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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
sterols compound
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "sterols compound" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside
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Cat. No.: HY-N1200
CAS No.: 19716-26-8
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Synonyms: BAY-W-6341
Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
Cat. No.: HY-W740611
CAS No.: 547-96-6
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16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .
Synonyms: Eleutheroside A (Standard); β-Sitosterol β-D-glucoside (Standard)
Cat. No.: HY-160804
CAS No.: 2419904-59-7
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Desmethyl nevanimibe (Compound 5) is the demethyl precursor of the sterol O-acyltransferase 1 (SOAT1) inhibitor Nevanimibe (PD-132301) .
Cat. No.: HY-158728
CAS No.: 1025068-94-3
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28-Deoxybetulin methyleneamine (compound 36) is a derivative of Betulin. Betulin (HY-N0083) is a sterol regulatory element-binding protein (SREBP) inhibitor .
Cat. No.: HY-D2336
CAS No.: 3038774-43-2
Cat. No.: HY-163631
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Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL .
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Cat. No.: HY-W422288
CAS No.: 79156-75-5
Synonyms: (Rac)-Ketoconazol; (Rac)-R 41400
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(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .
Cat. No.: HY-176210
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CYP51-IN-24 (Compound 22) is a Sterol 14α-Demethylase (CYP51) inhibitor. CYP51-IN-24 exhibits potent inhibitory activity against wild-type and drug-resistant fungi. CYP51-IN-24 inhibits ergosterol biosynthesis by binding to the fungal CYP51 enzyme. CYP51-IN-24 can be used in research and drug development against drug-resistant fungal infections .
Cat. No.: HY-118843
CAS No.: 60628-98-0
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Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .
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Cat. No.: HY-N19063
Cat. No.: HY-N19066
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
