Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
tissue-type plasminogen activator
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "tissue-type plasminogen activator" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-P71051
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; plasminogen activator, tissue type; TPA; tissue-type plasminogen activator; plasminogen activator, tissue; T-plasminogen activator; plasminogen/activator Kringle; Alteplase; plasminogen activator; Reteplase
3
3 Cited Publications
Target:
Research Areas:
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
3
3 Cited Publications
Cat. No.: HY-111056A
Target:
Research Areas:
UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
1
Synonyms: PAZ-417
Research Areas:
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease .
Cat. No.: HY-165084
CAS No.: 383908-63-2
Synonyms: Soy PS sodium
Research Areas:
L-α-Phosphatidylserine sodium (Soy PS sodium) is a negatively charged phospholipid that acts as an allosteric activator to activate latent plasminogen activator inhibitor-1 (PAI-1). L-α-Phosphatidylserine does not directly alter the catalytic activity of t-PA, but regulates fibrinolytic activity solely by inducing conformational remodeling of PAI-1. L-α-Phosphatidylserine sodium is an antigen targeting phosphatidylserine (PS) and can induce the production of polyclonal antibodies. L-α-Phosphatidylserine is mainly used in studies related to immunology, fibrinolytic system and coagulation homeostasis .
Cat. No.: HY-114150
CAS No.: 64816-14-4
Cat. No.: HY-P73451
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; plasminogen activator, tissue type; TPA; tissue-type plasminogen activator; plasminogen activator, tissue; T-plasminogen activator; plasminogen/activator Kringle; Alteplase; plasminogen activator; Reteplase
Cat. No.: HY-P73583
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; plasminogen activator, tissue type; TPA; tissue-type plasminogen activator; plasminogen activator, tissue; T-plasminogen activator; plasminogen/activator Kringle; Alteplase; plasminogen activator; Reteplase
Cat. No.: HY-P701312
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PLAT; T-PA; plasminogen activator, tissue type; TPA; tissue-type plasminogen activator; plasminogen activator, tissue; T-plasminogen activator; plasminogen/activator Kringle; Alteplase; plasminogen activator; Reteplase
Cat. No.: HY-123255
CAS No.: 863924-64-5
Target:
Research Areas:
BSc2118 is a 20S proteasome inhibitor with an IC50 of approximately 50 nM. BSc2118 induces G2/M phase cell cycle arrest and apoptosis in myeloma cells, inhibits cytoprotective autophagy, and suppresses tumor angiogenesis. BSc2118 reduces MMP9 activity, promotes angioneurogenesis, and alleviates recombinant tissue-type plasminogen activator-induced cerebral toxicity. BSc2118 is applicable to studies related to cerebral ischemia and multiple myeloma .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
