2. Metabolic Enzyme/Protease Neuronal Signaling
  3. PAI-1 Amyloid-β
  4. Aleplasinin

Aleplasinin  (Synonyms: PAZ-417)

Cat. No.: HY-14759 Purity: 99.26%
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Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

Aleplasinin Chemical Structure

Aleplasinin Chemical Structure

CAS No. : 481629-87-2

Size Price Stock Quantity
5 mg USD 380 In-stock
10 mg USD 620 In-stock
25 mg USD 1250 In-stock
50 mg USD 2000 In-stock
100 mg USD 3200 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].

Clinical Trial
Molecular Weight

425.52

Formula

C28H27NO3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)C(C1=CN(CC2=CC=C(C(C)(C)C)C=C2)C3=C1C=C(C4=CC=CC(C)=C4)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (587.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3501 mL 11.7503 mL 23.5007 mL
5 mM 0.4700 mL 2.3501 mL 4.7001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3501 mL 11.7503 mL 23.5007 mL 58.7516 mL
5 mM 0.4700 mL 2.3501 mL 4.7001 mL 11.7503 mL
10 mM 0.2350 mL 1.1750 mL 2.3501 mL 5.8752 mL
15 mM 0.1567 mL 0.7834 mL 1.5667 mL 3.9168 mL
20 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9376 mL
25 mM 0.0940 mL 0.4700 mL 0.9400 mL 2.3501 mL
30 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9584 mL
40 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
50 mM 0.0470 mL 0.2350 mL 0.4700 mL 1.1750 mL
60 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9792 mL
80 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
100 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5875 mL
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Aleplasinin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aleplasinin481629-87-2PAZ-417PAZ417PAZ 417PAI-1Amyloid-βPlasminogen activator inhibitor-1β-amyloid peptideAβAbetaamyloid-βAlzheimer's diseaseorally activeBBB-penetratedmemory deficiencySerpin familyInhibitorinhibitorinhibit

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