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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
tips
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "tips" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: Tip60 HAT inhibitor
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease .
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6 Cited Publications
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NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells .
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3 Cited Publications
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TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity .
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3 Cited Publications
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TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity .
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1 Cited Publications
Art. -Nr.: HY-P1852
CAS. Nr.: 277302-47-3
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Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
Art. -Nr.: HY-103702
CAS. Nr.: 1807337-58-1
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TIP48/49-IN-1 is an orally active, specific RUVBL1/2 (TIP48/49) ATPase inhibitor with an IC50 of 59 nM against purified RUVBL1/2. TIP48/49-IN-1 inhibits the DNA replication process, leading to S-phase arrest. TIP48/49-IN-1 induces apoptosis. TIP48/49-IN-1 can be used for the research of non-small cell lung cancer (NSCLC) cells .
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Ypenyl is a cytostatic. Ypenyl hydrochloride, belonging to the alkylating agent class, exhibits clear genotoxicity and cell cycle disruption properties. Ypenyl induces chromosomal aberrations in broad bean root tip meristem cells and leads to a decrease in the mitotic index. Ypenyl may be used in cancer research .
Art. -Nr.: HY-W751066
CAS. Nr.: 2734498-74-7
Art. -Nr.: HY-W560961
CAS. Nr.: 828247-65-0
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3',5'-TIPS-N-Ac-Adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
Art. -Nr.: HY-W747112
CAS. Nr.: 68279-24-3
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Art. -Nr.: HY-W721582
CAS. Nr.: 499-23-0
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Art. -Nr.: HY-121801
CAS. Nr.: 84527-51-5
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Zarilamid is a fungicide which is active against a broad spectrum of Oomycete fungi. Zarilamid inhibits nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide inhibits growth of tobacco roots and causes swelling of the root tips, destructs microtubule cytoskeleton and inhibits mitosis .
Art. -Nr.: HY-119609
CAS. Nr.: 22562-67-0
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Art. -Nr.: HY-W129617
CAS. Nr.: 85335-73-5
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3',5'-TIPS-N-Ac-Cytidine is a monomeric raw material that can be used for nucleic acid synthesis.
Art. -Nr.: HY-178651
CAS. Nr.: 1472616-97-9
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DNA 5-Ethynyl(TIPS)-U amidite is a monomeric raw material that can be used for nucleic acid synthesis.
Art. -Nr.: HY-W075470
CAS. Nr.: 373596-08-8
Synonyms: tips Pentacene
6,13-Bis((triisopropylsilyl)ethynyl)pentacene (TIPS Pentacene) is a metal-organic framework (MOF).
Art. -Nr.: HY-W128600
CAS. Nr.: 69304-38-7
Synonyms: 3',5'-tips-Uridine
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3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine (3',5'-TIPS-Uridine) is a monomeric raw material that can be used for nucleic acid synthesis.
Art. -Nr.: HY-W721611
CAS. Nr.: 1918-11-2
Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
