-C) level. Nicomol inhibits the rapid rise of plasma free fatty acids .
    Nicomol
  • HY-162375
    AF299

    		Drug Intermediate Cardiovascular Disease
    AF299 can reduce collagen-related peptide-induced platelet Ca 2+ rises and collagen-induced platelet aggregation. AF299 can be used for research of antiplatelet research .
    AF299
  • HY-113841
    RS-87337

    		Others Cardiovascular Disease
    RS-87337 is an orally active antiarrhythmic agent that increases the duration and the maximum rate of rise of cardiac muscle action potentials. RS-87337 is promising for research of antiarrhythmic and cardioprotective agents .
    RS-87337
  • HY-175408
    Hepoxilin A3 methyl ester

    HxA3 methyl ester​

    		 Calcium Channel Neurological Disease
    Hepoxilin A3 methyl ester is the ester form of HxA3. Hepoxilin A3 methyl ester causes a receptor-induced rise in intracellular calcium through the release from intracellular stores in suspended human neutrophils .
    Hepoxilin A3 methyl ester
  • HY-131019
    JF-NP-26

    		mGluR Neurological Disease
    JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .
    JF-NP-26
  • HY-113723
    MRS2298

    		P2Y Receptor Cardiovascular Disease
    MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca 2+ rise in platelets with an IC50 of 810 nM .
    MRS2298
  • HY-121776R
    Nicomol (Standard)

    		Drug Derivative Reference Standards Cardiovascular Disease
    Nicomol (Standard) is the analytical standard of Nicomol. This product is intended for research and analytical applications. Nicomol is an orally active hypolipidemic agent that can increase the high density lipoprotein cholesterol (HDL-C) level. Nicomol inhibits the rapid rise of plasma free fatty acids .
    Nicomol (Standard)
  • HY-157546
    VEGFR-2-IN-40

    		VEGFR Interleukin Related Caspase Inflammation/Immunology Cancer
    VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α and IL-6 while showing a four-fold rise in an apoptotic marker caspase-3 .
    VEGFR-2-IN-40
  • HY-132275
    Long trebler phosphoramidite

    		Biochemical Assay Reagents Others
    After the Long trebler phosphoramidite is condensed by the triple condensate, three DNA branches begin to grow simultaneously with each step of the synthesis. Deblock of this construct gives rise to DNA containing a branching point. One arm (stem) is attached to the branch point with its 5'-end, and other arms (branches) are attached with their 3'-ends. Reverse amidites can be used to prepare constructs with different branch orientations.
    Long trebler phosphoramidite
  • HY-12153
    JNJ-1930942

    		Cholinesterase (ChE) Neurological Disease
    JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca 2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice .
    JNJ-1930942
  • HY-N11200R
    3-Hydroxyisovalerylcarnitine (Standard)

    		Endogenous Metabolite Reference Standards Metabolic Disease
    3-Hydroxyisovalerylcarnitine (Standard) is the analytical standard of 3-Hydroxyisovalerylcarnitine. This product is intended for research and analytical applications. 3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise .
    3-Hydroxyisovalerylcarnitine (Standard)
  • HY-N0742R
    Absinthin (Standard)

    		Reference Standards Others Others
    Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .
    Absinthin (Standard)
  • HY-106501A
    Asocainol hydrochloride

    Goe 4704 hydrochloride

    		 Potassium Channel Cardiovascular Disease
    Asocainol hydrochloride (Goe 4704 hydrochloride) is an antiarrhythmic agent. Asocainol hydrochloride reduces the maximum rate of action potential rise and action potential amplitude. Asocainol hydrochloride is applicable for the research of arrhythmias .
    Asocainol hydrochloride
  • HY-101890R
    Dabsyl chloride (Standard)

    DABS-Cl (Standard)

    		 Fluorescent Dye Reference Standards Others
    Dabsyl chloride (Standard) is the analytical standard of Dabsyl chloride (HY-101890). This product is intended for research and analytical applications. Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.
    Dabsyl chloride (Standard)
  • HY-136995
    AFD-21 maleate

    		Sodium Channel Cardiovascular Disease
    AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased .
    AFD-21 maleate
  • HY-175083
    PtdIns-(4,5)-P2-biotin trisodium

    		Drug Derivative PI3K Others
    PtdIns-(4,5)-P2-biotin trisodium is a Biotin-labeled PtdIns-(4,5)-P2 analog. PtdIns-(4,5)-P2-biotin trisodium is an affinity probe of PI3Kγ. PI3Kγ can catalyse the phosphorylation of PtdIns-(4,5)-P2 at the 3′-OH group, giving rise to the second messenger PtdIns(3,4,5)-P3 .
    PtdIns-(4,5)-P2-biotin trisodium

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