2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease GPCR/G Protein
  3. STING Reactive Oxygen Species (ROS) CXCR Interleukin Related
  4. STING-IN-18

STING-IN-18 is an orally active STING inhibitor. STING-IN-18 exhibits an IC50 of 86 nM against STING in murine RAW-LuciaTM ISG cells. STING-IN-18 inhibits STING activation and blocks downstream signaling pathways. STING-IN-18 suppresses kidney injury and inflammation. STING-IN-18 can be used for the research of autoimmune and inflammatory diseases.

For research use only. We do not sell to patients.

STING-IN-18

STING-IN-18 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

STING-IN-18 Related Antibodies

Top Publications Citing Use of Products

View All CXCR Isoform Specific Products:

View All Isoforms
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

STING-IN-18 is an orally active STING inhibitor. STING-IN-18 exhibits an IC50 of 86 nM against STING in murine RAW-LuciaTM ISG cells. STING-IN-18 inhibits STING activation and blocks downstream signaling pathways. STING-IN-18 suppresses kidney injury and inflammation. STING-IN-18 can be used for the research of autoimmune and inflammatory diseases[1].

In Vitro

STING-IN-18 (Compound QQ21) (1-5 μM; 14 h) inhibits the downstream signaling pathway of STING in RAW264.7 and THP-1 cells, and reduces the levels of IFNβ, TNFα, IL6 and CXCL10[1].
STING-IN-18 (2.5-5 μM; 24 h) reduces Cisplatin (HY-17394)-induced ROS production in THP-1 cells in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING-IN-18 Related Antibodies

Real Time qPCR[1]

Cell Line: RAW264.7 and THP-1
Concentration: 1 and 5 μM
Incubation Time: Pretreated for 2 h, and treated with MSA-2 (HY-136927) for 14 h.
Result: Inhibited the mRNA levels of FNβ, TNFα, IL6, and CXCL10 in a dose-dependent manner.
In Vivo

STING-IN-18 (5 mg/kg i.p.; 10 mg/kg p.o.; single dose) effectively inhibits the activation of the STING pathway in mice[1].
STING-IN-18 (10 mg/kg; i.p.; 4 days) effectively alleviates Cisplatin (HY-17394)-induced acute kidney injury in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (male, 8 weeks old, acute kidney injury model induced by Cisplatin (HY-17394) )[1]
Dosage: 10 mg/kg
Administration: i.p.; daily; 4 days
Result: Alleviated kidney enlargement and ischemic symptoms. Reduced elevated blood urea nitrogen (BUN) and serum creatinine levels.
Inhibited cisplatin-induced upregulation of IFNβ and TNFα protein levels.
Mitigated renal injury observed via H&E staining.
Molecular Weight

339.37

Formula

C18H18FN5O
SMILES

FC1=CC=C2C(C(NC(C3=NC=C(NC4CCCC4)N=C3)=O)=CN2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

STING-IN-18 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-18STINGReactive Oxygen Species (ROS)CXCRInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSCXC chemokine receptorsC-X-C motif chemokine receptorsILacute kidney injuryIL6TNFαTHP-1 cellsRAW-Lucia? ISG cellsRAW264.7 cellscisplatinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
STING-IN-18
Cat. No.:
HY-181057
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.