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tissue-type plasminogen activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PAI-1 (2) Amyloid-β (1) Apoptosis (1) Autophagy (1) COX (1) ERK (1) Factor Xa (1) JNK (1) MMP (1) Proteasome (1) Ser/Thr Protease (3) Thrombin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Inflammation/Immunology (1) Neurological Disease (2)

Inhibitors & Agonists

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Recombinant Proteins

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Targets Recommended: Plasminogen/Plasmin PAI-1

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-111056

UK122 TFA 1 Publications Verification	Ser/Thr Protease	Cancer
UK122 is a potent and selective *urokinase-type plasminogen* activator (uPA) inhibitor with an IC₅₀** of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-14759

Aleplasinin PAZ-417	PAI-1 Amyloid-β	Neurological Disease
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC₅₀=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Thrombin COX ERK JNK Factor Xa	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-114150

D-Val-Leu-Arg-pNA	PAI-1	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

HY-P11413

PAI-1	Ser/Thr Protease	Cardiovascular Disease
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .

HY-111056A

UK122 hydrochloride 1 Publications Verification	Ser/Thr Protease	Cancer
UK122 hydrochloride is a potent and selective *urokinase-type plasminogen* activator (uPA) inhibitor with an IC₅₀** of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-123255

BSc2118	Proteasome MMP Apoptosis Autophagy	Cardiovascular Disease Neurological Disease Cancer
BSc2118 is a 20S proteasome inhibitor with an IC₅₀ of approximately 50 nM. BSc2118 induces G₂/M phase cell cycle arrest and apoptosis in myeloma cells, inhibits cytoprotective autophagy, and suppresses tumor angiogenesis. BSc2118 reduces MMP9 activity, promotes angioneurogenesis, and alleviates recombinant tissue-type plasminogen activator-induced cerebral toxicity. BSc2118 is applicable to studies related to cerebral ischemia and multiple myeloma .

Cat. No.	상품명	Target	Research Area

HY-114150

D-Val-Leu-Arg-pNA	PAI-1	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

HY-P11413

PAI-1	Ser/Thr Protease	Cardiovascular Disease
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields Source Classification	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

Species:	Human (1) Mouse (2)
Tag:	His (1) Tag Free (1) Fc (1)
Source:	HEK293 (3)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P73583

	T-PA Protein, Mouse (HEK293, Fc) tissue-type plasminogen activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond.This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration.T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction.T-PA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P701312

	T-PA Protein, Mouse (HEK293, His) tissue-type plasminogen activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond.This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration.T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction.T-PA Protein, Mouse (HEK293, His) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with C-His labeled tag.

HY-P73451

	T-PA Protein, Human (HEK293) T-PA; TPA; t-plasminogen activator; tissue plasminogen activator	Human	HEK293
	The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin, a key enzyme involved in tissue remodeling and cell migration. The proteolytic process produces heavy and light chains, forming heterodimeric enzymes. T-PA Protein, Human (HEK293) is the recombinant human-derived T-PA protein, expressed by HEK293 , with tag free.

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HY-P83461

	Tissue Type Plasminogen Activator Antibody (YA3206) TPA; T-PA; TPA1; PLAT; tissue plasminogen activator	WB, IHC-P	Human, Mouse, Rat
	Tissue Type Plasminogen Activator Antibody (YA3206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tissue Type Plasminogen Activator.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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