863924-64-5
Chemical Structure
BSc2118
- CAS No.: 863924-64-5
- Formula:C28H43N3O7
- Molecular Weight:533.66
IUPAC Name: tert-butyl (S)-3-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-4-(((S)-4-methyl-1-oxopentan-2-yl)amino)-4-oxobutanoate
InChIKey: IWBUYMFIYWDGMJ-VABKMULXSA-N
SMILES: CC(C[C@H](NC(OCC1=CC=CC=C1)=O)C(N[C@@H](CC(OC(C)(C)C)=O)C(N[C@@H](CC(C)C)C=O)=O)=O)C
Biological Activity: BSc2118 is a 20S proteasome inhibitor with an IC50 of approximately 50 nM. BSc2118 induces G2/M phase cell cycle arrest and apoptosis in myeloma cells, inhibits cytoprotective autophagy, and suppresses tumor angiogenesis. BSc2118 reduces MMP9 activity, promotes angioneurogenesis, and alleviates recombinant tissue-type plasminogen activator-induced cerebral toxicity. BSc2118 is applicable to studies related to cerebral ischemia and multiple myeloma[1][2].
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BSc2118 | BSc2118 is a 20S proteasome inhibitor with an IC50 of approximately 50 nM. BSc2118 induces G2/M phase cell cycle arrest and apoptosis in myeloma cells, inhibits cytoprotective autophagy, and suppresses tumor angiogenesis. BSc2118 reduces MMP9 activity, promotes angioneurogenesis, and alleviates recombinant tissue-type plasminogen activator-induced cerebral toxicity. BSc2118 is applicable to studies related to cerebral ischemia and multiple myeloma. | |||||||||||||||||||||
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- [1]. Doeppner TR, et al. The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis. Brain. 2012;135(Pt 11):3282-3297. [Content Brief]
- [2]. Zang M, et al. Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma. Cancer Lett. 2015;366(2):173-181. [Content Brief]
Keywords
